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排序方式: 共有58条查询结果,搜索用时 15 毫秒
21.
Madhusudhan N Harrington J Stevenson KB Nymeyer S Campo CJ Wheatley PJ Deming D Blecic J Hardy RA Lust NB Anderson DR Collier-Cameron A Britt CB Bowman WC Hebb L Hellier C Maxted PF Pollacco D West RG 《Nature》2011,469(7328):64-67
The carbon-to-oxygen ratio (C/O) in a planet provides critical information about its primordial origins and subsequent evolution. A primordial C/O greater than 0.8 causes a carbide-dominated interior, as opposed to the silicate-dominated composition found on Earth; the atmosphere can also differ from those in the Solar System. The solar C/O is 0.54 (ref. 3). Here we report an analysis of dayside multi-wavelength photometry of the transiting hot-Jupiter WASP-12b (ref. 6) that reveals C/O?≥?1 in its atmosphere. The atmosphere is abundant in CO. It is depleted in water vapour and enhanced in methane, each by more than two orders of magnitude compared to a solar-abundance chemical-equilibrium model at the expected temperatures. We also find that the extremely irradiated atmosphere (T?>?2,500?K) of WASP-12b lacks a prominent thermal inversion (or stratosphere) and has very efficient day-night energy circulation. The absence of a strong thermal inversion is in stark contrast to theoretical predictions for the most highly irradiated hot-Jupiter atmospheres. 相似文献
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Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis 总被引:1,自引:0,他引:1
Ngaki MN Louie GV Philippe RN Manning G Pojer F Bowman ME Li L Larsen E Wurtele ES Noel JP 《Nature》2012,485(7399):530-533
Specialized metabolic enzymes biosynthesize chemicals of ecological importance, often sharing a pedigree with primary metabolic enzymes. However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown. In vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step in the production of plant flavonoids, compounds that contribute to attraction, defence and development. CHI operates near the diffusion limit with stereospecific control. Although associated primarily with plants, the CHI fold occurs in several other eukaryotic lineages and in some bacteria. Here we report crystal structures, ligand-binding properties and in vivo functional characterization of a non-catalytic CHI-fold family from plants. Arabidopsis thaliana contains five actively transcribed genes encoding CHI-fold proteins, three of which additionally encode amino-terminal chloroplast-transit sequences. These three CHI-fold proteins localize to plastids, the site of de novo fatty-acid biosynthesis in plant cells. Furthermore, their expression profiles correlate with those of core fatty-acid biosynthetic enzymes, with maximal expression occurring in seeds and coinciding with increased fatty-acid storage in the developing embryo. In vitro, these proteins are fatty-acid-binding proteins (FAPs). FAP knockout A. thaliana plants show elevated α-linolenic acid levels and marked reproductive defects, including aberrant seed formation. Notably, the FAP discovery defines the adaptive evolution of a stereospecific and catalytically 'perfected' enzyme from a non-enzymatic ancestor over a defined period of plant evolution. 相似文献
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Observations of the 21-centimetre line of atomic hydrogen in the early Universe directly probe the history of the reionization of the gas between galaxies. The observations are challenging, though, because of the low expected signal strength (~10?mK), and contamination by strong (>100?K) foreground synchrotron emission in the Milky Way and extragalactic continuum sources. If reionization happened rapidly, there should be a characteristic signature visible against the smooth foreground in an all-sky spectrum. Here we report an all-sky spectrum between 100 and 200?MHz, corresponding to the redshift range 6?相似文献
27.
Zusammenfassung Injektion von14C-Lysin in 320 bis 750 Tage alten Mäusen deutet darauf hin, dass während des Alterns alte Proteinmoleküle infolge ihrer Strukturänderung rascher katabolisiert werden als neue. 相似文献
28.
H. M. Bowman G. H. Hirsch J. B. Hook 《Cellular and molecular life sciences : CMLS》1973,29(8):955-956
Zusammenfassung Nierenschnitte von verschiedenen Arten akkumulieren PAH mit zunehmendem pH-Wert des Mediums bei einem deutlichen Maximum zwischen pH 7.4 und pH 8.0
Supported in part by USPHS grant No. AM-10913.
USPHS predoctoral trainee (GM-01761).
Predoctoral Fellow of the Canadian Food and Drug Directorate, Ottawa. 相似文献
Supported in part by USPHS grant No. AM-10913.
USPHS predoctoral trainee (GM-01761).
Predoctoral Fellow of the Canadian Food and Drug Directorate, Ottawa. 相似文献
29.
Sliding clamps are ring-shaped proteins that encircle DNA and confer high processivity on DNA polymerases. Here we report the crystal structure of the five-protein clamp loader complex (replication factor-C, RFC) of the yeast Saccharomyces cerevisiae, bound to the sliding clamp (proliferating cell nuclear antigen, PCNA). Tight interfacial coordination of the ATP analogue ATP-gammaS by RFC results in a spiral arrangement of the ATPase domains of the clamp loader above the PCNA ring. Placement of a model for primed DNA within the central hole of PCNA reveals a striking correspondence between the RFC spiral and the grooves of the DNA double helix. This model, in which the clamp loader complex locks onto primed DNA in a screw-cap-like arrangement, provides a simple explanation for the process by which the engagement of primer-template junctions by the RFC:PCNA complex results in ATP hydrolysis and release of the sliding clamp on DNA. 相似文献
30.
North TE Goessling W Walkley CR Lengerke C Kopani KR Lord AM Weber GJ Bowman TV Jang IH Grosser T Fitzgerald GA Daley GQ Orkin SH Zon LI 《Nature》2007,447(7147):1007-1011