Atomic structure and chemistry of human serum albumin.

The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.     

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

A genomic sequence close to the cystic fibrosis locus with the characteristics of an HTF island has been selectively cloned and characterized. Two markers flanking this sequence, which is conserved throughout mammalian evolution, show a very much greater disequilibrium than that found with any existing marker. A single mutational event accounts for most cases of cystic fibrosis. The sequence is expressed, and is a candidate for the cystic fibrosis gene.     

Long-term potentiation of electrotonic coupling at mixed synapses

Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has not been described. Here we report that at mixed synapses between sensory afferents and an identified reticulospinal neuron, the electrotonic coupling potential can be potentiated, as well as the chemically mediated excitatory postsynaptic potential, for a prolonged time period using a stimulation paradigm like that which produces long-term potentiation in hippocampus. The effect on coupling is due to an increase in gap-junctional conductance. Our data indicate that the potentiation of both synaptic components requires an increase in intracellular calcium, involves activation of NMDA (N-methyl-D-aspartate) receptors, and is specific to the tetanized pathway.     

国有企业委托—代理问题探析

从《制度经济学》中有关企业的委托—代理问题出发，阐述了我国国企目前的状况，通过分析其原因，提出了解决国有企业委托—代理问题的思路。     

Research Frontiers of Agricultural Economics and Management

Introduction 　　The focus of research on Agricultural Economics and Management (AEM) has been switching from developed countries to developing countries. In important international journals on AEM such as “American Journal of Agricultural Economics“ and “Agricultural Economics“, the research objectives mainly focus on AEM problems in developing countries, e.g. the effects of globalization and liberalization on agricultural production in developing countries, and problems in agricultural resources and environmental protections in developing countries. 　　……     

分流模型PID与鲁棒补偿的复合控制策略

提出了一种基于分流模型PID与鲁棒补偿的复合控制策略，这种控制器具有非线性滤波、增益自调整、鲁棒性好等优良特性。由于分流模型的输出是稳定、光滑且有界，可以构造一类具有输出光滑、有界并且增益自调整的PID控制器，其可设计一类安全控制系统．将分流模型PID与鲁棒补偿控制相结合，有效地解决了参数不确定情况下的一类非线性系统的鲁棒控制问题。通过倒立摆控制系统的仿真研究，验证了控制策略的有效性。     

Fuzzy State Comprehensive Evaluation of Living Basis for Small Businesses

The problem of comprehensive evaluation of living basis for small businesses is discussed, based on fuzziness of index, a corresponding fuzzy state comprehensive evaluation method is presented; the good results that is, the evaluation of living basis for small business are illustrated by a simulated example.     

Fabrication and Properties of CoSm-Based Multilayer Thin Films

In recent years, SmCo series thin films have been found to be good candidates for fabricating integrated electromagnetic components and ultrahigh density magnetic recording media[1,2]. Up to now,intensive studies of such films have been carried out in order to obtain appropriate microstructure, crystallographic orientation and other properties. Substitution of Cu or Ni for Co in SmCo/Cr series films leads to a decrease of the saturation magnetization, magnetic switching volume, and to an increase of uniaxial anisotropy and coercivity[3-5].Various deposition conditions have also been investigated[6]. The large increase in coercivity for the annealed SmCo/Cr films is due to the growth of crystallitest[7,8]. In this article, we report a study of the deposition process,structure, and magnetic behavior of sputtered Sm (Co,Cu, Ti)/Cr series thin films.……