过滤器的安全模型框架

采用Ｂｅｌｌ－ＬａＰａｄｕｌａ（ＢＬＰ）模型的风格及其表述方法，讨论了信息过滤器一类系统的安全模型框架。提出的过滤器模型框架扩充了ＢＬＰ模型的适用范围。结果表明，ＢＬＰ模型不仅适用于操作系统的建模，而且还适用于其它的一类系统建模。     

高阶抽象Cauchy问题的解析性与指数稳定性

研究高阶抽象Ｃａｕｃｈｙ问题的解及其传播算子的解析性与指数稳定性，得到一些基本结果。同时给出了所得结果对抛物方程的混合问题的应用例子。     

高速铁路车辆轴承试验机微机监控与诊断系统

介绍了所研制的高速铁路车辆轴承试验机微机监控与诊断系统；重点讨论了工况监视与诊断的实现技术；并把该系统成功地应用于高速铁路车辆轴承的模拟试验中．     

全混洗光互连的矩阵处理与研究

引入矩阵的方法分析处理全混洗互连变换，用矩阵方程形式直观地表达了一些已知的，以及一些新的全混洗互连性质，并阐明了其物理意义，同时提出了全混洗互连、逆全混洗互连的光学实现方法。     

新型高效冷风机翅片管紧固效果的试验研究

采用网格法测量了冷风机翅片冲压加工的变形量，确定了翅片材料的成形极限。用塑性大应变计测试了不同工况下冷风机翅片管胀管变形的全过程，建立了分析冷风机翅片管紧固效果的特征曲线方法，提出了用宽裕度作为胀头过盈量设计取值的概念，综合评价了不同翅片管的紧固效果。     

自动选择重发方案的改进

在自动请求重发（ＡＲＱ）方案中，选择重发（ＳＲ）比等待重发（ＳＷ）和重返Ｎ－ＧＢＮ具有更高的传输效率，该效率是信道误码率、帧长及往返延时的函数。在任一给定的误码率情况下，可求得一种最佳帧长使传输效率达到最高。     

Uptake of3H-noradrenaline and3H-5-hydroxytryptamine in cultured rat brainstem

Zusammenfassung Die zelluläre Lokalisation der Aufnahme von³H-NA und³H-5HT in den Hirnstamm von Ratten wurde am Modell der Nervengewebskultur untersucht. Im Gegensatz zu den Aminosäure-Transmittern, welche in Neurone und Gliazellen aufgenommen werden, zeigen Monoamine nur eine Aufnahme in Zellkörper und Fortsätze von Neuronen, nicht jedoch in Gliazellen. Es besteht eine Korrelation zwischen den Ergebnissen von fluoreszenzmikroskopischen Versuchen und unseren autoradiographischen Untersuchungen.     

Free energy perturbation calculations on binding and catalysis after mutating Asn 155 in subtilisin

Site-directed mutagenesis is a very powerful approach to altering the biological functions of proteins, the structural stability of proteins and the interactions of proteins with other molecules. Several experimental studies in recent years have been directed at estimating the changes in catalytic properties, (rates of binding and catalysis) in site-directed mutants of enzymes compared to the native enzymes. Simulation approaches to the study of complex molecules have also become more powerful, in no small measure owing to the increase in computer power. These simulations have often allowed results of experiments to be rationalized and understood mechanistically. A new approach called the free-energy pertubation method, which uses statistical mechanics and molecular dynamics can often be used for quantitative calculation of free energy differences. We have applied such a technique to calculate the differential free energy of binding and free energy of activation for catalysis of a tripeptide substrate by native subtilisin and a subtilisin mutant (Asn 155----Ala 155). Our studies lead to a calculated difference in free energy of binding which is relatively small, but a calculated change in free energy of catalysis which is substantial. These energies are very close to those determined experimentally (J. A. Wells and D. A. Estell, personal communication), which were not known to us until the simulations were completed. This demonstrates the predictive power and utility of theoretical simulation methods in studies of the effects of site-specific mutagenesis on both enzyme binding and catalysis.