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31.
Allen Clark Dotson 《Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics》2012,43(1):64-68
Karl Popper and Herbert Dingle engaged in a fascinating debate concerning the kind of theory the special theory of relativity is. One of the issues was whether applications of the theory could be made consistent with the principle of relativity, a cornerstone of the theory itself. The principle of relativity seems to imply some sort of symmetry in results obtained for similar experiments as observed in two different inertial reference frames. Peter Hayes has recently dealt with the Dingle–Popper debate on this matter, as well as other issues. The present paper seeks to clarify what kind of symmetry is appropriate in a situation discussed by Popper, Dingle, and Hayes. 相似文献
32.
Birthday present for digitalis 总被引:1,自引:0,他引:1
33.
F. Carlei J. M. Allen A. E. Bishop S. R. Bloom J. M. Polak 《Cellular and molecular life sciences : CMLS》1985,41(12):1554-1557
Summary Significant quantities of a newly discovered peptide, neuropeptide Y, were found in the rat pancreas, where they were localized to nerves in the exocrine parenchyma and around arterial and ductal structures. Although unaffected by surgical parasympathectomy, the periarterial and periductal nerves were abolished by chemical sympathectomy, suggesting that NPY is partially costored with sympathetic transmitters in nerve fibers. 相似文献
34.
Sensory deprivation produced by removing the eyes and olfactory bulbs in male rats allowed pinealectomy to markedly augment the post-adrenalectomy elevation of ACTH levels. Pineal removal or sensory deprivation separately did not have this effect. Thus, intact sensory input and an intact pineal gland are independently capable of restricting the post-adrenalectomy rise in ACTH levels. 相似文献
35.
Directed intracellular particle movement is a fundamental process characteristic of all cells. During fast axonal transport, membranous organelles move at rapid rates, from 1 to 5 micron s-1, in either the orthograde or retrograde direction along the neurone and can traverse distances as long as 1 m (for reviews, see refs 1-3). Recent studies indicate that this extreme example of intracellular motility can occur along single microtubules, but the molecules generating the motile force have not been identified or localized. It is not known whether the force-transducing 'motor' is associated with the moving particle or with the microtubule lattice. To distinguish between these hypotheses and to characterize the membrane-cytoskeletal interactions that occur during vesicle translocations, we have developed a reconstituted model for microtubule-based motility. We isolated axoplasmic vesicles from the giant axon of the squid Loligo pealei as described previously. The vesicles (35-475 nm in diameter) were then added to axonemes of Arbacia punctulata spermatozoa that served as a source of microtubules. Axonemes were used because the tubulin subunit lattice of the A-subfibre of a given outer doublet is the same as the subunit lattice of neuronal microtubules along which motility occurs. Moreover, all the microtubules of a single axoneme show the same structural polarity, indicating that the axoneme represents an oriented microtubule substrate. Here we demonstrate that vesicle motility is ATP-dependent, that it is not mediated by the flagellar force-transducing molecule dynein and that the direction of movement is not specified by microtubule polarity. 相似文献
36.
Gelsolin inhibition of fast axonal transport indicates a requirement for actin microfilaments 总被引:2,自引:0,他引:2
The actions of actin-based microfilaments in cell motility suggest a possible role in the mechanism of fast axonal transport, but the pharmacological data evaluating their role in this process are equivocal. Moreover, microfilaments are difficult to preserve and identify in ultrastructural studies, so the organization and function of axonal actin has remained uncertain. We have now evaluated the role of actin microfilaments in intracellular transport of membranous organelles using video-enhanced contrast microscopy and gelsolin to analyse fast axonal transport directly in isolated axoplasm from the squid giant axon. With this preparation it is possible to perfuse axoplasm with large molecules that do not cross the plasmalemma, while controlling cation levels. The 90,000-molecular weight protein gelsolin depolymerizes actin microfilaments in micromolar Ca2+, but not in the absence of Ca2+. Axonal transport of membranous organelles has previously been shown to be unaffected by levels of Ca2+ up to 10 microM. In the presence of EGTA, gelsolin has no effect on the movement of membranous organelles, but in the presence of 10 microM Ca2+ it completely blocks transport of all membranous organelles. No changes in the organization of the axoplasm were detected. These results and results using other probes for actin are consistent with the hypothesis that actin-based microfilaments are involved in the movement of membranous organelles in the axon. 相似文献
37.
Allen F. Sherald 《Cellular and molecular life sciences : CMLS》1980,36(2):143-146
Summary Evidence indicating linkage between the processes of cuticle hardening and coloration are reviewed. Data and observations for the mutants black and ebony inDrosophila melanogaster are used to construct a possible model for the relationship between these developmental events. 相似文献
38.
G. M. Vaughan J. P. Allen M. K. Vaughan T. M. Siler-Khodr 《Cellular and molecular life sciences : CMLS》1980,36(3):364-366
Summary Sensory deprivation produced by removing the eyes and olfactory bulbs in male rats allowed pinealectomy to markedly augment the post-adrenalectomy elevation of ACTH levels. Pineal removal or sensory deprivation separately did not have this effect. Thus, intact sensory input and an intact pineal gland are independently capable of restricting the post-adrenalectomy rise in ACTH levels.This work was supported in part by NIH Grant No. P30 HD 10202. We thank F. Lynd and R.J. Reiter for advice, P. Starr and J. Sackman for technical assistance, and Bess Mitchell for typing. 相似文献
39.
Juan D. Delius Gillian Thompson Keith L. Allen Jacky Emmerton 《Cellular and molecular life sciences : CMLS》1972,28(10):1244-1246
Zusammenfassung Junggeschlüpfte Silber- und Heringsmöven zeigen beim Picken von kleinflächigen, beweglichen Reizen Spektralfarbbevorzugungen. Drei theoretische Modelle sind vorgeschlagen worden, die diese Bevorzugungen erklären sollen. Die Voraussagen dieser Modelle bezüglich der Bevorzugung von Mischfarben wurden experimentell geprüft und als nicht zutreffend befunden. Vielmehr legen die Ergebnisse die Vermutung nahe, dass die Bevorzugung nicht, wie bisher angenommen, auf einem afferenten sensorischen Filtermechanismus beruht, sondern auf einen mehr zentralen, postperzeptualen Prozess zurückzuführen ist. 相似文献
40.
C. Nations R. G. Allen K. J. Farmer P. L. Toy R. S. Sohal 《Cellular and molecular life sciences : CMLS》1986,42(1):64-66
Summary Superoxide dismutase activity was slow throughout the cell cycle of surface cultures ofPhysarum polycephalum. This activity increased markedly when the organism was induced to spherulate. Glutathione (GSH) and hydrogen peroxide (H2O2) concentrations changed very little during the cell cycle. During spherulation GSH decreased; H2O2 and the cyanide-resistant respiration of plasmodial homogenates increased. 相似文献