Changes in activity of rat epididymal adipose tissuein vitro due to time elapsed since last feeding

Résumé Les auteurs ont verifié l'influence du temps écoulé depuis le dernier repas sur la sensibilité de la graisse de l'épididyme du rat à l'insulinein vitro, en utilisant la méthode manométrique. Des groupes d'animaux ont été alimentés 24, 5 et 2 1/2 h avant d'être sacrifiés. Le délai de 5 h semble être préférable parce qu'il offre la meilleure base et des résultats plus constants.     

离子束增强沉积纳米Fe—N磁性膜

利用高能量（〉１５ｋｅＶ）、脉冲氮离子束增强沉积（ＩＢＥＤ）Ｆｅ－Ｎ磁性薄膜。合成了含有α－Ｆｅ、α″－Ｆｅ１６Ｎ２、γ＇－Ｆｅ４Ｎ和ε－Ｆｅ２￣３Ｎ相的纳米多晶薄膜。Ｆｅ－Ｎ薄膜的磁性取决于膜层的相结构及微观形貌。纳米尺度的α″－Ｆｅ１６Ｎ２和α－Ｆｅ相的混合物膜层的饱和磁性强度可达２４５ｅｍｕ／ｇ。多元ＩＢＥＤ Ｆｅ－Ｃｏ－Ｎ合金薄膜与相同制备条件下合成的Ｆｅ－Ｎ薄膜相比，其相结构相似，但饱和     

相似理论与界面液膜技术

讨论了界面液膜(ILM)技术和相似理论之间的关系。应用因次分析法,由ILM的主要物理参数导出了流体动量传递阻力准数R_L~*、R_L,热量传递阻力准数R_H~*、R_H,质量传递阻力准数R_M~*、R_M(*代表非定常),浮阻准数R_(by)和膜能准数E_σ。在ILM中快速高效的流体动量、热量和质量传递得到R_L、R_H和R_M很好的阐明。应用R_L、R_(by)和E_σ表达单个ILM、固粒、液滴或气泡在流体中的运动方程式比应用Re、Ly、Ar和Ga更为简明。     

Effect of glucocorticoids on the appearance of gamma-glutamyl transpeptidase activity in primary cultures of adult rat hepatocytes

Primary cultures of adult rat liver parenchymal cells showed a progressive rise of gamma-glutamyl transpeptidase (GGT) activity (E.C. 2.3.2.2) after the first 5 days of culture. The presence of dexamethasone and other synthetic glucocorticoids in the culture medium partially prevented this increase.     

两种工业用Al_2O_3吸附剂的结构和性质的研究

对用于净化对苯二甲酸生产中循环氮气的氧化铝吸附剂G(德国制)和W(国产),进行了结构和性质的研究。根据经不同温度熔烧的样品的X光衍射图,确定G的主要物相为η-Al_2O_3,混有少量薄水铝石;W的主要物相为薄水铝石,混有少量拟薄水铝石。这一结论又通过再水合后样品的X光衍射图得到肯定。这两种氧化铝吸附剂在孔结构,表面性质和吸附性能上都显示出明显的差别。故在应用时不宜轻易互换替代。     

Beitrag zur Frage der Entstehung mehrkerniger Zellen

Summary The author describes the origin of 2 daughter cells of HeLa cellular line: one double nuclear and the other single nuclear cell. Both cells origined by the mitotic division of the single nuclear mother cell without any artificial treatment. The observation is documented by the series of partial photographs of the time-lapse cine-film.     

战略人力资源管理学说

对“战略人力资源管理”这一人力资源管理领域新内容的基本范畴进行简要的阐述,并阐述了其发展背景和理论与实践价值,进而对战略人力资源管理竞争环境的定位、组织发展阶段定位、人力资源管理特征、组织变革战略、人力资源人员与工作角色方面的主要学说进行了介绍。对“战略人力资源管理”这一人力资源管理领域新内容的基本范畴进行简要的阐述,并阐述了其发展背景和理论与实践价值,进而对战略人力资源管理竞争环境的定位、组织发展阶段定位、人力资源管理特征、组织变革战略、人力资源人员与工作角色方面的主要学说进行了介绍。     

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, characterized respectively by a high or low number of somatic hypermutations in the variable region of immunoglobulin genes. The molecular changes leading to the pathogenesis of the disease are still poorly understood. Here we performed whole-genome sequencing of four cases of CLL and identified 46 somatic mutations that potentially affect gene function. Further analysis of these mutations in 363 patients with CLL identified four genes that are recurrently mutated: notch 1 (NOTCH1), exportin 1 (XPO1), myeloid differentiation primary response gene 88 (MYD88) and kelch-like 6 (KLHL6). Mutations in MYD88 and KLHL6 are predominant in cases of CLL with mutated immunoglobulin genes, whereas NOTCH1 and XPO1 mutations are mainly detected in patients with unmutated immunoglobulins. The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease. To our knowledge, this is the first comprehensive analysis of CLL combining whole-genome sequencing with clinical characteristics and clinical outcomes. It highlights the usefulness of this approach for the identification of clinically relevant mutations in cancer.