基于两维压缩特征字分析的BIST性能分析

在现代电子系统的设计过程中,由于对系统的可靠性和可维护性要求越来越高,因此必须针对具体情况设计相应的内建自检(built-in self-testing,BIST)模块,从而保证系统能够进行准确的故障检测和故障定位与隔离.提出了一种基于两维压缩特征字分析的BIST方法,就其压缩原理和检测性能进行了详细分析.分析结果表明,通过时域和空域的两维压缩,可以用较短的特征字实现高故障覆盖率.该方法简单可靠,便于硬件实现.     

分段广义正交多项式算子法的非线性系统分析

首先对文献[7]提出的分段广义正交多项式算子(简记为PGOPO)的主要运算规则进行了概括和总结,特别是推导出了非线性函数的PGOPO递推计算公式;其次对一般非线性系统PGOPO算子解及解的收敛性问题进行了分析、研究,证明了PGOPO算子解将收敛于其精确解;最后采用PGOPO算子法对一类含时延的非线性系统进行了分析,并推导出便于使用的递推求解算法.给出的数值算例论证了该算法的有效性.     

Proton translocation by cytochrome c oxidase.

Cell respiration in mitochondria and some bacteria is catalysed by cytochrome c oxidase, which reduces O2 to water, coupled with translocation of four protons across the mitochondrial or bacterial membrane. The enzyme's catalytic cycle consists of a reductive phase, in which the oxidized enzyme receives electrons from cytochrome c, and an oxidative phase, in which the reduced enzyme is oxidized by O2. Previous studies indicated that proton translocation is coupled energetically only to the oxidative phase, but this has been challenged. Here, with the purified enzyme inlaid in liposomes, we report time-resolved measurements of membrane potential, which show that half of the electrical charges due to proton-pumping actually cross the membrane during reduction after a preceding oxidative phase. pH measurements confirm that proton translocation also occurs during reduction, but only when immediately preceded by an oxidative phase. We conclude that all the energy for proton translocation is conserved in the enzyme during its oxidation by O2. One half of it is utilized for proton-pumping during oxidation, but the other half is unlatched for this purpose only during re-reduction of the enzyme.     

Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities.

Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1--0.5 mM, but inhibited by higher concentrations.