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81.
Plzf is required in adult male germ cells for stem cell self-renewal 总被引:21,自引:0,他引:21
Buaas FW Kirsh AL Sharma M McLean DJ Morris JL Griswold MD de Rooij DG Braun RE 《Nature genetics》2004,36(6):647-652
82.
83.
J P Braun S Sener A Rico P Benard V Burgat-Sacaze 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(11):959-962
Daily intraperitoneal injection of 2.5 or 5 mumole HgCl2 to male Rats weighing 250 to 350 g induces an early intense increase of urine gamma-glutamyl transferase activity. In the same conditions, equimolecular administration of sodium selenite and mercuric chloride induces no increase of the enzymuria for the low dose: for the high dose- a minor and more persistent increase of urine GGT is observed. Thus, the activity of urines GGT allows, in vivo, to establish that sodium selenite protects Rat kidney against toxic effects of mercuric chloride. 相似文献
84.
In gap junctions, identical membrane proteins are linked up in pairs (dyads) that bridge the extracellular space between two apposed cell membranes. Typically, several thousand of these dyads are aggregated in the plane of the membranes and form a junctional plaque with a distinct boundary. The question thus arises as to what maintains the dyads in an aggregated state. From a statistical mechanical analysis of the positions of dyads in a freeze-fracture electron micrograph, we report here that the aggregates are not maintained by an attractive force between pairs of dyads, but probably by the minimization of the repulsive force between apposed membranes. On the basis of this analysis we present a model for the structure of mature gap junctions as well as certain aspects of the formation and disassembly of gap junctions. 相似文献
85.
86.
U. Braun Gisela Braun Th. Sargent III 《Cellular and molecular life sciences : CMLS》1980,36(2):207-209
Summary A new technique is described for measurement of diffusion across the blood-brain barrier using intraventricularly administered68Ga-EDTA, and determining loss from the brain with a scintillation camera. Repeated injections via permanent cannulas showed that the diffusion half-time was reduced to 50% of control values after intraventricular d-amphetamine and 6-hydroxydopamine; pimozide had no effect.Acknowledgment. This work was supported by the Division of Biomedical and Environmental Research of the US Department of Energy, and the Deutsche Forschungsgemeinschaft. 相似文献
87.
Summary The absorption of3H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0×10–2
M), ethacrynic acid (0.5×10–3
M), and mersalyl (8.0×10–3
M) indicating that digitoxin absorption is at least partly an active process. 相似文献
88.
M. Huber-Lukaĉ H. Herbst P. Lüthy D. G. Braun 《Cellular and molecular life sciences : CMLS》1982,38(9):1103-1105
Summary Monoclonal antibodies against the toxic units ofBacillus thuringiensis delta-endotoxin were raised by the hybridoma technique and detected by an indirect enzyme-linked immunosorbent assay (ELISA). Out of 5 positive clones, I was found to secrete antibodies which inactivate the toxin. 相似文献
89.
Hinke CB Böhmer M Boutachkov P Faestermann T Geissel H Gerl J Gernhäuser R Górska M Gottardo A Grawe H Grębosz JL Krücken R Kurz N Liu Z Maier L Nowacki F Pietri S Podolyák Z Sieja K Steiger K Straub K Weick H Wollersheim HJ Woods PJ Al-Dahan N Alkhomashi N Ataç A Blazhev A Braun NF Čeliković IT Davinson T Dillmann I Domingo-Pardo C Doornenbal PC de France G Farrelly GF Farinon F Goel N Habermann TC Hoischen R Janik R Karny M Kaşkaş A Kojouharov IM Kröll T Litvinov Y Myalski S Nebel F 《Nature》2012,486(7403):341-345
The shell structure of atomic nuclei is associated with 'magic numbers' and originates in the nearly independent motion of neutrons and protons in a mean potential generated by all nucleons. During β(+)-decay, a proton transforms into a neutron in a previously not fully occupied orbital, emitting a positron-neutrino pair with either parallel or antiparallel spins, in a Gamow-Teller or Fermi transition, respectively. The transition probability, or strength, of a Gamow-Teller transition depends sensitively on the underlying shell structure and is usually distributed among many states in the neighbouring nucleus. Here we report measurements of the half-life and decay energy for the decay of (100)Sn, the heaviest doubly magic nucleus with equal numbers of protons and neutrons. In the β-decay of (100)Sn, a large fraction of the strength is observable because of the large decay energy. We determine the largest Gamow-Teller strength so far measured in allowed nuclear β-decay, establishing the 'superallowed' nature of this Gamow-Teller transition. The large strength and the low-energy states in the daughter nucleus, (100)In, are well reproduced by modern, large-scale shell model calculations. 相似文献
90.
Jonas Protze Doreen Braun Katrin Manuela Hinz Dorothea Bayer-Kusch Ulrich Schweizer Gerd Krause 《Cellular and molecular life sciences : CMLS》2017,74(12):2299-2318
Monocarboxylate transporter 8 (MCT8) mediates thyroid hormone (TH) transport across the plasma membrane in many cell types. In order to better understand its mechanism, we have generated three new MCT8 homology models based on sugar transporters XylE in the intracellular opened (PDB ID: 4aj4) and the extracellular partly occluded (PDB ID: 4gby) conformations as well as FucP (PDB ID: 3o7q) and GLUT3 (PDB ID: 4zwc) in the fully extracellular opened conformation. T3-docking studies from both sides revealed interactions with His192, His415, Arg445 and Asp498 as previously identified. Selected mutations revealed further transport-sensitive positions mainly at the discontinuous transmembrane helices TMH7 and 10. Lys418 is potentially involved in neutralising the charge of the TH substrate because it can be replaced by charged, but not by uncharged, amino acids. The side chain of Thr503 was hypothesised to stabilise a helix break at TMH10 that undergoes a prominent local shift during the transport cycle. A T503V mutation accordingly affected transport. The aromatic Tyr419, the polar Ser313 and Ser314 as well as the charged Glu422 and Glu423 lining the transport channel have been studied. Based on related sugar transporters, we suggest an alternating access mechanism for MCT8 involving a series of amino acid positions previously and newly identified as critical for transport. 相似文献