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851.
Multiple dopamine D4 receptor variants in the human population. 总被引:32,自引:0,他引:32
H H Van Tol C M Wu H C Guan K Ohara J R Bunzow O Civelli J Kennedy P Seeman H B Niznik V Jovanovic 《Nature》1992,358(6382):149-152
The dopamine D4 receptor structurally and pharmacologically resembles the dopamine D2 and D3 receptors. Clozapine, an atypical antipsychotic that is relatively free of the adverse effects of drug-induced parkinsonism and tardive dyskinesia, binds to the D4 receptor with an affinity 10 times higher than to the D2 and D3 receptors. This may explain clozapine's atypical properties. Here we report the existence of at least three polymorphic variations in the coding sequence of the human D4 receptor. A 48-base-pair sequence in the putative third cytoplasmic loop of this receptor exists either as a direct-repeat sequence (D4.2), as a fourfold repeat (D4.4) or as a sevenfold repeat (D4.7). Two more variant alleles were detected in humans. Expression of the complementary DNA for the three cloned receptor variants showed different properties for the long form (D4.7) and the shorter forms (D4.2, D4.4) with respect to clozapine and spiperone binding. To our knowledge, this is the first report of a receptor in the catecholamine receptor family that displays polymorphic variation in the human population. Such variation among humans may underlie individual differences in susceptibility to neuropsychiatric disease and in responsiveness to antipsychotic medication. 相似文献
852.
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. 总被引:15,自引:0,他引:15
The antidiuretic effect of arginine vasopressin (AVP) is mediated by renal-type (V2) receptors linked to adenylyl cyclase. We report here the cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, and with similarity to the V1a (hepatic) AVP receptor in its seven membrane-spanning domains. Expression of the cloned cDNA in mammalian cells showed specific ligand binding and activity characteristic of the native V2 AVP receptor. The receptor messenger RNA is detected only in the kidney. The human V2 receptor gene has been localized to the long arm of the X chromosome close to the locus for nephrogenic diabetes insipidus, an X-linked recessive disorder characterized by renal resistance to the antidiuretic action of AVP. 相似文献
853.
Chai Benliang China Defense Science & Technology Information Center P.O. Box Beijing China 《系统工程与电子技术(英文版)》1992,(3)
The author uses system analysis to provide system thinkings of the deepening reform of the management of defence science, technology and industry (DSTI) and investigate the system definition of DSTI, the system reform target, system operational mechanism, institutional structure, coordination and control functions and the orientation of conversion in China. 相似文献
854.
Liu DeguiBeijing Institute of Computer Application Simulation Technology. P. O. Box Beijing . China 《系统工程与电子技术(英文版)》1993,(4)
In this paper two classes of equivalence transform methods for solving ordinary differential equations are proposed. One class of method is the equivalence integral transform method for special differential algebraic problems. The advantage of this class of method is such that the amount of work calculating one integration with parameters becomes that of two interpolations, when the system of nonlinear equations is solved on the right hand side function. The other class of method is the equivalence substitution method tor avoiding calculating derivative on the right hand side function. In order to avoid calculation derivatives, two equivalence substitution methods are proposed here. The application instances of some special effect of the equivalence substitution methods are given. 相似文献
855.
1,2,4-Triazolidine-3,5-diones and the 3,5-isoxazolidinedione were observed to be potent inhibitors of rat lens aldose reductase activity. In vivo in streptozotocin-diabetic rats, selected agents at 20 mg/kg/day, orally for 21 days reduced significantly the sorbitol levels of rbc, lens and sciatic nerves, suggesting that these derivatives may have some usefulness to treat clinical complications of diabetes mellitus. 相似文献
856.
O. Hoffmann-Ostenhof H. Moser E. Putz 《Cellular and molecular life sciences : CMLS》1948,4(9):352-352
Summary The authors describe a monophosphoesterase isolated from yeast which acts strongly on sodium phenolphthaleinphosphate, phenolphosphate, and-glycerophosphate in an alkaline medium (p
H 8,5–9,1). The enzyme does not need magnesium ions for its activity. 相似文献
857.
Identification of a widespread nuclear actin binding protein 总被引:16,自引:0,他引:16
858.
An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes 总被引:26,自引:0,他引:26
Insulin-dependent diabetes mellitus is widely believed to be an autoimmune disease. Recent onset diabetics show destruction of insulin-secreting pancreatic beta-cells associated with a lymphocytic infiltrate (insulitis), with autoantibodies to beta-cells being found even before the onset of symptoms. Susceptibility to the disease is strongly influenced by major histocompatibility complex (MHC) class II polymorphism in both man and experimental animal models such as the non-obese diabetic (NOD) mouse. As MHC class II molecules are usually associated with dominant immune responsiveness, it was surprising that introduction of a transgenic class II molecule, I-E, protected NOD mice from insulitis and diabetes. This could be explained by a change either in the target tissue or in the T cells presumed to be involved in beta-cell destruction. Recently, several studies have shown that I-E molecules are associated with ontogenetic deletion of T cells bearing antigen/MHC receptors encoded in part by certain T-cell receptor V beta gene segments. To determine the mechanism of the protective effect of I-E, we have produced cloned CD4+ and CD8+ T-cell lines from islets of recently diabetic NOD mice. These cloned lines are islet-specific and pathogenic in both I-E- and I-E+ mice. Both CD4+ and CD8+ cloned T cells bear receptors encoded by a V beta 5 gene segment, known to be deleted during development in I-E expressing mice. Our data provide, therefore, an explanation for the puzzling effect of I-E on susceptibility to diabetes in NOD mice. 相似文献
859.
860.
Androgenic control of a sex-dependent protein in the rat 总被引:7,自引:0,他引:7