认知无线网络自适应功率控制博弈算法

为满足认知无线网络环境下各认知用户的需求,综合考虑认知用户距离基站的远近、算法稳定性及用户间的干扰问题,使用非合作博弈论对认知无线网络中的功率控制问题进行建模,提出一种使用收益函数和综合代价函数共同表示效用的自适应功率控制算法,理论证明了该算法存在唯一的纳什均衡解。通过引入综合代价函数,使各认知用户在非合作博弈下包含了协作的行为,从而获得帕累托最优解。Matlab仿真表明,该自适应功率控制算法在满足不同用户对SIR需求不同的前提下,克服了远近效应,降低了认知用户的发射功率,实现了高频效和频谱共享的公平性。     

面向智慧物联网的新型嵌入式仿真技术研究

当前我们正步入新时代、正面临新态势、正迈进新征程,人类社会国民经济、国计民生和国家安全等各领域系统的模式、技术和业态正在向数字化、网络化、云化、智能化的"智慧物联网"新模式、新技术和新业态发生重大变革.智慧物联网的发展迫切需要面向智慧物联网的新型嵌入式仿真技术,使智慧物联网能具备在线、持续的分析、认知、学习、决策、运行...     

用Poincar截面研究近金属表面里德堡氢原子的动力学性质

用相空间分析方法研究了近金属表面氢里德堡原子的动力学性质.从Poincar啨截面看出,其动力学行为敏感地依赖于原子与金属表面间的距离d,随着d值的增减,系统的可积性会发生巨大改变.     

可调叠片式径向剃齿刀的研制

本文概述了径向剃齿刀的特点及其制造中的问题,设计了叠片斜装式径向剃齿刀。应用单自由度啮合原理计算出剃齿刀的理论廓形及与其共轭的砂轮廓形,利用锥面逼近砂轮共轭面,发展了用锥面砂轮刃磨径向剃齿刀的新工艺。     

Study on structure-activity relationship of mutation-dependent herbicide resistance acetohydroxyacid synthase through 3D-QSAR and mutation

Seventy-four sulfonylureas were synthesized and tested for their inhibitory activity against the whole enzyme of E. coli acetohydroxyacid synthase (AHAS, EC 2.2.1.6) isoenzyme II, and 3D-QSAR analyses were performed based on these inhibitory activities. The binding conformation of chlorimuron-ethyl, a commercial herbicide of AHAS, in the crystal structure of AHAS complex was extracted and used as template to build the initial three-dimensional structure of other sulfonylureas, and then all structures were fully geometry optimized. After systematic optimization of the alignment rule, molecular orienta- tion, grid space and attenuation factor, two satisfactory models with excellent performances (CoMFA: q2 = 0.735, r2 = 0.954, n = 7, r 2 pred = 0.832; CoMSIA: q2 = 0.721, r2 = 0.913, n = 8, r 2pred = 0.844) were estab- lished. By mapping the 3D contour maps of CoMFA and CoMSIA models into the possible inhibitory active site in the crystal structure of catalytic subunit of yeast AHAS, a plausible binding model for AHAS, with best fit QSAR in the literature so far, was proposed. Moreover, the results of 3D-QSAR were further utilized to interpret resistance of site-directed mutants. A relative activity index (RAI) for AHAS enzyme mutant was defined for the first time to relate the 3D-QSAR and resistance of mutants. This study, for the first time, demonstrated that combination of 3D-QSAR and enzyme mutation can be used to decipher the molecular basis of ligand-receptor interaction mechanism. This study refined our understanding of the ligand-receptor interaction and resistance mechanism in AHAS-sulfonylurea system, and provided basis for designing new potent herbicides to combat the herbicide resistance.     

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major histocompatibility complex on chromosome 6p. We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets (overall P = 2.9 x 10(-7)). Further, the likely causal SNP, rs6897932, located within the alternatively spliced exon 6 of IL7R, has a functional effect on gene expression. The SNP influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer.     

改进DDET的分支生成机制——设备失效概率阈值法

概率阈值法是离散动态事件树(dynamic discrete event tree,DDET)常用的分支生成方法,此方法存在没有考虑实际设备失效的问题,建立的DDET具有较大不确定性,本文针对概率阈值法存在的不足提出相应的改进措施——设备失效概率阈值法.通过动态水箱实例分析发现,设备失效概率阈值法的总节点数仅是概率阈值法50%左右,计算时间节省了近70%,说明设备失效概率阈值法具有重要的工程应用价值;设备失效概率阈值法得到的总事故概率比概率阈值法的保守一些,及其建立的DDET更能贴近动态水箱的真实情况来反应系统的运行动态特性,利于研究动态水箱更为真实的事故演化过程.     

Boron-based Drug Design for Cancer Therapy

1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) protein tyrosine kinase is one of the important kinases that play a fundamental role in cell growth signal pathways.We focused on the 4-anilinoquinazoline framework,which is observed in both compounds as a common structure.A boron atom has a vacant orbital and interconverts with ease between th...