Platelet-derived growth factor receptor-β in myocyte was upregulated by angiotensin Ⅱ

To observe the regulation of platelet-derived growth factor (PDGF) receptor-βin myocyte stimulated by angiotensin II (AngII) at both integrated and cellular levels and reveal the signal transduction mechanism in cell, two kidneys, one clip (2K1C) renal hypertension were performed by placing a sliver clip around the left renal artery. Blood pressure and the ratio of left ventricular weight to body weight were measured at 4 and 8 weeks after operation. The content of AngII in heart was detected by radioimmunology assay; the protein level of PDGF receptor-βin heart was measured by Western blot analysis. The alteration of PDGF receptor-βstimulated by AngII and several inhibitors was observed on cultured neonatal rat ventricular myocyte (NRVM). The content of AngII in heart of 2K1C renal hypertensive rat at 4 and 8 weeks after operation was increased. Compared with sham group, 4 and 8 weeks after operation, PDGF receptor-βin heart of 2K1C group was upregulated by 100.3% and 127.1% (P < 0.05), respectively. This upregulation could be inhibited by captopril. For cultured myocyte, PDGF receptor-βwas increased by 47.1% after being stimulated by AngII and this upregulation could be inhibited by losartan which was an inhibitor of AT1 receptor. PLC inhibitor (U73122) and MEK inhibitor (PD98059) could partly inhibit PDGF receptor-βupregulation induced by AngII. These results suggested that AngII could upregulate PDGF receptor-βin myocyte by its AT1 receptor and this effect was at least partly dependent on PLC and extracellular signal-regulated kinase (ERK).     

Control dynamics of severe acute respiratory syndrome transmission

Severe acute respiratory syndrome (SARS) is a serious disease with many puzzling features. We present a simple, dynamic model to assess the epidemic potential of SARS and the effectiveness of control measures. With this model, we analysed the SARS epidemic data in Beijing.The data fitting gives the basic case reproduction number of 2.16 leading to the outbreak, and the variation of the effective reproduction number reflecting the control effect. Noticeably, our study shows that the response time and the strength of control measures have significant effects on the scale of the outbreak and the lasting time of the epidemic.     

时域有限差分法对H-型微带天线的数值计算

时域有限差分法是一种目前已广泛应用于电磁场与微波工程中的时域数值计算方法。H型的微带贴片天线利用时域有限差分法，采用廖氏三阶吸收边界来对无限安全空间进行有限截断。与普通的矩形贴片天线相比，该天线具有更小的体积，从而更易与其它物体（如车辆、电视机、笔记本电脑等）集成。基于大量的数值计算结果，给出了该天线的谐振频率图随天线各主要设计参数的变化曲线，及辐射方向图随天线参数的变化情况，并对理论计算结果与已有一些实验数据进行了比较，符合较好，验证了本理论计算的可靠性。     

D+CH4→CH3+HD反应的量子含时动力学研究

运用SVRT(semirigidvibratingrotortarget)模型[1 ] ,对反应D CH4 →CH3 HD进行了量子含时动力学研究 .计算结果表明 ,反应几率随平动能的变化曲线 ,呈现出显著的量子共振特性 .H -CH3的振动激发 ,极大地提高了反应几率 ,转动量子数j的增大 ,也会使反应几率有较大的提高 .结果表明 ,SVRT模型对于精确计算某些多原子分子间的反应碰撞 ,是十分有效的     

雾灵山植被变化遥感监测

雾灵山国家级自然保护区位于北京市密云县与河北省兴隆县交界处 ,是潮白河与滦河水系的分水岭 ,也是两水系部分支流的源头。近些年来由于山区旅游无序开发 ,对植被造成一定程度的破坏 ,对环境造成一定影响。本文通过遥感技术 ,利用 1 984年TM和 2 0 0 2年ETM数据对植被变化状况进行了监测 ,并提出一些建议和对策     

黄河下游湿地芦苇种群克隆结构的等位酶分析

以等位酶为标记，采用水平切片淀粉凝胶电泳技术，对黄河下游湿地15个芦苇(Phragmites australis (Cav.) Trin.ex Steud)群的克隆结构进行了初步研究．8个酶系统17个等位酶位点的检测表明，芦苇种群克隆多样性很高，基因型比率PD=0．53(0．10—0．85)，不同克隆在规模上相差很大．克隆结构分析表明，芦苇种群内克隆之间的镶嵌明显．     

流程工业的信息集成系统

流程工业由于其生产过程的特殊性,其CIMS与离散工业有较大的区别,有其特殊的方面.本文主要讨论了流程工业CIMS的特点及其整体框架,以及流程工业信息集成系统设计时所须注意的要点,最后讨论了流程CIMS的关键技术.     

中国高等院校校办产业情况分析

用大量真实的数字和图表，阐明中国高等院校校办产业的实际状况，说明中国高校开发和发展产业的意义与作用，诠释中国高校产业与教学科研的相互促进关系，指出中国高校产业存在的问题，提出解决问题的建议和意见。     

低压铸造温度场数值模拟中换热情况处理

以戴卡轮毂制造有限公司铝合金轮毂生产为背景，开发以个人微机为硬件基础的Windows平台下低压铸造充型与凝固模拟软件。传热计算是凝固模拟技术的基础，对低压铸造复杂的边界换热现象进行了全面的研究，建立了引入冷却介质模型块的立体计算模型，根据传热计算中的节点分布位置，详细分析了各种不同的传热计算方式，并针对实际生产中用户可以直接调控的冷却系统参数建立了综合的计算模型。     

能耗自动监测系统

针对中小炼油厂具体情况，为降低生产成本，提高经济效益，在调度中心使用一台研华工业控制机为上位机，下位机采用日本松下FP3可编程控制器，构成了分布式的监测系统。经过实际运行表明，该系统性能稳定、功能强大，各项技术指标均达到设计要求。