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排序方式: 共有147条查询结果,搜索用时 15 毫秒
91.
Gemoll T Roblick UJ Szymczak S Braunschweig T Becker S Igl BW Bruch HP Ziegler A Hellman U Difilippantonio MJ Ried T Jörnvall H Auer G Habermann JK 《Cellular and molecular life sciences : CMLS》2011,68(19):3261-3274
DNA aneuploidy has been identified as a prognostic factor for epithelial malignancies. Further understanding of the translation of DNA aneuploidy into protein expression will help to define novel biomarkers to improve therapies and prognosis. DNA ploidy was assessed by image cytometry. Comparison of gel-electrophoresis-based protein expression patterns of three diploid and four aneuploid colorectal cancer cell lines detected 64 ploidy-associated proteins. Proteins were identified by mass spectrometry and subjected to Ingenuity Pathway Analysis resulting in two overlapping high-ranked networks maintaining Cellular Assembly and Organization, Cell Cycle, and Cellular Growth and Proliferation. CAPZA1, TXNL1, and HDAC2 were significantly validated by Western blotting in cell lines and the latter two showed expression differences also in clinical samples using a tissue microarray of normal mucosa (n?=?19), diploid (n?=?31), and aneuploid (n?=?47) carcinomas. The results suggest that distinct protein expression patterns, affecting TXNL1 and HDAC2, distinguish aneuploid with poor prognosis from diploid colorectal cancers. 相似文献
92.
93.
K. L. Becker O. L. Silva J. Cyrus R. H. Snider Jr. C. F. Moore 《Cellular and molecular life sciences : CMLS》1980,36(11):1330-1331
Summary Gastrin has been suggested as a natural secretogogue of the hormone calcitonin. We have found hypercalcitonemia in 55% of patients with pernicious anemia, and the gastrin levels, although usually increased, did not correlate. 相似文献
94.
95.
96.
H. W. Becker 《Cellular and molecular life sciences : CMLS》1965,21(12):719-719
Zusammenfassung Im zweiten Abdominalganglion der Indischen Stabheuschrecke (Carausius morosus Br.) wurden 600 ± 50 Neurone, 1000 ± 100 Gliazellen und 500 ± 30 Perineuriumzellen, zusammen etwa 2100 Zellen gezählt. Die Volumina des Ganglions, des Neuropilems und des Zellcortex betrugen etwa: 140 · 10–4 mm3, 75 · 10–4 mm3 und 65 · 10–4 mm3. 相似文献
97.
Fisher AT Davis EE Hutnak M Spiess V Zühlsdorff L Cherkaoui A Christiansen L Edwards K Macdonald R Villinger H Mottl MJ Wheat CG Becker K 《Nature》2003,421(6923):618-621
Hydrothermal circulation within the sea floor, through lithosphere older than one million years (Myr), is responsible for 30% of the energy released from plate cooling, and for 70% of the global heat flow anomaly (the difference between observed thermal output and that predicted by conductive cooling models). Hydrothermal fluids remove significant amounts of heat from the oceanic lithosphere for plates typically up to about 65 Myr old. But in view of the relatively impermeable sediments that cover most ridge flanks, it has been difficult to explain how these fluids transport heat from the crust to the ocean. Here we present results of swath mapping, heat flow, geochemistry and seismic surveys from the young eastern flank of the Juan de Fuca ridge, which show that isolated basement outcrops penetrating through thick sediments guide hydrothermal discharge and recharge between sites separated by more than 50 km. Our analyses reveal distinct thermal patterns at the sea floor adjacent to recharging and discharging outcrops. We find that such a circulation through basement outcrops can be sustained in a setting of pressure differences and crustal properties as reported in independent observations and modelling studies. 相似文献
98.
Hillier LW Fulton RS Fulton LA Graves TA Pepin KH Wagner-McPherson C Layman D Maas J Jaeger S Walker R Wylie K Sekhon M Becker MC O'Laughlin MD Schaller ME Fewell GA Delehaunty KD Miner TL Nash WE Cordes M Du H Sun H Edwards J Bradshaw-Cordum H Ali J Andrews S Isak A Vanbrunt A Nguyen C Du F Lamar B Courtney L Kalicki J Ozersky P Bielicki L Scott K Holmes A Harkins R Harris A Strong CM Hou S Tomlinson C Dauphin-Kohlberg S Kozlowicz-Reilly A Leonard S Rohlfing T Rock SM Tin-Wollam AM Abbott A 《Nature》2003,424(6945):157-164
99.
Rifampicin--a new antitrachoma drug 总被引:9,自引:0,他引:9
100.
Andrés E Askebjer P Bai X Barouch G Barwick SW Bay RC Becker KH Bergström L Bertrand D Bierenbaum D Biron A Booth J Botner O Bouchta A Boyce MM Carius S Chen A Chirkin D Conrad J Cooley J Costa CG Cowen DF Dailing J Dalberg E DeYoung T Desiati P Dewulf JP Doksus P Edsjö J Ekström P Erlandsson B Feser T Gaug M Goldschmidt A Goobar A Gray L Haase H Hallgren A Halzen F Hanson K Hardtke R He YD Hellwig M Heukenkamp H Hill GC Hulth PO Hundertmark S Jacobsen J Kandhadai V Karle A Kim J Koci B Köpke L 《Nature》2001,410(6827):441-443
Neutrinos are elementary particles that carry no electric charge and have little mass. As they interact only weakly with other particles, they can penetrate enormous amounts of matter, and therefore have the potential to directly convey astrophysical information from the edge of the Universe and from deep inside the most cataclysmic high-energy regions. The neutrino's great penetrating power, however, also makes this particle difficult to detect. Underground detectors have observed low-energy neutrinos from the Sun and a nearby supernova, as well as neutrinos generated in the Earth's atmosphere. But the very low fluxes of high-energy neutrinos from cosmic sources can be observed only by much larger, expandable detectors in, for example, deep water or ice. Here we report the detection of upwardly propagating atmospheric neutrinos by the ice-based Antarctic muon and neutrino detector array (AMANDA). These results establish a technology with which to build a kilometre-scale neutrino observatory necessary for astrophysical observations. 相似文献