Deliberative Inquiry: Integrated Ways of Working in Children Services

In striving for greater integration of children services across a number of government and non government agencies, this paper examines the effect of drawing on deliberative inquiry as the lever for realising greater alignment across agencies. The paper discusses the need for improvement in UK local government children??s services and then offers a review of the dialogue based inquiry approaches. In so doing, the paper highlights the Socratic mode of inquiry, emphasising the dual strategies of penetrative questioning, elenchus, and the process of founding new knowledge through working through confusion, aporia. This paper then reports how a London borough realised sustained change through the adoption of deliberative inquiry. The study achieved successful integration through the penetrating and contextually sensitive dialogue the inquiry participants generated, allowing them to develop the capability for realising effective organisational change. The paper concludes that deliberative inquiry facilitates individuals to speak their concerns in a manner that prompts ??consensually accepted beliefs?? to emerge through paying equal attention to the motivation of the inquiry participants, as well as to the reality of the contextual demands they need to confront.     

An isoform of the vacuolar (H+)-ATPase accessory subunit Ac45

The vacuolar (H⁺)-ATPase (V-ATPase) is the main regulator of intraorganellar pH and in neuroendocrine cells is controlled by its accessory subunit, Ac45. Here, we report the discovery of the first isoform of a V-ATPase accessory subunit, namely an Ac45-like protein, denoted Ac45LP. Phylogenetic analysis revealed a lineage-dependent evolutionary history: Ac45 is absent in birds, and Ac45LP is absent in placental mammals, whereas all other tetrapod species contain both genes. In contrast to Ac45, Ac45LP is not proteolytically cleaved, a prerequisite for proper Ac45 routing. Intriguingly, Xenopus Ac45LP mRNA was expressed in developing neural tissue and in neural crest cells. In adult Xenopus, Ac45 mRNA is widely expressed mostly in neuroendocrine tissues, while Ac45LP mRNA expression was found to be restricted to the kidney and the lung. This novel Ac45LP may provide additional possibilities for V-ATPase regulation during neurodevelopment as well as in kidney and lung cells.     

The bonobo genome compared with the chimpanzee and human genomes

Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key social and sexual behaviours, and for some of these traits they show more similarity with humans than with each other. Here we report the sequencing and assembly of the bonobo genome to study its evolutionary relationship with the chimpanzee and human genomes. We find that more than three per cent of the human genome is more closely related to either the bonobo or the chimpanzee genome than these are to each other. These regions allow various aspects of the ancestry of the two ape species to be reconstructed. In addition, many of the regions that overlap genes may eventually help us understand the genetic basis of phenotypes that humans share with one of the two apes to the exclusion of the other.     

Millennial and orbital variations of El Niño/Southern Oscillation and high-latitude climate in the last glacial period

The El Ni?o/Southern Oscillation (ENSO) phenomenon is believed to have operated continuously over the last glacial-interglacial cycle. ENSO variability has been suggested to be linked to millennial-scale oscillations in North Atlantic climate during that time, but the proposals disagree on whether increased frequency of El Ni?o events, the warm phase of ENSO, was linked to North Atlantic warm or cold periods. Here we present a high-resolution record of surface moisture, based on the degree of peat humification and the ratio of sedges to grass, from northern Queensland, Australia, covering the past 45,000 yr. We observe millennial-scale dry periods, indicating periods of frequent El Ni?o events (summer precipitation declines in El Ni?o years in northeastern Australia). We find that these dry periods are correlated to the Dansgaard-Oeschger events--millennial-scale warm events in the North Atlantic climate record--although no direct atmospheric connection from the North Atlantic to our site can be invoked. Additionally, we find climatic cycles at a semiprecessional timescale (approximately 11,900 yr). We suggest that climate variations in the tropical Pacific Ocean on millennial as well as orbital timescales, which determined precipitation in northeastern Australia, also exerted an influence on North Atlantic climate through atmospheric and oceanic teleconnections.