四川盆地北部二叠系茅口组沉积特征及油气意义

基于地震资料精细解释成果,结合野外剖面及室内薄片观察,通过分析主要岩石类型及古生物、地球化学和地震相特征,对四川盆地北部二叠系茅口组沉积相展布特征进行研究,依据生物(屑)灰岩、礁灰岩和硅质岩等岩相发育规律以及地震地层结构和地层厚度变化特征,认为茅口组发育了开阔台地、台地边缘及斜坡—盆地等沉积亚相,总结出了开阔海夹点礁、开阔海夹点滩、台地边缘滩和灰质—硅质盆地等4种沉积微相组合,明确了沉积相纵向演化和平面展布规律。结果表明,台地边缘高能生物滩平面上呈条带状在剑阁—元坝—龙岗一带规模发育,生物(屑)灰岩的晶间溶孔、粒间溶孔和生物体腔孔发育,物性好,是优质储集层发育带;川西海槽和广元—旺苍海槽茅四段的硅质岩和泥岩有机碳含量高,则是优质生油岩,优越的沉积环境为该区油气成藏提供了有利的生油和储集条件。     

低能小型医用回旋加速器谐振腔的有限元分析

应用有限元方法分析了一台小型医用回旋加速器的谐振腔.以PC机为平台,采用ANSYS软件进行建模,对腔体的谐振频率、空载品质因数进行了研究,探讨了微调电容间距、网格剖分精度以及建模方法对计算结果的影响.回旋加速器谐振腔不是一个严格的封闭腔体,结构复杂.为减少计算量,根据其物理特性对腔体做了封闭处理,研究发现,这一简化的模型对计算精度的影响不大.计算结果和实际测量结果的误差在工程允许的范围之内,表明基于有限元的软件能够很好地计算类似回旋加速器高频谐振腔这样具有复杂边界的腔体结构,可用于加速器的物理设计及工程设计.     

地铁工程中高性能混凝土耐久性综合评估

针对南京地铁主体工程C30泵送混凝土,从设计强度、工作性、经济性、抗裂防渗性能及耐久性能等4个方面制定了混凝土性能综合评定指标;通过各试验配比混凝土性能检测结果,对南京地铁主体工程C30高性能泵送混凝土进行了综合评估,并推荐工程施工配合比为双掺粉煤灰加矿渣微粉混凝土,活性掺合料掺量为46%~56%,粉煤灰占活性掺合料总量的比例为34%~50%;或为单掺粉煤灰混凝土,粉煤灰掺量为25%~30%,保证了南京地铁工程钢筋混凝土100年耐久性目标的实现.     

1546例泌尿生殖道支原体感染及药敏分析

目的:了解近年广州市性病门诊患者支原体感染及耐药情况,为临床选择敏感治疗药物提供参考依据。方法:对1 546例性病门诊患者进行了支原体培养,并对阳性标本进行10种抗生素药敏试验。采用支原体培养、鉴定及药敏一体化试剂盒进行检测。结果:1 546例中支原体阳性560例,阳性率为36.22%。解脲脲原体(Uu)、人型支原体(Mh)及Uu Mh混合感染的阳性率分别为28.85%、1.03%、6.34%。Uu感染敏感率最高的是交沙霉素(92.4%),其次是强力霉素(85.7%)、美满霉素(80.9%);耐药率最高的为环丙沙星(69.5%),其次是罗红霉素(63.3%)、阿奇霉素(61.2%)。Mh感染敏感率最高的是强力霉素(68.8%)、美满霉素(62.5%);耐药率最高的为环丙沙星、氧氟沙星、阿奇霉素、克拉霉素(均为50.0%)。Uu Mh混合感染敏感率最高的是强力霉素(39.8%)、美满霉素(35.7%);耐药率最高的为环丙沙星和罗红霉素(均为63.3%)、阿奇霉素(61.2%)。结论:性病门诊支原体感染主要为Uu引起;就广州市支原体感染而言,应将交沙霉素、强力霉素或美满霉素作为目前治疗泌尿生殖道支原体感染的首选抗生素。     

The Differentiated Effect of Administrative Policy in China's Housing Market——Based on the Heterogeneous Households Multi-Agent Model

Since 2010, Chinese government has introduced a series of administrative policies to limit speculation in the housing market to stabilize price fluctuations and keep the housing market in a healthy state of development. In order to investigate whether administrative policy can play its due role, this paper constructs a comprehensive bottom-up housing market heterogeneous households multiagent model(HHMAM) to undertake research on the differentiated effect of administrative policy in different cities. The empirical studies find that: 1) Administrative policy that increases interest rates will cause housing prices to continue to decline in the long term, but they will resume a rising trend after reaching the lowest point; 2) If the government cancels a property-purchasing limitation, housing prices will continue to rise; and 3) investors tend to invest in 1~(st)-tier cities due to the high demand and greater likelihood of appreciation in these cities.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

考虑自动驾驶仪动态特性与攻击角约束的模糊自适应动态面末制导律

在大口径舰炮制导炮弹打击近岸机动目标的末制导段,考虑自动驾驶仪二阶动态特性与攻击角约束,基于模糊自适应逼近与动态面控制提出一种末制导律。构建二维弹目相对运动模型,运用扩张状态观测器估计目标加速度。为零化视线角的跟踪误差与视线角速率,采用自适应指数趋近律设计非奇异终端动态面滑模,设计模糊自适应系统逼近变结构项,削弱自动驾驶仪的控制指令抖振。通过Lyapunov第二法证明了闭环系统中视线角的跟踪误差与视线角速率均一致最终有界。仿真实验表明:该制导律使制导炮弹在打击具有不同加速度形式的目标时,均具备较好的末制导性能。     

窖水中主要无机离子对光催化灭除大肠杆菌(E.coli)的影响研究

采用自主开发的N-TiO_2作为光催化剂,在流动相光催化反应装置中,对窖水中所含Ca~(2+)、Cl~-、CO_3~(2-)、HCO_3~-、SO_4~(2-)等主要无机离子对光催化剂灭除E.coli的影响,以及复配模拟窖水和实际窖水对光催化灭除E.coli的影响进行了实验研究,并分析了其影响机理。实验结果表明:Ca~(2+)、HCO_3~-对光催化灭除E.coli有抑制作用,CO_3~(2-)对光催化灭除E.coli有明显的促进作用,而SO_4~(2-)、Cl~-对光催化灭除E.coli无影响。在对实际窖水进行光催化灭除E.coli菌落总数的实验中,经60min反应,窖水中菌落总数和总大肠菌群均为零,达到国家饮用水卫生标准,说明自主开发的NTiO_2光催化剂在农村窖水深度处理灭除E.coli效果好,可推广应用。     

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

Toll-like receptors (TLRs) act as sensors of microbial components and elicit innate immune responses. All TLR signaling pathways activate the nuclear factor-kappaB (NF-κB), which controls the expression of inflammatory cytokine genes. Transforming growth factor-β-activated kinase 1 (TAK1) is a serine/threonine protein kinase that is critically involved in the activation of NF-κB by tumor necrosis factor (TNFα), interleukin-1β (IL-1β) and TLR ligands. In this study, we identified a novel protein, WD40 domain repeat protein 34 (WDR34) as a TAK1-interacting protein in yeast two-hybrid screens. WDR34 interacted with TAK1, TAK1-binding protein 2 (TAB2), TAK1-binding protein 3 (TAB3) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in overexpression and under physiological conditions. Overexpression of WDR34 inhibited IL-1β-, polyI:C- and lipopolysaccharide (LPS)-induced but not TNFα-induced NF-κB activation, whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-κB activation by these ligands. Our findings suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway. D. Gao and R. Wang contributed equally to this work.