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971.
龙门山中段茂汶─汶川韧性剪切带中可见到绿片岩相到角闪岩相的古生界。该地的巴罗型中压变质相相当于松潘—甘孜褶皱带中地壳的绿泥石带,构成了北东—南西向的茂汶—汶川变质带。雪隆包花岗岩体正位于该变质带的中心部位。三次韧性变形作用(D1~D3)造就了印支褶皱带,并在三叠纪末末形成了松潘—甘孜褶皱带。D1变形作用为北东—南西向的挤压作用和冲断作用,形成了大型的等斜褶皱,使古生界缩短和加厚。在持续的D2北京—南西向挤压作用下,松潘—甘孜褶皱带和稳定的扬子克拉通之间的差异应变由茂汶—汶川剪切带中非同轴左旋剪切作用所容纳。雪隆包花岗岩体是在D2变形作用的晚期侵入到剪切带的。产生蓝晶石的变质条件也是在D2或D2变形作用后出现的。D3变形作用为北西—南东向挤压,在局部地方形成糜棱岩状的道冲剪切带。这些特征与绿泥石退变质作用有关,揭示出在D3变形期间茂汶—汶川变质带有较大幅度的隆升。尽管雪隆包岩体在空间上与茂汶—汶川变质带有关,但作者认为其变质作用是岩层加厚引起的热作用重新达到平衡的产物,而不是由侵入作用引起的热接触变质作用。然而,与岩浆作用伴生的高温和活动性流体仍是产生D3局部变形和雪隆包岩体隆升的原因,这也是局部出现角闪告相  相似文献   
972.
本文使用SEM、EDS、EAS、XRD和电阻率测量技术,研究了工艺参数和加入(Co,Fe2O3)对PTC(V1-x,Crx)2O3陶瓷的显微结构和电性能的影响。实验结果表明,为了制造优良性能、高可靠的热敏电阻器,必须精确控制陶瓷组份和工艺。引人象C。这样的添加物是重要的,它主要以金属形式分布在基体中,同时发现添加物对试样致密度和电性能的影响也是有益的。  相似文献   
973.
燃烧室偶合系统不稳定传热的数值分析   总被引:2,自引:0,他引:2  
本文在轴对称不稳定热传导有限元分析模型的基础上,提出了一个内燃机燃烧室的活塞与缸套偶合系统的不稳定传热数值分析模型。该模型考虑了在燃气与边界的对流和热幅射非线性热交换条件下运动着的活塞、活塞环、缸套和润滑油膜之间在传热过程中的相互作用和影响,可以预测上述系统各部分的温度波动分布、瞬态温度场以及瞬态热流分布。  相似文献   
974.
A Peterson  B Seed 《Nature》1987,329(6142):842-846
The human T cell erythrocyte receptor (CD2 antigen) allows thymocytes and mature T cells to adhere to thymic epithelium and target cells through a cell surface protein, LFA-3 (refs 1-6). Monoclonal antibodies recognizing CD2 can either block adhesion or, in certain combinations, induce an antigen-independent T cell activation. We have identified the binding sites for 16 monoclonal antibodies against CD2 by a rapid and generally applicable mutational analysis. The binding sites fall in three discrete regions: antibodies that participate in activation and block erythrocyte adhesion bind to the first region; antibodies that block adhesion bind to the second region; and antibodies that participate in activation but do not block adhesion bind to the third region. A large number of mutations selected for loss of antibody reactivity in the first two regions also weaken the CD2-LFA-3 interaction. Good agreement was observed between mutational lesions blocking LFA-3 binding and lesions blocking binding by activating antibodies, which supports the view that such antibodies induce T cell activation by mimicking the effect of LFA-3 binding. CD2 sequences that participate in LFA-3 binding correspond to immunoglobulin variable region hypervariable sequences when the homologous domains are aligned.  相似文献   
975.
Decay-accelerating factor (DAF), a glycoprotein that is anchored to the cell membrane by phosphatidylinositol, binds activated complement fragments C3b and C4b, thereby inhibiting amplification of the complement cascade on host cell membranes. Here, we report the molecular cloning of human DAF from HeLa cells. Analysis of DAF complementary DNAs revealed two classes of DAF messenger RNA, one apparently derived from the other by a splicing event that causes a coding frameshift near the C terminus. The apparent 'intron' sequence contains an Alu family member and encodes contiguous protein sequence. Two DAF proteins are therefore possible, having divergent C-terminal domains which differ in their hydrophobicity. Both mRNAs are found on polysomes, suggesting that both are translated. We propose that the major (90%) spliced DAF mRNA encodes membrane-bound DAF whereas the minor (10%) unspliced DAF mRNA may encode secreted DAF and we present expression data supporting this. The deduced DAF sequence contains four repeating units homologous to a consensus repeat found in a recently described family of complement proteins.  相似文献   
976.
R H Scott  A C Dolphin 《Nature》1987,330(6150):760-762
The activation of a guanine nucleotide binding (G) protein is an essential step in coupling certain receptors to the inhibition of voltage-activated calcium channels. We have previously observed that analogues of GTP potentiate the effect of receptor agonists and inhibit calcium currents in cultured dorsal root ganglion (DRG) neurones. A residual sustained 'L-type' component of the calcium channel current is resistant to inhibition by internal guanosine 5'-O-3-thiotriphosphate (GTP-gamma-S). Because calcium channel antagonists such as D600, nifedipine and diltiazem inhibit L currents, we examined their effect on GTP-gamma-S-modified currents. These compounds all produced a rapid and very marked potentiation of calcium channel currents in the presence of internal GTP-gamma-S and this effect was prevented by pertussis toxin which ADP ribosylates the G proteins Gi/Go (for review see ref. 10). We suggest that this potentiation indicates that activated G protein can interact with the calcium channel, and that this enhances the action of calcium channel ligands at their agonist sites on the channel in its resting state. These results represent the first electrophysiological evidence that guanine nucleotides are able to influence cellular responses to calcium channel ligands.  相似文献   
977.
Patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related conditions are known to have abnormalities of T cell subpopulations, including a decreased helper/inducer (bearing the CD4 antigen) to suppressor/cytotoxic (bearing the CD8 antigen) T cell ratio and decreased absolute numbers of T cells with the CD4+ phenotype. Infection of T cells with a retrovirus, termed human immunodeficiency virus (HIV), is thought to be important in these abnormalities. HIV infection alone does not adequately explain the CD4+ T-cell abnormalities seen in AIDS, however, and the nature of T-cell destruction in this disease remains poorly characterized. Here we describe an AIDS-related serum autoantibody that reacts with an antigen of relative molecular mass 18,000 (Mr 18K) restricted to lectin-stimulated or HIV-infected CD4+ T cells. The antibody also suppresses proliferation of CD4+ T cells in vitro and induces cytotoxicity of these cells in the presence of complement. Its role in the development of AIDS merits attention.  相似文献   
978.
Cell-free extracts prepared from human 293 cells, supplemented with purified SV40 large-T antigen, support replication of plasmids containing the SV40 origin of DNA replication. A cellular protein (Mr approximately 36,000) that is required for efficient SV40 DNA synthesis in vitro has been purified from these extracts. This protein is recognized by human autoantibodies and is identified as the cell-cycle regulated protein known as proliferating cell nuclear antigen (PCNA) or cyclin.  相似文献   
979.
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage   总被引:11,自引:0,他引:11  
Multiple endocrine neoplasis type 2A (MEN2A) is one of several kinds of cancers that appear to be inherited in an autosomally dominant fashion. We have assigned the MEN2A locus to chromosome 10 by linkage with a new DNA marker (D10S5). The linkage led us to investigate other chromosome 10 markers and demonstrate linkage between the disease locus and the interstitial retinol-binding protein (IRBP) gene. The D10S5 locus was sublocalized to 10q21.1 by hybridization in situ and the IRBP gene to p11.2----q11.2 with a secondary site at q24----q25. The linkages were established using 292 members of five families, three different restriction fragment length polymorphisms (RFLPs) at D10S5 and two RFLPs recognized by the IRBP probe. The recombination frequencies from pairwise linkage analysis between the disease and two marker loci D10S5 and IRBP were 0.19 and 0.11, with maximum lod scores of 3.6 and 8.0 respectively. Ordering of the three loci by multipoint analysis placed the IRBP gene approximately midway between the disease and D10S5 loci.  相似文献   
980.
Early reports that acyclic analogues of oxytocin and vasopressin (AVP) have drastically reduced agonistic activities established as dogma that an intact hexapeptide ring structure is essential for the pharmacological activities of analogues of neurohypophysial hormones. Thus, virtually all the many hundreds of agonistic and antagonistic analogues of the neurohypophysial peptides that have been reported contain an intact ring. Here we report that an intact ring is not essential for binding of antagonistic AVP analogues to vasopressor (V1) or antidiuretic (V2) AVP receptors. In fact, one acyclic AVP analogue seems to be about as potent as any previously reported cyclic V2 antagonist. This finding suggests new possibilities for the design of AVP analogues as pharmacological probes and for therapeutic use. Similar modifications might be useful in the design of analogues of other cyclic peptides, such as calcitonin, somatostatin and the atrial natriuretic factors.  相似文献   
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