全文获取类型
收费全文 | 11858篇 |
免费 | 24篇 |
国内免费 | 42篇 |
专业分类
系统科学 | 35篇 |
丛书文集 | 80篇 |
教育与普及 | 30篇 |
理论与方法论 | 42篇 |
现状及发展 | 5127篇 |
研究方法 | 565篇 |
综合类 | 5889篇 |
自然研究 | 156篇 |
出版年
2013年 | 96篇 |
2012年 | 191篇 |
2011年 | 330篇 |
2010年 | 85篇 |
2009年 | 59篇 |
2008年 | 190篇 |
2007年 | 222篇 |
2006年 | 204篇 |
2005年 | 224篇 |
2004年 | 208篇 |
2003年 | 207篇 |
2002年 | 198篇 |
2001年 | 379篇 |
2000年 | 364篇 |
1999年 | 263篇 |
1992年 | 232篇 |
1991年 | 180篇 |
1990年 | 204篇 |
1989年 | 191篇 |
1988年 | 201篇 |
1987年 | 206篇 |
1986年 | 162篇 |
1985年 | 248篇 |
1984年 | 170篇 |
1983年 | 149篇 |
1982年 | 166篇 |
1981年 | 135篇 |
1980年 | 170篇 |
1979年 | 385篇 |
1978年 | 292篇 |
1977年 | 287篇 |
1976年 | 249篇 |
1975年 | 288篇 |
1974年 | 309篇 |
1973年 | 308篇 |
1972年 | 344篇 |
1971年 | 344篇 |
1970年 | 428篇 |
1969年 | 361篇 |
1968年 | 381篇 |
1967年 | 351篇 |
1966年 | 319篇 |
1965年 | 203篇 |
1959年 | 107篇 |
1958年 | 204篇 |
1957年 | 137篇 |
1956年 | 122篇 |
1955年 | 105篇 |
1954年 | 81篇 |
1948年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
911.
Summary To determine whether the colonic transit accelerating effect of (–)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.) was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors. 相似文献
912.
913.
Mammalian pineal melatonin: a clock for all seasons 总被引:9,自引:0,他引:9
The central role of the pineal gland and its hormone melatonin (MEL) in mammalian photoperiodic responses is discussed in terms of: 1) evidence for the involvement of MEL in photoperiodism, 2) which feature of the MEL secretion profile might be most important for regulating photoperiodic responses, 3) evidence for the modulation of responses to changes in daylength based on previous photoperiod exposure (i.e., photoperiodic history) and 4) how the MEL signal might be processed at its target sites to elicit physiological responses. 相似文献
914.
Cell biology. Tracking an elusive receptor 总被引:3,自引:0,他引:3
915.
The spectrum of a chromophore may change as a result of perturbations in its environment. The spectral changes resulting from the perturbation are often followed by measurements at just one or two wavelengths but it is usually no more difficult to collect entire spectra. The problem comes in analysing the data from such a series of spectra. In this paper we will suggest a simple procedure in which the spectrum observed under any particular set of conditions may be considered to consist of the sum of two distinct spectral forms. The method, which is free of any assumptions regarding the quantitative relationship between the perturbation and the extent of spectral change, defines any given spectrum in terms of an apparent molar fraction of the contributing spectral forms. The variation of this apparent molar fraction provides information from which a quantitative relationship can be developed to describe the dependence of the spectral change on the perturbant. The method is illustrated using the model system of phenol red protonation and is applied to the characterization of the binding of azide ions to cobalt-substituted carbonic anhydrase. 相似文献
916.
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours 总被引:50,自引:0,他引:50
A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein alpha chain, alpha(s). The resulting activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone. Amino acids substituted in the putative gsp oncogene identify a domain of G protein alpha-chains required for intrinsic ability to hydrolyse GTP. This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras. 相似文献
917.
Studies with isolated rat adrenocortical cells have shown that neuropeptide Y (NPY) inhibits both basal and ACTH-stimulated corticosterone secretion. These results suggest the regulatory role of NPY in corticosterone secretion from the adrenal gland, especially during stress. 相似文献
918.
O. B. Sheynin 《Archive for History of Exact Sciences》1989,39(4):337-377
Communicated by
H. Freudenthal 相似文献
919.
Oxide to metal conversion is one of the most energy-intensive steps in the value chain for metals production. Solid oxide membrane (SOM) electrolysis process provides a general route for directly reducing various metal oxides to their respective metals, alloys, or intermetallics. Because of its lower energy use and ability to use inert anode resulting in zero carbon emission, SOM electrolysis process emerges as a promising technology that can replace the state-of-the-art metals production processes. In this paper, a careful study of the SOM electrolysis process using equivalent DC circuit modeling is performed and correlated to the experimental results. A discussion on relative importance of each resistive element in the circuit and on possible ways of lowering the rate-limiting resistive elements provides a generic guideline for designing optimum SOM electrolysis cells. 相似文献
920.
Richard B. Watson 《Systemic Practice and Action Research》2012,25(5):441-456
Soft systems methodology (SSM) is now 40?years old. Another decade has passed since Checkland??s thirty year retrospective on the methodology, published in 2000. It can now be described as an old methodology. But it has adapted and changed over the years and is still very much alive, although the days are long gone when it was mainly developed and practised by its founders at the University of Lancaster. Interestingly, considering that many applications of SSM over the years have been to information systems, it was developed before the age of personal computers and the Internet. The way SSM is viewed has changed over the years as it has been applied to various types of problem situation. Every use of SSM will potentially hold methodological lessons in addition to those about the situation of concern; these may include SSMs framework of ideas, processes and way of use. How is SSM going to change in the future? This will depend in part on the types of problem situation to which it is applied. This paper examines some problem situations associated with emerging technologies in the information age to which SSM has not yet been much applied. These include computer simulation and virtual reality, ubiquitous computing and the design of cities, Information Technology Service Management and the design of enterprise information architectures. Some of the different worldviews associated with these problem situations which could be explored using SSM are noted. 相似文献