A microRNA polycistron as a potential human oncogene

To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.     

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

TRF2 is a telomere-binding protein that has a role in telomere protection. We generated mice that overexpress TRF2 in the skin. These mice had a severe phenotype in the skin in response to light, consisting of premature skin deterioration, hyperpigmentation and increased skin cancer, which resembles the human syndrome xeroderma pigmentosum. Keratinocytes from these mice were hypersensitive to ultraviolet irradiation and DNA crosslinking agents. The skin cells of these mice had marked telomere shortening, loss of the telomeric G-strand overhang and increased chromosomal instability. Telomere loss in these mice was mediated by XPF, a structure-specific nuclease involved in ultraviolet-induced damage repair and mutated in individuals with xeroderma pigmentosum. These findings suggest that TRF2 provides a crucial link between telomere function and ultraviolet-induced damage repair, whose alteration underlies genomic instability, cancer and aging. Finally, we show that a number of human skin tumors have increased expression of TRF2, further highlighting a role for TRF2 in skin cancer.     

鄂博梁Ⅲ号构造上、下油砂山组成岩作用及对孔隙影响

根据砂岩普遍薄片、铸体薄片、扫描电镜和其他化验资料等,系统研究柴达木盆地北缘地区鄂博梁Ⅲ号构造的岩石学特征、成岩作用及对孔隙的影响.结果表明:研究区储集砂岩较细,以细砂岩和粉砂岩为主,含少量中砂岩和粗砂岩;岩石类型主要为长石砂岩和岩屑长石砂岩,含少量长石岩屑砂岩.成岩作用主要为压实作用、胶结作用和溶蚀作用,成岩作用阶段已经达到晚成岩阶段A期.压实作用中等是孔隙度大量丧失的主要原因.胶结作用较强,胶结物主要有碳酸盐胶结物、硫酸盐胶结物、硅质胶结和黏土矿物胶结,胶结物充填孔隙、堵塞喉道,在成岩早期能起骨架支撑缓解压实作用的进行.溶蚀作用中等,主要为长石、岩屑、碳酸盐胶结物及杂基等易溶组分溶蚀成粒间、粒内溶蚀孔,为储层增加次生孔隙,属于建设性成岩作用.     

铝合金表面有色钛/锆转化膜的成膜机理及性能

为了解决工业生产中钛/锆转化膜无色的问题,通过向含钛/锆的处理液中加入单宁酸及成膜促进剂,在铝合金表面制备了有色钛/锆转化膜.采用X射线能谱仪、扫描电镜、傅里叶变换红外光谱仪、X射线衍射仪、X射线光电子能谱仪和电化学工作站对转化膜的形成过程、形貌、组织结构、耐蚀性等进行了分析.结果表明:在铝合金表面成功制备出了金黄色、耐蚀性优异的转化膜,其主要成分是Na3AlF6,其次是单宁酸水解产物的金属络合物以及少量Al2O3.3H2O、TiO2等;膜的形成可分为Na3AlF6晶体成核、生长和金属络合物的沉积3个阶段;转化膜的腐蚀电流密度由基体的5.894μA/cm2下降到0.283μA/cm2,耐蚀性明显提高.     

两台平行机上链约束下单位长度工件完工时间平方和最小的在线排序问题

研究了两台平行机上链约束下单位长度工件完工时间平方和最小的在线排序问题,要求在整数时刻到达工件,整数时刻开始加工工件,当然也会在整数时刻完工工件.利用对手法证明任一实例在任意算法下竞争比不小于5/4,而任意的稠密算法的竞争比都渐近地趋于2;其次找到一种稠密算法—层次算法,其竞争比为2,从而说明此层次算法为本问题的一个最好可能在线稠密算法.     

黎明国家地质公园丹霞景观特征及成因分析

阐述了黎明国家地质公园丹霞地貌景观类型及其特征,通过对该区野外调查及分析,发现红层岩性软弱差异、新构造运动、流水侵蚀、崩塌等内外力作用是造成该地区丹霞地貌景观差异的主要原因.     

一种基于转交效用的多副本机会网络路由协议

为了提高机会网络的传输效率,该文在分析现有“存储-携带-转发”传输模型的的基础上,提出一种基于转交效用的多副本传输方法.该方法根据节点历史相遇的时间和空间信息计算节点的递交概率预测值,并将其应用到散发策略和转发递交策略中,使节点在选择下一跳节点时能够预先判断其到达目的节点的效率,从而选择一条最优路径,提高了副本投递的能力.仿真结果表明,该路由算法具有较高的报文成功递交率、较低的平均网络延时,以及较低的网络开销,适合于通信不稳定的机会网络.     

芦荟的研究进展

芦荟是一种经济价值很高的药用植物.本文对芦荟的化学成分、药理作用作了综述,并对芦荟的开发利用及其产业发展前景作了介绍.     

基于作战环的导弹武器系统体系相对贡献率评估

基于作战环理论,从节点、边、环等层次建立武器装备体系作战网络模型,并结合蒙特卡罗方法,提出一套高效的体系相对贡献率评估方法。针对典型作战想定,研究两种导弹不同发射数目对突防和毁伤概率的影响。仿真结果表明:导弹的突防概率随着发射数目的增加而显著增加;当导弹发射数目超过6枚时,目标毁伤概率高达95.3%以上,基本达到饱和;导弹I₂作战效能明显比导弹I₁高；当发射导弹数量小于等于3枚时, I₂的体系相对贡献率达到133.3%以上。     

圆周上的贝塞尔级数的等价收敛定理

定义了单位圆周上的贝塞尔级数;给出其核函数的渐近表示;讨论与其相应的幂级数间的等价收敛定理及其应用．