基于L-M算法的EV71传播预测模型

本文基于神经网络L-M优化算法,提出一种时EV71病毒的有效预测模型,利用matlab进行仿真模拟,结果和阜阳病毒感染情况非常符合.神经网络L-M优化算法克服了神经网络BP算法收敛速度慢的缺点,同时通过学习训练,本模型的神经系统具有有效性和通用性的特点.     

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.     

Control of a key transition from prostrate to erect growth in rice domestication

The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication.     

最优资金流施工进度计划的风险分析

本文以合成事件技术为基础,研究进度计划中非关键路径对于关键路的时间干扰问题,定义了安全使用时差的新概念,以便对松驰时间和资金最佳运用情况作出可靠的风险决策。     

航空电子综合化数据传输网络建模方法研究

采用Petri网理论对航空电子综合化数据传输网络系统的建模方法进行研究。通过对研究对象的基本假设、研究对象与Petri网理论之间的关系,给出了航空电子综合化数据传输网络系统的Petri网模型     

模型误差与轨道精度

应用模型与实际模型总是存在差异,如何从理论上探讨这种差异的影响以及在实际处理中如何进行选择是非常困难的。本文中分析了差异的主要原因,明确了模型误差的概念,并从理论上探讨了模型误差对轨道估计精度的影响,给出了具体的影响误差计算公式;在此基础上,提出了轨道参数的估计效率和客户效率的概念,并由此导出了模型误差处理原则,从而回答了实际数据处理中,模型误差处理方案的选择问题。最后,给出了一个应用实例     

通过课堂观察探究独立学院英语课堂中的互动模式

文章通过定性研究的方法,以作者工作的独立学院的非英语专业学生为研究对象,对英语课堂中的互动教学模式进行探讨.首先,作者通过访谈,了解适合独立学院学生的英语课堂互动模式;其次,结合教师的观察日志和学生的日记反馈、分析他们在各种英语课堂互动模式中的表现,以便在独立学院英语教学中准确恰当地运用课堂互动模式,激发学生的学习动机、端正学生的学习态度,提高学生的语言综合应用能力.     

Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus

We have recently described two kindreds presenting thoracic aortic aneurysm and/or aortic dissection (TAAD) and patent ductus arteriosus (PDA) and mapped the disease locus to 16p12.2-p13.13 (ref. 3). We now demonstrate that the disease is caused by mutations in the MYH11 gene affecting the C-terminal coiled-coil region of the smooth muscle myosin heavy chain, a specific contractile protein of smooth muscle cells (SMC). All individuals bearing the heterozygous mutations, even if asymptomatic, showed marked aortic stiffness. Examination of pathological aortas showed large areas of medial degeneration with very low SMC content. Abnormal immunological recognition of SM-MHC and the colocalization of wild-type and mutant rod proteins in SMC, in conjunction with differences in their coimmunoprecipitation capacities, strongly suggest a dominant-negative effect. Human MYH11 gene mutations provide the first example of a direct change in a specific SMC protein leading to an inherited arterial disease.