Soluble proteins in insect chemical communication

Our understanding of the biochemical mechanisms that mediate chemoreception in insects has been greatly improved after the discovery of olfactory and taste receptor proteins. However, the presence of soluble polypeptides in high concentration around the dendrites of sensory neurons still poses unanswered questions. More than 2 decades after their discovery and despite the wealth of structural information available, the physiological function of odorant-binding proteins is not well understood. More recently, members of a second family of soluble polypeptides, the chemosensory proteins, were also discovered in the lymph of chemosensilla. Here we review the structural properties of both classes of soluble proteins, their affinity to small ligands, and their expression in the different parts of the insect body and subcellular localisation. Finally, we discuss current ideas and models of the role of such proteins in insect chemoreception. Received 27 December 2005; received after revision 6 March 2006; accepted 13 April 2006     

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major histocompatibility complex on chromosome 6p. We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets (overall P = 2.9 x 10(-7)). Further, the likely causal SNP, rs6897932, located within the alternatively spliced exon 6 of IL7R, has a functional effect on gene expression. The SNP influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer.     

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.     

粤北地区体育旅游资源开发研究

粤北地区丰富的自然资源和人文资源优势蕴含着巨大的旅游发展潜力，但其体育旅游开发存在着经济基础差、体育设施少、人才缺乏和赛事组织经验不足等不利因素，针对这些问题提出了相应解决问题的策略与建议。     

Boron-based Drug Design for Cancer Therapy

1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) protein tyrosine kinase is one of the important kinases that play a fundamental role in cell growth signal pathways.We focused on the 4-anilinoquinazoline framework,which is observed in both compounds as a common structure.A boron atom has a vacant orbital and interconverts with ease between th...     

随机弹性及在库存管理中的应用

经济运行带有不确定性和随机性，这些不确定性和随机性因素是造成决策者不能做出正确决策的原因之一．利用随机弹性概念。研究了不允许缺货的整批间隔进货模型和不允许缺货的分批连续进货模型中，一个采购周期内的总费用对最高库存量的弹性．给出了总费用弹性概率密度的一般表达式．通过实例证明了当最高库存量的分布特性已知时。总费用的弹性变化范围及变化范围的可信度．     

半刚性桩复合地基几个问题的探讨

文章对水泥土桩的变形模量、水泥土桩及CFG桩的桩间土应力发挥系数β，进行了试验研究及理论分析。     

通用虚拟现实软件开发平台的研究及其应用

针对快速构建虚拟现实应用系统的需要，开发出全集成化，功能完备且性能先进的通用虚拟现实软件开发平台VRMagic。该平台采用模块化设计，模块之间通过统一的数据结构相互通讯。基于WTK的三维虚拟演播室子系统是该平台的核心模块，它通过解析仿真描述文件产生虚拟场景，具有六自由度漫游、实时交互，实时视频合成与GIF动画等功能，同时支持立体眼镜、V8头盔、CyberGlove数据手套与多种定位与跟踪设备。通过将生物大分干三维结构信息转化为仿真描速文件，可利用访平台实现生物大分于三维空间结构及其动态演化过程的虚拟现实显示。     

树对人乙型肝炎病毒易感性的验证

为验证树对人乙型肝炎病毒 (HBV)的易感性 ,用含 HBV的人血清接种给 10只成年树 (雌雄各半 )。然后每周抽血 1次 ,每只动物共抽血 11次。用不同公司生产的 EL ISA试剂检测接种后的动物血清感染指标。实验观察至 13周 ,结果分别有 9只和 7只动物出现 HBs Ag阳性 ,持续最短 1周 ,最长 7周。用 PCR检测 ,结果有 1只动物连续 4周在血清中检测出 HBV DNA。表明树能感染人 HBV,但实验有待改进以延长感染持续时间