灵芝抗纤毛虫细胞衰老机理的初探

本文检测了用灵芝处理棘尾虫和草履虫衰老细胞后的效果,发现灵芝的制剂和浸液可衰老棘尾虫在核ＤＮＡ含量消减速度减慢核仁膨胀程度降低;还发现灵芝浸液能增强衰老棘尾虫和草履虫消除自由基的能力。     

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p53 (ref. 1). Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the tumor-suppressor functions of p53 and the ASPP proteins. Here, we characterize such a protein, iASPP (inhibitory member of the ASPP family), encoded by PPP1R13L in humans and ape-1 in Caenorhabditis elegans. iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis. Moreover, iASPP is an oncoprotein that cooperates with Ras, E1A and E7, but not mutant p53, to transform cells in vitro. Increased expression of iASPP also confers resistance to ultraviolet radiation and to cisplatin-induced apoptosis. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53 and normal levels of ASPP. Inhibition of iASPP could provide an important new strategy for treating tumors expressing wild-type p53.     

四川省城市社区居民体育需求服务体系的构建

运用文献资料法、问卷调查法、实地访谈法、数理统计法和逻辑分析法等研究方法,在充分了解四川省城市社区居民体育活动状况的基础上构建了城市社区居民体育需求服务体系,研究表明:城市社区居民的体育需求并非单纯的体育消费需求,还包括从事体育活动的基本条件需求、体育资信的需求、体育归属的需求、体育环境的需求和体育指导的需求等;针对此多种需求提出了发展城市社区体育的相关策略.     

关联于资产价格波动的货币政策非对称性检验——基于修正NK-SVAR模型的实证分析

资产价格波动通过多种途径影响宏观总产出,进而间接反映在货币调控的效应测度上.基于此,本文针对新凯恩斯模型进行了修正,在货币政策非对称效应的SVAR模型检验中导入了资产价格变化和汇率波动的影响.实证结果表明,紧缩货币政策较扩张性政策具有更强的产出冲击,但其效应显著关联于资产价格变化,这就要求资产价格变化必须纳入到未来相机抉择的货币政策体系中.     

关于会计模拟实训创新的探讨

由于学生的会计专业技能是未来工作的需要,会计模拟实训教学成为全国各大高校较关注的问题,各个高校都采用了实践教学手段,期望培养出企业所需要的、具有较强动手能力的会计专业人才。本文根据会计模拟实训的目标,就会计模拟实训创新问题提出了自己的观点。     

基于摄像头的直立行走智能车控制系统设计

针对以往靠中心线提取速度较慢导致车模方向控制不稳,容易跑出赛道等问题,设计以K60微控制器为核心控制单元,利用CMOS摄像头对路径信息进行采集,在提取赛道边界和控制车体方向时创新性的使用了"窗口检测法"和"双比例"PD控制方法。"窗口检测法"能够缩短赛道边界的提取时间,提高搜索效率。双比例PD控制能够对比例参数P进行实时调整,进而更及时、准确地控制车模的运行方向。     

分数跳-扩散环境下欧式双向期权定价的Ornstein-Uhlenbeck模型

假定标的资产价格服从由分数布朗运动和复合泊松过程共同驱动的随机微分方程,建立分数跳-扩散Ornstein-Uhlenbeck模型.利用公平保费原则和保险精算方法,得到了欧式双向期权的定价公式.     

Batching Scheduling in a Two-Level Supply Chain with Earliness and Tardiness Penalties

This paper studies the batch sizing scheduling problem with earliness and tardiness penalties which is closely related to a two-level supply chain problem. In the problem, there are K customer orders, where each customer order consisting of some unit length jobs has a due date. The jobs are processed in a common machine and then delivered to their customers in batches, where the size of each batch has upper and lower bounds and each batch may incur a fixed setup cost which can also be considered a fixed delivery cost. The goal is to find a schedule which minimizes the sum of the earliness and tardiness costs and the setup costs incurred by creating a new batch. The authors first present some structural properties of the optimal schedules for single-order problem with an additional assumption (a): The jobs are consecutively processed from time zero. Based on these properties, the authors give a polynomial-time algorithm for single-order problem with Assumption (a). Then the authors give dynamic programming algorithms for some special cases of multiple-order problem with Assumption (a). At last, the authors present some structural properties of the optimal schedules for single-order problem without Assumption (a) and give a polynomial-time algorithm for it.     

车辆动力换挡与换挡品质控制分析

阐述了车辆动力换挡的概念及换挡品质的控制方法,分析了车辆动力换挡的过程,同时对典型车辆传动装置换挡品质控制原理进行了较为深入的分析。     

浙江省县市综合经济实力分析

利用浙江省2005年有关统计数据,分别采用加权平均法、主成分分析法、因子分析法和聚类分析法对浙江省58个县级市、县的综合经济实力进行了综合评价和排位.其方法科学、合理.对于帮助各地区看到自己所处的位置,明确自己的经济实力提供了一个度量准则.