如何提高机床结构的动刚度

为了改善机床的刚性和提高机床的精度,从分析机床结构的振动类型及影响机床结构动刚度的因素入手;从合理设计结构的断面形状和尺寸、改善构件间的联接刚度、合理选择构件的壁厚、开口的大小及位置、内腔充填阻尼材料、表面增加阻尼涂层、改变振型方向等几个方面阐述了提高机床结构刚度的方法,从而为机床的优化设计提供依据.     

Across-shore distribution of Ocypode quadrata burrows in relation to beach features and human disturbance

Spatial distribution patterns of the ghost crab Ocypode quadrata were analysed using different approaches at one disturbed and two preserved reflective sandy beaches of the Mexican Caribbean. We used spatial correlation analysis to describe the across-shore distribution of O. quadrata and their patch dynamics by beach and sampling time. In addition, we analysed the across-shore variability of habitat extent of O. quadrata (habitat envelope) and its relation to human disturbance and beach features. The spatial structure of burrow density was consistent through time, showing a bimodal distribution with very low abundance in the mid distribution range and a discrete increment of burrows to landward. Nonetheless, the size of patches varied temporally for the three beaches. Burrow size increased from seaward to landward. The location of the first burrow and the habitat envelope varied among sampling times and beaches. The location of the first burrow is mostly mediated by the swash climate, while the habitat envelope is mainly controlled by the level of human disturbance. Despite the low number of disturbed and control beaches, our results suggest that the habitat envelope could be included in future studies when using ghost crabs as indicators of human disturbance. Polynomial models and variographic analysis proved to be useful tools to describe the across-shore distribution and patch dynamics of the ghost crab.     

Polycystins and cellular Ca2+ signaling

The cystic phenotype in autosomal dominant polycystic kidney disease is characterized by a profound dysfunction of many cellular signaling patterns, ultimately leading to an increase in both cell proliferation and apoptotic cell death. Disturbance of normal cellular Ca²⁺ signaling seems to be a primary event and is clearly involved in many pathways that may lead to both types of cellular responses. In this review, we summarize the current knowledge about the molecular and functional interactions between polycystins and multiple components of the cellular Ca²⁺-signaling machinery. In addition, we discuss the relevant downstream responses of the changed Ca²⁺ signaling that ultimately lead to increased proliferation and increased apoptosis as observed in many cystic cell types.     

Why Do Students Leave Education Early? Theory and Evidence on High School Dropout Rates

This paper contributes to the growing literature on school dropout by proposing and empirically testing a theoretical framework on the enrollment decision of youngsters in secondary education. The model relates school dropout to time preferences, motivation, opportunity costs and policy measures. It is empirically tested on longitudinal data of about 4000 Dutch vocational students. We evaluate the enrollment decision of students for (i) different intensity levels of dropout prevention policy, and for (ii) different levels of economic development. The results indicate that the model can accurately predict actual enrollment rates over the period 2000–2013. Copyright © 2016 John Wiley & Sons, Ltd.