Natriferic and hydroosmotic potencies of deamino-oxytocin analogues with no disulphide bridge

Résumé Des analogues déaminés de l'ocytocine, dans lesquels l'atome de S en position 1, 6 ou 1 et 6 a été remplacé par un radical CH₂, de même que des analogues déaminés dont la partie cyclique a été raccourcie ou allongée, restent capables d'augmenter la perméabilité à l'eau de la vessie ou le transport actif du sodium par la peau de la grenouille. L'ensemble des substitutions étudiées réduit de mainère importante (85 à 300 fois) l'affinité du peptide pour son récepteur et affecte de manière variable son activité intrinsèque.

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Scientifique.     

Quality vs. quantity of publications in nanotechnology field from the People’s Republic of China

This study evaluates trends in quality of nanotechnology and nanoscience papers produced by authors from the People＇s Republic of China （PRC）. The metric used to gauge quality is ratio of highly cited nanotechnology papers to total nanotechnology papers produced in sequential time frames. The USA is both the most prolific nanotechnology publishing country and most represented country on highly cited nanotechnology papers （both in absolute numbers of highly cited papers and highly cited papers relative to total publications） over the 1998-2003 time frame, based on the SCl/SSCl databases. Some of the smaller hi-tech countries have relatively high ratios （-2） of highly cited papers to total publications （e.g. Denmark, Netherlands, Switzerland）. Countries that have exhibited rapid growth in SCl/SSCl nanotechnology paper production in recent years （e.g. PRC, South Korea） had ratios an order of magnitude less than that of the USA for 1998, but by 2003 had increased to about 20% that of the USA （-2.5）. PRC and South Korea have climbed in the publications rankings from 6th and 9th in 1998, respectively, to 2nd and 6th in 2005, respectively. PRC＇s ratio monotonically increased from 0.16 to 0.45 over the 1998-2003 period, and South Korea＇s ratio increased from 0.11 to about 0.6 over that same period, indicating their papers are getting more and more citations proportionately. Thus, under rapid growth conditions, PRC and South Korea have been able to increase their share of participation in highly cited papers. As of 2003, PRC and South Korea have ratios comparable to nations like Japan, France, Italy, and Australia but not yet approaching those of the highly cited countries. None of the top ten publications producing institutions are from the USA, while all of the top ten highly cited publications producers are from the USA. Over the 1998-2003 time period, the top six total publications producing institutions （globally） remained the same, with Chinese Academy of Sciences （which consists