多通道SAR-GMTI二维间歇采样延时转发干扰

为充分降低合成孔径雷达地面动目标显示(synthetic aperture radar-ground moving target indication, SAR-GMTI)对地面重要运动目标的威胁,本文在SAR间歇采样转发干扰技术基础上,针对多通道SAR-GMTI提出了二维间歇采样慢时间延时转发干扰方法。该方法利用二维间歇采样实现干扰信号的二维频谱周期性拓展,从而生成无法被SAR-GMTI完全对消的假目标群,并进一步提出采用慢时间延时转发来实现对假目标群方位向位移的控制。在此基础上,针对SAR-GMTI的对消特性给出了多组延时转发干扰应用模型。理论分析和仿真实验表明:该方法可对多通道SAR-GMTI产生二维假目标群,且假目标幅度受正弦调制函数的影响出现增强和削弱,多组延时转发干扰方法可以实现增强区与削弱区互补,从而形成分布更密集、覆盖范围更广的二维多假目标干扰效果。     

基于主成分回归分析的瓦斯含量预测

为了增加多元回归模型预测的精度,将主成分分析与多元回归分析相结合提出了PCA—MRA模型,并将该模型用于实际瓦斯含量预测。结果表明,PCA—MRA模型消除了输入变量之间的相关性,减少了输入变量值个数,提高了预测精度,便于实际推广和应用,为瓦斯含量预测提供一种新的途径。     

Evidence for the intracellular accumulation of anandamide in adiposomes

Anandamide is a lipid messenger that carries out a wide variety of biological functions. It has been suggested that anandamide accumulation involves binding to a saturable cellular component. To identify the structure(s) involved in this process, we analyzed the intracellular distribution of both biotinylated and radiolabeled anandamide, providing direct evidence that lipid droplets, also known as adiposomes, constitute a dynamic reservoir for the sequestration of anandamide. In addition, confocal microscopy and biochemical studies revealed that the anandamide-hydrolase is also spatially associated with lipid droplets, and that cells with a larger adiposome compartment have an enhanced catabolism of anandamide. Overall, these findings suggest that adiposomes may have a critical role in accumulating anandamide, possibly by connecting plasma membrane to internal organelles along the metabolic route of this endocannabinoid. S. Oddi, F. Fezza: These authors contributed equally to the study.     

Common variants near MC4R are associated with fat mass, weight and risk of obesity

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) = 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits.     

在线签名鉴别的改进DTW算法

论述一种改进的在线签名鉴别算法,在原有的应用DTW算法基础上,在所需鉴别签名的动态特征中加入角度特征,克服了规整中将两个签名中的同一笔画规整成不同的笔画的弊端,提高了鉴别的准确率.同时,提出的选取最优化样本的方法更好地增强了在线签名的实时性,并且通过反复试验得以验证.     

3-N-丙酰基-2-芳基-5-(2-氯苯基)-1,3,4-(口恶)唑啉类化合物的合成

2-氯苯甲酰肼(2)与芳醛反应得到相应的酰腙(3a~3h),而后与丙酸酐脱水环化成了3-N-丙酰基-2-芳基-5-(2-氯苯基)-1,3,4-唑啉类化合物(4a~4h),通过元素分析,IR,1H NMR和MS对化合物4a~4h的结构进行了表征.     

2-芳基-3-N-丙酰基-5-(4-碘苯基)-1,3,4-(口恶)唑啉类化合物的合成

4-碘苯甲酰肼(2)与芳醛反应得到相应的酰腙(3a～3i),而后与丙酸酐脱水环化成了2-芳基-3-N-丙酰基-5-(4-碘苯基)-1,3,4-(口恶)唑啉类化合物(4a～4i),通过元素分析、IR、1H NMR和MS方法对化合物4a～4i的结构进行了表征.     

尺寸对无限长条功能梯度材料裂尖应力场影响

假设剪切摸量沿厚度方向连续且为指数形式模型,给出了含有限长裂纹的无限长条功能梯度材料在反平面剪应力载荷作用下的裂纹问题。利用非局部线弹性理论和积分变换方法,将混合边界值问题简化对偶积分方程,最后通过Schmidt方法对裂纹尖端的应力场和位移场进行了求解。与经典理论的解答不同,裂纹尖端应力为有限值,裂纹尖端应力幅值随长条高度的增加而降低。     

支持向量机法预测苯砜基环烷酸酯类化合物的色谱保留

应用支持向量机方法研究了28种苯砜基环烷酸酯类化合物的色谱保留和分子结构的定量关系,结果发现,采用支持向量机方法可以实现使用较少样本数据建模,并达到较好预测结果的目的．支持向量机方法的预测结果远优于线性溶解能关系法的预测结果．     

镍诱导纳米晶硅薄膜的生长

采用磁控溅射方法制备了含镍过渡层的富纳米晶硅二氧化硅薄膜．对薄膜退火后的微观结构和发光性能进行了试验分析．结果表明,在高温退火后,有Ni过渡层的富纳米晶硅薄膜较没有Ni过渡层的薄膜具有更高的纳米晶硅密度和更强的室温光致发光强度．对试验结果进行热力学分析后,认为NiSi2作为纳米晶硅的形核中心诱导了薄膜的分相和纳米晶硅生长．