全文获取类型
收费全文 | 1077篇 |
免费 | 9篇 |
国内免费 | 2篇 |
专业分类
系统科学 | 43篇 |
丛书文集 | 2篇 |
教育与普及 | 1篇 |
理论与方法论 | 13篇 |
现状及发展 | 559篇 |
研究方法 | 111篇 |
综合类 | 335篇 |
自然研究 | 24篇 |
出版年
2018年 | 13篇 |
2017年 | 13篇 |
2016年 | 18篇 |
2015年 | 15篇 |
2014年 | 12篇 |
2013年 | 21篇 |
2012年 | 58篇 |
2011年 | 74篇 |
2010年 | 30篇 |
2009年 | 7篇 |
2008年 | 51篇 |
2007年 | 43篇 |
2006年 | 51篇 |
2005年 | 41篇 |
2004年 | 38篇 |
2003年 | 39篇 |
2002年 | 35篇 |
2001年 | 15篇 |
2000年 | 19篇 |
1999年 | 24篇 |
1998年 | 12篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1986年 | 10篇 |
1985年 | 5篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 17篇 |
1979年 | 27篇 |
1978年 | 25篇 |
1977年 | 22篇 |
1976年 | 16篇 |
1975年 | 13篇 |
1974年 | 14篇 |
1973年 | 22篇 |
1972年 | 20篇 |
1971年 | 23篇 |
1970年 | 33篇 |
1969年 | 23篇 |
1968年 | 19篇 |
1967年 | 17篇 |
1966年 | 20篇 |
1965年 | 10篇 |
1954年 | 7篇 |
排序方式: 共有1088条查询结果,搜索用时 140 毫秒
81.
82.
83.
84.
85.
In many aquatic ecosystems, most microbes live in matrix-enclosed biofilms and contribute substantially to energy flow and nutrient cycling. Little is known, however, about the coupling of structure and dynamics of these biofilms to ecosystem function. Here we show that microbial biofilms changed the physical and chemical microhabitat and contributed to ecosystem processes in 30-m-long stream mesocosms. Biofilm growth increased hydrodynamic transient storage-streamwater detained in quiescent zones, which is a major physical template for ecological processes in streams-by 300% and the retention of suspended particles by 120%. In addition, by enhancing the relative uptake of organic molecules of lower bioavailability, the interplay of biofilm microarchitecture and mass transfer changed their downstream linkage. As living zones of transient storage, biofilms bring hydrodynamic retention and biochemical processing into close spatial proximity and influence biogeochemical processes and patterns in streams. Thus, biofilms are highly efficient and successful ecological communities that may also contribute to the influence that headwater streams have on rivers, estuaries and even oceans through longitudinal linkages of local biogeochemical and hydrodynamic processes. 相似文献
86.
Comparative genomics: Insecticide resistance in mosquito vectors 总被引:8,自引:0,他引:8
Weill M Lutfalla G Mogensen K Chandre F Berthomieu A Berticat C Pasteur N Philips A Fort P Raymond M 《Nature》2003,423(6936):136-137
87.
Neurulation is a complex process of histogenesis involving the precise temporal and spatial organization of gene expression. Genes influencing neurulation include proneural genes determining primary cell fate, neurogenic genes involved in lateral inhibition pathways and genes controlling the frequency of mitotic events. This is reflected in the aetiology and genetics of human and mouse neural tube defects, which are of both multifactorial and multigenic origin. The X-linked gene Nap1l2, specifically expressed in neurons, encodes a protein that is highly similar to the nucleosome assembly (NAP) and SET proteins. We inactivated Nap1l2 in mice by gene targeting, leading to embryonic lethality from mid-gestation onwards. Surviving mutant chimaeric embryos showed extensive surface ectoderm defects as well as the presence of open neural tubes and exposed brains similar to those observed in human spina bifida and anencephaly. These defects correlated with an overproduction of neuronal precursor cells. Protein expression studies showed that the Nap1l2 protein binds to condensing chromatin during S phase and in apoptotic cells, but remained cytoplasmic during G1 phase. Nap1l2 therefore likely represents a class of tissue-specific factors interacting with chromatin to regulate neuronal cell proliferation. 相似文献
88.
Evidence from Sardinian basalt geochemistry for recycling of plume heads into the Earth's mantle 总被引:1,自引:0,他引:1
Gasperini D Blichert-Toft J Bosch D Del Moro A Macera P Télouk P Albarède F 《Nature》2000,408(6813):701-704
Up to 10 per cent of the ocean floor consists of plateaux--regions of unusually thick oceanic crust thought to be formed by the heads of mantle plumes. Given the ubiquitous presence of recycled oceanic crust in the mantle source of hotspot basalts, it follows that plateau material should also be an important mantle constituent. Here we show that the geochemistry of the Pleistocene basalts from Logudoro, Sardinia, is compatible with the remelting of ancient ocean plateau material that has been recycled into the mantle. The Sr, Nd and Hf isotope compositions of these basalts do not show the signature of pelagic sediments. The basalts' low CaO/Al2O3 and Ce/Pb ratios, their unradiogenic 206Pb and 208Pb, and their Sr, Ba, Eu and Pb excesses indicate that their mantle source contains ancient gabbros formed initially by plagioclase accumulation, typical of plateau material. Also, the high Th/U ratios of the mantle source resemble those of plume magmas. Geochemically, the Logudoro basalts resemble those from Pitcairn Island, which contain the controversial EM-1 component that has been interpreted as arising from a mantle source sprinkled with remains of pelagic sediments. We argue, instead, that the EM-1 source from these two localities is essentially free of sedimentary material, the geochemical characteristics of these lavas being better explained by the presence of recycled oceanic plateaux. The storage of plume heads in the deep mantle through time offers a convenient explanation for the persistence of chemical and mineralogical layering in the mantle. 相似文献
89.
Louis J.Ignarro 《当代地方科技》2007,(4):46-47
一氧化氮是生物学中最简单的分子之一。尽管它的结构及其简单,但目前一氧化氮被认为是体内最重要的信号分子,对机体健康至关重要。一氧化氮是一种很强的信号分子,存在于心血管系统、神经系统乃至全身。在一氧化氮的诸多作用中,以血管舒张作用最为重要。一氧化氮可舒张和扩张血管以确保心脏的足够血供。一氧化氮的另一个重要作用就是减慢动脉粥样硬化斑块在血管壁的沉积。我的研究强烈提示利用一氧化氮可以拮抗动脉粥样硬化斑块的形成。 相似文献
90.
声学多孔材料的孔结构优化 总被引:1,自引:0,他引:1
介绍了一种基于微结构的声学模型,可用来对多孔材料的微组织结构进行优化,从而使多孔材料具备最佳的声学性能.该模型是一种适用于低雷诺数的非稳态线性声学模型,主要微结构考虑平行排列的柱形杆件或圆球列阵,包括3个子模型:①声波传播方向平行于圆柱形杆件的子模型;②声波传播方向垂直于圆柱形杆件的子模型;③声波在圆球列阵中传播和吸收的子模型.前2个子模型通过考虑多边形周期边界条件的影响,计及了相邻圆柱形杆件间的交互作用.由于模型是线性的,因此可以结合起来描述任意角度入射声波的传播特性.第3个子模型可用于描述胞状多孔材料中节点处的情形.文中利用这3个子模型来扩大吸声材料的设计空间,根据不同用途所要求的声学特性计算最优的胞元结构,并对这种模型的应用领域进行了分析讨论. 相似文献