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171.
Most craters found on Earth are highly eroded, poorly preserved and only exposed on land. Here we describe a multi-ringed impact structure discovered in the North Sea from the analysis of three-dimensional seismic reflection data. The structure is 20 km in diameter, and has at least ten distinctive concentric rings located between 2 and 10 km from the crater centre. The structure affects Cretaceous chalk and Jurassic shales, and is well preserved below several hundred metres of post-impact Tertiary strata, which constrains its age to be 60-65 Myr old. The formation of concentric ringed impact structures at this relatively small scale had not previously been thought possible, especially on the terrestrial planets. We have mapped the ring structures at a resolution of tens of metres both laterally and in depth, and show that the rings are fault-bounded graben structures, similar to fault arrays formed in low-strain-rate detachment tectonic settings. Strata deeper than 500 m palaeodepth appear unfaulted, and we infer that the concentric ring structures may have accommodated post-impact extension towards the excavated crater, through detachment on weak layers within the chalk. 相似文献
172.
Lindskog M Svenningsson P Pozzi L Kim Y Fienberg AA Bibb JA Fredholm BB Nairn AC Greengard P Fisone G 《Nature》2002,418(6899):774-778
Caffeine has been imbibed since ancient times in tea and coffee, and more recently in colas. Caffeine owes its psychostimulant action to a blockade of adenosine A(2A) receptors, but little is known about its intracellular mechanism of action. Here we show that the stimulatory effect of caffeine on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000). Results virtually identical to those seen with caffeine were obtained with the selective A(2A) antagonist SCH 58261. The depressant effect of the A(2A) receptor agonist, CGS 21680, on motor activity was also greatly attenuated in DARPP-32 knockout mice. In support of a role for DARPP-32 in the action of caffeine, we found that, in striata of intact mice, caffeine increased the state of phosphorylation of DARPP-32 at Thr 75. Caffeine increased Thr 75 phosphorylation through inhibition of PP-2A-catalysed dephosphorylation, rather than through stimulation of cyclin-dependent kinase 5 (Cdk5)-catalysed phosphorylation, of this residue. Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine. 相似文献
173.
Development of anisotropic structure in the Earth's lower mantle by solid-state convection 总被引:2,自引:0,他引:2
Seismological observations reveal highly anisotropic patches at the bottom of the Earth's lower mantle, whereas the bulk of the mantle has been observed to be largely isotropic. These patches have been interpreted to correspond to areas where subduction has taken place in the past or to areas where mantle plumes are upwelling, but the underlying cause for the anisotropy is unknown-both shape-preferred orientation of elastically heterogeneous materials and lattice-preferred orientation of a homogeneous material have been proposed. Both of these mechanisms imply that large-strain deformation occurs within the anisotropic regions, but the geodynamic implications of the mechanisms differ. Shape-preferred orientation would imply the presence of large elastic (and hence chemical) heterogeneity whereas lattice-preferred orientation requires deformation at high stresses. Here we show, on the basis of numerical modelling incorporating mineral physics of elasticity and development of lattice-preferred orientation, that slab deformation in the deep lower mantle can account for the presence of strong anisotropy in the circum-Pacific region. In this model-where development of the mineral fabric (the alignment of mineral grains) is caused solely by solid-state deformation of chemically homogeneous mantle material-anisotropy is caused by large-strain deformation at high stresses, due to the collision of subducted slabs with the core-mantle boundary. 相似文献
174.
The purpose of these experiments was to compare the contractile response to ACh of stomach fundal strips from hypertensive (SHR) and normotensive (WKY) rats during the development of hypertension. The results indicate that the reactivity to ACh is the same in fundal strips from young SHR and WKY rats; however, with maturation strips from WKY rats undergo a reduction in responsiveness which does not occur in the SHR. Therefore, strips from older SHR rats are more reactive to ACh than are those from age matched WKY rats. 相似文献
175.
Calcium transients in aequorin-injected frog cardiac muscle. 总被引:26,自引:0,他引:26
The Ca2+ -sensitive bioluminescent protein aequorin was microinjected into cells of frog atrial trabeculae to study intracellular calcium transients associated with excitation-contraction coupling. The amplitude of the aequorin signal increased with extracellular Ca2+ concentration and stimulus frequency, but decreased with stretch. Isoprenaline and acetylstrophanthidin both increased the amplitude, but had strikingly different effects on the time course of the signal. 相似文献
176.
Imagination suggests that the computer as a communication tool is potentially a significant factor in enhancing cooperative work, especially where the participants are located over a physical or temporal distance. Implementation of innovative information technology offers enhancement of operational efficiency to an enterprise in a turbulent business environment. Communications and decision making are inseparable. Industrial democracy (ID) is a particular arrangement of decisionmaking power where decision makers have to be informed and decisions have to be communicated. Cooperation implies a redistribution of power and the weakening of the traditional management organizational heirarchy. Cogently, this effect is mirrored by the potential of management information systems to redistribute information and, hence, power within an enterprise. The response of traditional management personnel to the threat of information technology (IT) to established positions of authority, is one of defense. Conventional systems analysis is unsuited for the design task of ID information systems. The methods employed by systems analysis preserve or reproduce the formal hierarchical structure of managerial organization. Soft systems methodology is explored as a means of confronting the sociopolitical factors present in the specification of information systems for an ID. 相似文献
177.
Schreiner PR Reisenauer HP Pickard FC Simmonett AC Allen WD Mátyus E Császár AG 《Nature》2008,453(7197):906-909
Singlet carbenes exhibit a divalent carbon atom whose valence shell contains only six electrons, four involved in bonding to two other atoms and the remaining two forming a non-bonding electron pair. These features render singlet carbenes so reactive that they were long considered too short-lived for isolation and direct characterization. This view changed when it was found that attaching the divalent carbon atom to substituents that are bulky and/or able to donate electrons produces carbenes that can be isolated and stored. N-heterocyclic carbenes are such compounds now in wide use, for example as ligands in metathesis catalysis. In contrast, oxygen-donor-substituted carbenes are inherently less stable and have been less studied. The pre-eminent case is hydroxymethylene, H-C-OH; although it is the key intermediate in the high-energy chemistry of its tautomer formaldehyde, has been implicated since 1921 in the photocatalytic formation of carbohydrates, and is the parent of alkoxycarbenes that lie at the heart of transition-metal carbene chemistry, all attempts to observe this species or other alkoxycarbenes have failed. However, theoretical considerations indicate that hydroxymethylene should be isolatable. Here we report the synthesis of hydroxymethylene and its capture by matrix isolation. We unexpectedly find that H-C-OH rearranges to formaldehyde with a half-life of only 2 h at 11 K by pure hydrogen tunnelling through a large energy barrier in excess of 30 kcal mol(-1). 相似文献
178.
Diurnal shedding by retinal rods was studied in wild cutthroat trout,Oncorhyncus clarki, hatchery rainbow trout,Oncorhyncus mykiss, and the plains killifish,Fundulus zebrinus, by counting the shed tips of rod outer segments ingested as phagosomes by pigment epithelial cells. After sunrise, phagosomes increased in all species, but fewer occurred in trout, and these were elevated from 3 to 9 hours after sunrise. Shedding occurred earlier in the light period and was more robust in killifish, with phagosomes elevated from 1.5 to 6 hours after sunset. The data suggest that both production of phagosomes by shedding and their subsequent disposal are slower at the lower temperatures experienced by trout. Otherwise, rod shedding produced under natural lighting is not appreciably different than that provoked by sudden onset of artificial light. 相似文献
179.
180.
Evidence for apostatic selection by wild passerines 总被引:2,自引:0,他引:2