中央空调噪声分析及控制研究 3

中央空调机组的噪声源主要来自于气动、机械和电磁等3个方面因素,并以此提出了中央空调机组噪声控制方法;从3个方面系统地分析和论述了噪声控制措施:选择包括高阻尼减振垫、叶片数量多的轴流风叶等性能良好的动力部件,利用金属网罩等特殊结构的隔音减振结构设计,采用合理的安装工艺并利用消声装置等机组合理的安装和配置等;实践表明,此方法较好地控制了中央空调的运行噪声.     

随机微分方程的非参数估计 及其在股票指数中的应用 3

建立了股票指数的随机微分方程模型,采用非参数估计方法对其进行估计,并给出了相应的非参数估计表达式,接着给出了具体的非参数估计算法,最后利用上证指数的收盘价数据进行实证分析,实证表明该模型能较好的刻画股票指数的许多统计特征,非参数估计方法也切实有效,模拟效果较好,能较好的预测股票指数的未来趋势。     

浅谈重庆地区高速公路的绿化设计

对重庆地区高速公路的绿化现状进行了分析,提出了重庆地区所有在建和已建高速公路的绿化设计原则,针对重庆地区特有的地域文化进行绿化布置与树种搭配,并简述了重庆地区高速公路绿化设计的细节.     

Crystal structure of a rhomboid family intramembrane protease

Escherichia coli GlpG is an integral membrane protein that belongs to the widespread rhomboid protease family. Rhomboid proteases, like site-2 protease (S2P) and gamma-secretase, are unique in that they cleave the transmembrane domain of other membrane proteins. Here we describe the 2.1 A resolution crystal structure of the GlpG core domain. This structure contains six transmembrane segments. Residues previously shown to be involved in catalysis, including a Ser-His dyad, and several water molecules are found at the protein interior at a depth below the membrane surface. This putative active site is accessible by substrate through a large 'V-shaped' opening that faces laterally towards the lipid, but is blocked by a half-submerged loop structure. These observations indicate that, in intramembrane proteolysis, the scission of peptide bonds takes place within the hydrophobic environment of the membrane bilayer. The crystal structure also suggests a gating mechanism for GlpG that controls substrate access to its hydrophilic active site.     

洛阳智慧交通系统的地址匹配技术

根据洛阳市城市道路分布的实际情况,研究洛阳智慧交通系统的道路动态段技术、地址数据库结构和数据追加方法、地址数据库和道路数据库的匹配策略.     

用系统观看待农业高新技术改造传统农业

基于系统论的观点,分析农业高新技术系统的内涵、特征、结构和功能,以及可持续运行的条件,阐述高新技术改造传统农业的实质。要完成农业高新技术对传统农业的改造,必须加大政府对我国农业科技的投资力度、进行科技运行体制改革、采取合适的模式让农业高新技术走进农家和因地制宜采取合适的农业高新技术。     

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain

Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of proteins within the hydrophobic bilayer, and how this could affect protein function. Here we show a direct and highly specific interaction of exclusively one sphingomyelin species, SM 18, with the TMD of the COPI machinery protein p24 (ref. 2). Strikingly, the interaction depends on both the headgroup and the backbone of the sphingolipid, and on a signature sequence (VXXTLXXIY) within the TMD. Molecular dynamics simulations show a close interaction of SM 18 with the TMD. We suggest a role of SM 18 in regulating the equilibrium between an inactive monomeric and an active oligomeric state of the p24 protein, which in turn regulates COPI-dependent transport. Bioinformatic analyses predict that the signature sequence represents a conserved sphingolipid-binding cavity in a variety of mammalian membrane proteins. Thus, in addition to a function as second messengers, sphingolipids can act as cofactors to regulate the function of transmembrane proteins. Our discovery of an unprecedented specificity of interaction of a TMD with an individual sphingolipid species adds to our understanding of why biological membranes are assembled from such a large variety of different lipids.     

How atomic nuclei cluster

Nucleonic matter displays a quantum-liquid structure, but in some cases finite nuclei behave like molecules composed of clusters of protons and neutrons. Clustering is a recurrent feature in light nuclei, from beryllium to nickel. Cluster structures are typically observed as excited states close to the corresponding decay threshold; the origin of this phenomenon lies in the effective nuclear interaction, but the detailed mechanism of clustering in nuclei has not yet been fully understood. Here we use the theoretical framework of energy-density functionals, encompassing both cluster and quantum liquid-drop aspects of nuclei, to show that conditions for cluster formation can in part be traced back to the depth of the confining nuclear potential. For the illustrative example of neon-20, we show that the depth of the potential determines the energy spacings between single-nucleon orbitals in deformed nuclei, the localization of the corresponding wavefunctions and, therefore, the degree of nucleonic density clustering. Relativistic functionals, in particular, are characterized by deep single-nucleon potentials. When compared to non-relativistic functionals that yield similar ground-state properties (binding energy, deformation, radii), they predict the occurrence of much more pronounced cluster structures. More generally, clustering is considered as a transitional phenomenon between crystalline and quantum-liquid phases of fermionic systems.     

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality control in 227 samples from Africa, Asia and Oceania provides genome-wide estimates of allele frequency distribution, population structure and linkage disequilibrium. By comparing the genetic diversity of individual infections with that of the local parasite population, we derive a metric of within-host diversity that is related to the level of inbreeding in the population. An open-access web application has been established for the exploration of regional differences in allele frequency and of highly differentiated loci in the P.?falciparum genome.