基于空间自适应全变分的图像配准

通过引入空间自适应正则化参数,建立了离散的空间自适应全变分配准模型,并结合一阶泰勒展开式给出了有效的不动点求解方法.实验结果表明,由空间自适应全变分配准模型得到的图像的质量比全变分配准模型的更好,迭代时间更短.     

工程建设用地综合评价数学模型的研究

将多目标决策的效用函数法运用于工程建设用地综合评价数学模型中，能够有机地将专家的＂定量＂和＂定性＂知识结合起来，得出较为切合实际的结果，利用“层次分析法”将工程建设用地综合评价牵涉的众多影响因素，划分为不同层次并根据专家经验将其“定量”化，评价结果可根据目标值直观地得出，最后用案例验证该数学模型的适用性和可靠性。     

基于数据挖掘的蔬菜图片病害自动分类

为了对蔬菜病害进行自动检测和分级,克服传统的评估方法检测成本高、划分等级随意性比较大的缺陷,探讨了基于蔬菜图像的病害等级自动分类,设计了预处理技术提取图片特征.具体方法是对叶片图像进行分割并转变为分布概率的灰度矢量.在此基础上利用数据挖掘技术建立决策树模型,利用该模型对未分级叶片的级别进行预测.还引入了元挖掘算法Bagging,与决策树模型综合使用,进一步提高了预测效果.实验表明这一蔬菜病害等级自动分类方法准确度较高,具有较好的实用价值.     

柔性高桩承台与桩基的有限元分析

提出柔性高桩承台与桩基计算的一种有限单元法，其计算模型不仅将承台和桩基作为刚性联结的整体结构来分析，且考虑桩土间相互作用，可用于任意动、静荷载作用下结构的位移与内力计算．     

玉米粉直接发酵生产L－乳酸钙

以米根霉（ＲｈｉｚｏｐｕｓＯｒｙｚａｅ）突变株Ｒ－１８８为菌种，直接用玉米粉为原料，在７００Ｌ发酵罐连续进行四批Ｌ－乳酸钙生产试验．平均发酵单耗为每ｋｇＬ－乳酸钙耗玉粉１．０３ｋｇ；平均产酸０．９５２ｍｏｌ·Ｌ－１，产酸速率为１．１８ｇ·Ｌ－１·ｈ－１．Ｌ－乳酸钙平均提取率为８１．８％．     

Distribution of highly repeated DNA sequences in Haynaldia villosa and its application in the identification of alien chromatin

Haynaldia villosa (L.) is a wild relative species of common wheat that possesses many beneficial genes that can be used for wheat improvement. The accurate detection of H. villosa chromosomes in the genetic background of wheat is critical for transferring its beneficial genes to common wheat by chromosome engineering. The aim of the present study was to investigate the distribution patterns of two repeated DNA sequences, pSc119.2 and pAs1, as well as two rDNA multigene family sequences, 45S rDNA and 5S rDNA, in the individual chromosomes of H. villosa for the future precise identification of alien chromatin in germplasm development and breeding programs. A set of common wheat-H. villosa disomic addition 1V-7V lines was used to determine these specific signals on individual chromosomes of H. villosa. The results showed that two rDNA probes, pTa71 (45S rDNA) and pTa794 (5S rDNA), were located on 1VS and 5VS, respectively, and the signal could be discriminated exclusively in the common wheat background as effective markers of 1VS and 5VS. Furthermore, all seven chromosomes of H. villosa could be distinguished clearly by fluorescence in situ hybridization using pSc119.2 and pAs1 as probes in combination. The utilization of these cytogenetic markers of repetitive sequences, combined with other molecular markers sometimes, will make it possible for a precise identification of alien chromosomes with high efficiency.     

考虑地应力修正的岩体损伤评价

传统的岩体质量评价体系不考虑或仅从破坏角度考虑地应力的影响.为了反映岩体损伤演化过程,针对深部岩体在自重应力场和构造应力场的作用情况,提出地应力的修正计算方法;根据Mohr-Coulomb准则,引入破坏接近度的概念,提出修正地应力造成的岩体损伤评价方法,并与岩体损伤破坏评价5个等级对应,建立了Q值与岩体损伤等级对应关系.     

几乎一切Mersenne数与Fermat数都是素数

在本文中,我们用模型论方法证明:几乎一切Mersenne数与Fermat数都是素数.     

关于整数环的无限n素元组归纳扩环的多样性

用模型论方法证明了: 对于整数环I及每个正整数n及每一可能类型的n素元组而言,存在不可数无限多个其1阶性质互不全同的含有无限多该类型的n素元组的归纳扩环(文中简称该类型的nT-环),并且存在无限多个正整数对,对每个这样的正整数对(a,b),存在I的nT-扩环R,它适合加a的归纳法,而不适合加b的归纳法. 还证明了存在该类型的nT-环R,R的每个元素是3平方和和4立方和.     

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression

Menkes disease (MD) is an X-linked recessive disorder characterized by copper deficiency resulting in a diminished function of copper-dependent enzymes. Most MD patients die in early childhood, although mild forms of MD have also been described. A diversity of mutations in the gene encoding of the Golgi-resident copper-transporting P_1B-type ATPase ATP7A underlies MD. To elucidate the molecular consequences of the ATP7A mutations, various mutations in ATP7A associated with distinct phenotypes of MD (L873R, C1000R, N1304S, and A1362D) were analyzed in detail. All mutants studied displayed changes in protein expression and intracellular localization parallel to a dramatic decline in their copper-transporting capacity compared to ATP7A the wild-type. We restored these observed defects in ATP7A mutant proteins by culturing the cells at 30°C, which improves the quality of protein folding, similar to that which as has recently has been demonstrated for misfolded ATP7B, a copper transporter homologous to ATP7A. Further, the effect of the canine copper toxicosis protein COMMD1 on ATP7A function was examined as COMMD1 has been shown to regulate the proteolysis of ATP7B proteins. Interestingly, in addition to adjusted growth temperature, binding of COMMD1 partially restored the expression, subcellular localization, and copper-exporting activities of the ATP7A mutants. However, no effect of pharmacological chaperones was observed. Together, the presented data might provide a new direction for developing therapies to improve the residual exporting activity of unstable ATP7A mutant proteins, and suggests a potential role for COMMD1 in this process.