排序方式: 共有66条查询结果,搜索用时 12 毫秒
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通过实验研究了不同加载方式下的煤岩破坏电磁辐射记忆效应特性;借助细观损伤力学和电磁动力学等理论,对煤岩内部结构损伤扩展及电磁辐射产生机制进行了分析。结果表明,煤岩破坏电磁辐射具有记忆效应特性,但记忆最大历史应力、纵向应变的能力明显优于记忆横向应变和体应变的能力,受载煤岩损伤破坏过程的不可逆性是煤岩破坏电磁辐射产生记忆效应的直接原因。 相似文献
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Pearson RA Barber AC Rizzi M Hippert C Xue T West EL Duran Y Smith AJ Chuang JZ Azam SA Luhmann UF Benucci A Sung CH Bainbridge JW Carandini M Yau KW Sowden JC Ali RR 《Nature》2012,485(7396):99-103
Cell transplantation is a potential strategy for treating blindness caused by the loss of photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult retina and differentiate to acquire the specialized morphological features of mature photoreceptor cells, the fundamental question remains whether transplantation of photoreceptor cells can actually improve vision. Here we provide evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1?/? mice, which lack rod function and are a model of congenital stationary night blindness. We show that transplanted rod precursors form classic triad synaptic connections with second-order bipolar and horizontal cells in the recipient retina. The newly integrated photoreceptor cells are light-responsive with dim-flash kinetics similar to adult wild-type photoreceptors. By using intrinsic imaging under scotopic conditions we demonstrate that visual signals generated by transplanted rods are projected to higher visual areas, including V1. Moreover, these cells are capable of driving optokinetic head tracking and visually guided behaviour in the Gnat1?/? mouse under scotopic conditions. Together, these results demonstrate the feasibility of photoreceptor transplantation as a therapeutic strategy for restoring vision after retinal degeneration. 相似文献
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目的:研究高河菜提取物对小鼠消化道动力的影响.方法:采用炭末推进实验观察高河菜提取物对阿托品所致小鼠小肠推进抑制的影响;采用甲基橙胃残留率的方法观察高河菜提取物对阿托品所致小鼠胃排空抑制的影响.结果:高河菜提取物2g/kg能明显拮抗阿托品对小鼠小肠推进抑制的作用;高河菜提取物2g/kg、1g/kg和0.5g/kg均能拮抗阿托品对小鼠胃排空抑制的作用.结论:高河菜提取物对阿托品所致小鼠胃肠功能障碍有明显的改善作用. 相似文献