Institutional experience of PTH evaluation on fine-needle washing after aspiration biopsy to locate hyperfunctioning parathyroid tissue

Assaying parathyroid hormone (PTH) in the washing liquid after fine-needle aspiration biopsy (FNAB) seems to be a valid approach to locate parathyroid tissue. PTH-FNAB was evaluated in 47 patients with a clinical picture of primary hyperparathyroidism (PHP) and ultrasonography (US) suggestive of parathyroid lesion. The patients were subdivided into two groups on the basis of the absence or presence of US thyroid alterations. The result of PTH-FNAB was compared with those of cytology, scintigraphy and, in 24 patients, surgical outcome. PTH-FNAB samples with a value higher than that recorded in the serum and higher than our institutional cut-off were deemed to be probable samples of parathyroid tissue. Cytology proved diagnostic for benign thyroid lesions, non-diagnostic for thyroid lesions, hyperplastic parathyroid tissue, undetermined or malignant thyroid lesions and other lesions in 45%, 30%, 17%, 4%, and 4% of cases, respectively. In 47% of cases, PTH-FNAB indicated that the sample had been taken in parathyroid tissue. In patients without US alterations, the diagnostic accuracy of PTH-FNAB was greater than that of scintigraphy. After surgery, comparison between the results of PTH-FNAB and scintigraphy, in terms of positive predictive value (PPV), revealed the superiority of PTH-FNAB; PPV was 94% for FNAB and 71% for scintigraphy, while sensitivity was 83% and 69%, respectively. PTH-FNAB evaluation after FNAB appears to be more diagnostic than cytology and scintigraphy. Of all the procedures used, PTH-FNAB appears to be the method of choice when the target is US suggestive and reachable. PTH-FNAB appears to be a useful method of guiding surgical intervention.     

专业英语互动式教学方法的探讨

针对专业英语教学模式较为单一的问题，结合自己作为这门课程的授课教师的切身体验，提出了一些互动模式的教学方法，增加课程的趣味性、实用性，对多媒体设备的充分利用，以及设置各种评估激励机制，激发学生的学习兴趣，提高教学效果。教学实践证明，学生比较满意互动式教学，在提高学生实际英语应用能力、口头表达能力、文献阅读能力等方面都产生了积极作用。     

输电线路OPGW光纤网络可靠性分析与设计

文章针对基于OPGW单芯光纤的输电线路监测系统网络的远距离、高带宽特点和低抗毁性的缺点,提出了一种基于多级级联技术的OPGW光纤网络的组网方法,给出了二级级联模式下系统失效的马尔科夫模型与概率计算公式,与单芯传输模式下的可靠性进行了分析对比,并分析了该模式下系统的抗毁性.采用多级级联技术的网络可靠性优于单芯传输模式,并且可靠性随着级联数的增加而提高.     

流动注射在线聚氨酯柱富集火焰原子吸收法测定矿样中的痕量金

本文用聚氨酯泡沫塑料作为柱材料，研究制定了在线预富集流动注射火焰原子吸收测定痕量金的新方法．实验溶液含金０．０２μｇ／ｍｌ，酸度为５％～１０％王水，以甲基异丁酮为洗脱液．当流速为１６ｍｌ／ｍｉｎ时，富集倍数为进样１ｍｉｎ富集５０倍．该方法选择性好，用于地质矿样中痕量金的测定，相对误差为１．１％．     

支持组合设计的一种可重构计算系统任务模型

针对现有可重构模型的不足,提出一种面向任务的支持组合设计的可重构计算模型系统.以生产者-消费者数据类型显式描述任务间通讯关系,并形式化描述任务的设计和运行时特征,提供组合设计规则,能够自动生成合成任务的各项属性,方便了应用系统的构建和性能评估.基于该模型可进行快速设计空间搜索,寻找最佳的系统设计方案.最后给出该模型的两种不同应用示例.     

Abnormal expression of centrosome protein (centrin) in spermatozoa of male human infertility

To study the relations between male infertility and centrosome protein (centrin) and the functions of centrin in spermatogenesis, the matured spermatozoa of 10 normal male people and 18 male infertility patients were stained by immunofluorescence labeling antibody against centrin. The results showed that two fluorescence signal dots appeared in the normal male spermatozoa and were located at the base of flagellum. They are proximal centriole and distal centriole. However, in some spermatozoa of the male infertility, centrin protein was located abnormally at the base of flagellum and its staining signals were spread, the normal proximal and distal centrioles were confused and could not be recognized separately. These results suggest that abnormality of centrosome protein may be related to male infertility. This discovery may be used as a marker of abnormal sperm and male infertility.     

Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation

We found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic (MRX) and syndromic (MRXS) forms of X-linked mental retardation (XLMR). Clinical features in affected males include mental retardation, microcephaly, short stature, spastic paraplegia and midline defects. PQBP1 has previously been implicated in the pathogenesis of polyglutamine expansion diseases. Our findings link this gene to XLMR and shed more light on the pathogenesis of this common disorder.     

一类时滞免疫反应系统动力学行为仿真

研究一类时滞免疫反应系统在机体清除靶细胞能力对浆细胞增长有影响的情形下的动力学行为,用时滞微分理论证明系统正平衡点的稳定性与时滞的关系,给出其稳定判定方法。在模型解基础上,用仿真方法研究部分参数变化对系统动力学行为的影响,给出了免疫系统呈现不同动力学行为的参数范围,实现免疫系统动态特性的仿真。结果表明,对于给定时滞,免疫反应系统的动力学行为不敏感地依赖于抗体清除抗原速率,而敏感地依赖于抗原繁殖系数。     

一种新型的非线性随机大系统自适应镇定方法

研究了一类具有严反馈形式并含有Wiener噪声扰动的非线性随机大系统,其互联项满足线性增长约束。利用微分几何的理论,应用Backstepping算法,基于Lyapunov稳定性理论,选择了适合这类组合非线性系统的状态观测器,设计了自适应输出反馈分散控制律和自适应律,使得闭环,互联的非线性随机大系统实现了概率意义下的全局稳定,仿真结果表明了控制算法的有效性。