Entry of water,metabolic substrates and extracellular space markers into various structures of mouse brain in vivo

Résumé Une méthode nouvelle est présentée pour étudier des corrélations qui existent entre le cerveau et le comportement des animaux.

---

---

This study was supported in part by a grant from the Eli Lilly Company.     

Comparative habitat and community relationships of Atriplex confertifolia and Sarcobatus vermiculatus in central Utah

Thirty-four study sites were established in shadscale ( Atriplex confertifolia [Torr. & Frem.] Wats.) and greasewood ( Sarcobatus vermiculatus [Hoov. Torr. in Emory) communities bordering Utah Lake in central Utah. Differences in species composition, vegetation, and soil characteristics were assessed. Significant differences in soil factors between the two communities were found for sand, calcium, manganese, zinc, and copper. Soluble salts and sodium concentrations were generally higher in the greasewood type, but differences were not significant. Major differences were found in understory species, with burr buttercup ( Ranunculus testiculatus Grantz) showing significantly greater cover in the shadscale community and cheatgrass ( Bromus tectorum L.) showing significantly greater cover in the greasewood community.     

Population structure and paternity in an American black bear ( Ursus americanus ) population using microsatellite DNA

We report genetic microsatellite data from analysis of 71 American black bears ( Ursus americanus ) from the East Tavaputs Plateau in eastern Utah. Heterozygosity was 52.9%, which is lower than other mainland North American populations and possibly reflects low recruitment into the study area. We used a combination of known pedigrees (mother/cubs), relatedness estimates, and paternity estimation using CERVUS to infer single and possible multiple paternity within litters, breeding by pairs over consecutive years, and the possibility of a single male successfully breeding with multiple females in a single year. Estimates of inbreeding effective population size indicate the East Tavaputs Plateau population is part of a larger black bear population.     

Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes

Donnai-Barrow syndrome is associated with agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. By studying multiplex families, we mapped this disorder to chromosome 2q23.3-31.1 and identified LRP2 mutations in six families with Donnai-Barrow syndrome and one family with facio-oculo-acoustico-renal syndrome. LRP2 encodes megalin, a multiligand uptake receptor that regulates levels of diverse circulating compounds. This work implicates a pathway with potential pharmacological therapeutic targets.