高血压病肾脏损害的临床因素：（附76例分析）

在３３８例原发性高血压患者中，发现有肾脏损害（尿改变和／或肾功能不全）者７６例，发生率为２２．４９％，分析结果显示出高血压患者的年龄愈大，病程愈长，血压程度愈高，其肾损害发生率亦愈高；且肾损害发生率与舒张压程度、持续时间成正比，提示了肾损害发生与动脉硬化有关。结果还显示了其肾损害程度较轻，以及早期和持续降压治疗对预防发生不可逆的严重肾损害，降低病死率的重要性。     

双层钢箱截面组合索塔力学性能试验

设计制作了5个具有开孔板连接件和5个具有焊钉连接件的双层钢箱截面钢-混凝土组合索塔模型试件,根据索塔实际受力特性进行轴压和恒定轴力下的往复弯曲荷载试验.试验展示了使用两类连接件的双层钢箱组合索塔在不同荷载作用下的破坏形态和极限能力,结果表明:开孔板和焊钉均能约束受压钢板的屈曲波长,连接件的类型对试件破坏的具体形态有一定影响;轴压比是影响试件力学性能的主要因素,所有试件都根据其大小分为受压破坏和受拉破坏两类;无轴力和过高的轴力都会明显降低构件在往复荷载下的力学性能.最后,将试验结果与按照基于刚塑性原理的规范计算得到的承载能力进行比较.     

矩阵表示的子空间学习算法综述

线性子空间学习是较为流形的一种特征提取方法,而向量表示的子空间学习方法则是目前众多线性子空间学习方法之一.近年来人们针对这一方法的缺点和不足,提出了若干矩阵表示的子空间学习方法,这些方法都是向量表示的子空间学习方法的拓展.首先介绍了几种经典的向量表示子空间学习方法,进而对几种有代表性的矩阵表示子空间学习方法进行了综述并比较详尽地给出了这些算法的推导过程,同时对算法的有效性等问题进行了分析比较,提出了一些新的理论观点和见解.     

齐墩果酸衍生物的合成与表征及其抑菌活性的研究

齐墩果酸属于五环三萜类化合物,在自然界中分布广泛,并显示出多种生物活性,如:保肝、抗炎、抗病毒、抗癌等多种药理作用,并具有良好的抑菌活性.因此本文以齐墩果酸为先导化合物,对其结构进行了修饰,合成4个中间体和6个新的目标产物,并经过IR、1 H NMR波谱测试技术对其结构进行了表征.并以其对培养于MHB(高铁血红蛋白)的S.a(金黄色葡萄球菌)4220、S.a(金黄色葡萄球菌)209、MRSA(抗甲氧西林金黄色葡萄球菌)3167、MRSA(抗甲氧西林金黄色葡萄球菌)3506、QRSA(抗喹诺酮金黄色葡萄球菌)3505、QRSA(抗喹诺酮金黄色葡萄球菌)3519和培养于BHI中的E.coli(大肠杆菌)1682、E.coli(大肠杆菌)1356等8种菌种进行抑菌活性测试,结果表明,部分化合物的抑菌活性较标准抗菌药物有明显提高.     

基于移位和异或的最佳扩散变换的构造

扩散结构的好坏直接影响了分组密码的扩散速度和安全强度,以分支数尽可能大的线性变换为分组密码算法的扩散结构是设计分组密码的一种重要方法,线性变换的构造可通过可逆矩阵的构造完成.利用高效的算法搜索出几类可逆广义字变换,在此基础上提出一类计算上可行的基于GF(232)上移位和比特异或的最佳扩散变换构造的算法.该变换特别适合硬件实现,广泛用于分组、序列以及HASH等密码算法的设计中.     

基于旁路分析的硬件木马检测方法

集成电路芯片在不受控的制造过程中可能会被嵌入恶意电路结构,形成硬件木马,这给集成电路芯片的可靠性和可信度带来了极大的隐患,而利用传统的测试技术很难发现这些硬件木马.针对这一问题,文中提出了一种非破坏性的、基于旁路分析的硬件木马检测方法,它通过对芯片功耗瞬态变化情况的分析,采用奇异值分解算法对功耗进行统计处理来检测芯片中的硬件木马.在FPGA芯片上的硬件验证结果表明,即使在测量噪声和工艺扰动较大的环境中,文中方法也能检测出面积比原始电路小2个数量级的硬件木马.     

降雨对棒板(棒棒)空气间隙交流放电特性的影响

针对近年来我国输电线路频繁出现风偏闪络事故,分析认为暴雨是造成输电线路风偏闪络的原因之一。通过模拟降雨试验研究降雨强度、雨水电阻率、环境温度对棒板(棒棒)空气间隙交流放电特性的影响。试验结果表明：降雨强度、雨水电阻率均使棒板(棒棒)空气间隙交流放电电压降低,其中降雨强度对棒板空气间隙交流放电电压的影响最明显;降雨强度I=2~14 mm/min时,棒板间隙距离d=0.4、0.6、0.7 m的交流放电电压最大降低幅度分别为6.73%、6.54%、6.02%,而棒棒间隙的最大降低幅度分别为2.66％、3.22%、3.07%;降雨强度对棒板交流放电电压影响大,对棒棒影响小;暴雨情况下环境温度的升高使棒板空气间隙交流放电电压升高,其最大变化幅度为7.03%。     

Spatial discretization error in an artificial benchmark model of oblique laser incidence by finite volume approximation for radiative heat transfer

The spatial discretization error in a finite volume method approximation for radiative heat transfer is investigated. An artificial benchmark model for oblique laser incidence on a two-dimensional rectangle containing a semi-transparent medium is proposed, in addition to using reference data from the Monte Carlo method. Within the framework of the current model, it is shown that numerical scattering in the finite volume method is affected by the spatial grid values and the different spatial discretization schemes to a large degree. Numerical scattering also varies with the degree of absorption coefficient deviation. Numerical scattering is distributed in a symmetrical profile along the laser incidence direction, and all of the schemes show symmetrical cross-scattering.     

Phosphonylation and aging mechanisms of mipafox and butyrylcholinesterase: A theoretical study

Phosphonylation and aging processes between butyrylcholinesterase with mipafox have been studied at the B3LYP/6-311G(d,p) level of theory. The calculated results indicate that the phosphonylation process employs a two-step addition-elimination mechanism with the addition (the first step) as the rate-limiting step. Two different calculation models revealed that the catalytic triad of butyrylcholinesterase plays an important role in accelerating the reaction. This is the same mechanism as the phosphonylation reaction of acetylcholinesterase by sarin reported by Wang et al. However, the energy barrier of the rate-limiting step in the present reaction is higher than that in phosphonylation reaction of acetylcholinesterase by sarin. This indicates the differences in the phosphonylation activity of sarin and mipafox. The aging process occurs through a two-step addition-elimination mechanism similar to the phosphonylation process with the addition as the rate-limiting step. The solvent effects have been evaluated by using a CPCM model and the results show that the stationary structures and the negative charges around some important atoms involved in the two processes are not significantly different. However, the energy barrier of the phosphonylation process is remarkably decreased, revealing that this process is feasible in solution.