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31.
M. K. Agarwal 《Cellular and molecular life sciences : CMLS》1976,32(4):531-533
Summary It is shown that cytosol preparations bound with various concentrations of a steroid are necessary to reveal physicochemically distinct, heterogeneous and polymorphic receptors present in the hormone specific target organ, that these cannot be fully appreciated in one-shot experiments at suboptimal steroids levels, and that they escape detection by equilibrium binding and Scatchard analysis alone. 相似文献
32.
A. K. Agarwal 《Cellular and molecular life sciences : CMLS》1976,32(12):1518-1520
Summary Trehalase from the salivary glands and the midgut ofSesamia inferens showed optimum activity at pH 5.8, and at temperatures of 50 and 60°C respectively. The increase in the incubation period, enzyme concentration, and substrate concentration respectively increased the end-product, the hydrolysis, and the rate of hydrolysis of the substrate. Dialysis did not affect, tryptophan accelerated, and other amino acids and end-product inhibited the enzyme activity.The author wishes to express his thanks to ProfessorR. Rakshpal for his constructive criticism, and to University Grants Commission, India, for awarding a Junior Research Fellowship. 相似文献
33.
Agarwal AK Arioglu E De Almeida S Akkoc N Taylor SI Bowcock AM Barnes RI Garg A 《Nature genetics》2002,31(1):21-23
Congenital generalized lipodystrophy is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. We report several different mutations of the gene (AGPAT2) encoding 1-acylglycerol-3-phosphate O-acyltransferase 2 in 20 affected individuals from 11 pedigrees of diverse ethnicities showing linkage to chromosome 9q34. The AGPAT2 enzyme catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in the biosynthesis of triacylglycerol and glycerophospholipids. AGPAT2 mRNA is highly expressed in adipose tissue. We conclude that mutations in AGPAT2 may cause congenital generalized lipodystrophy by inhibiting triacylglycerol synthesis and storage in adipocytes. 相似文献
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35.
Mechanical instability of the oxy-form of sickle haemoglobin 总被引:3,自引:0,他引:3
T Asakura P L Agarwal D A Relman J A McCray B Chance E Schwartz S Friedman B Lubin 《Nature》1973,244(5416):437-438
36.
Zusammenfassung Ein einfacher Weg zur selektiven Esterbildung mit der 5-Hydroxylgruppe von Thymidin wird beschrieben. Beispiele: Thymidin-5-phosphat, Thymidin-5-sulfat und Thymidin-5-trichloracetat. 相似文献
37.
J. A. Svoboda A. M. G. Nair Nita Agarwal W. E. Robbins 《Cellular and molecular life sciences : CMLS》1980,36(9):1029-1030
Summary Metabolic studies in which3H-sitosterol,3H-stigmasterol, and14C-desmosterol were administered by feeding and injection to the khapra beetle,Trogoderma granarium Everts, provided strong evidence that this insect is unable to dealkylate phytosterols and convert them to cholesterol. 相似文献
38.
Sameer Agarwal Jan Knoell Micha P. Krahll Hans-Joachim Knoelker 《复旦学报(自然科学版)》2005,44(5):699-700
We developed novel synthetic routes to heterocyclic ring systems by using transition metal-mediated or -catalyzed reactions. A Lewis acid-promoted addition of the propargyl Grignard reagent 2 to the Schiff base 1 followed by a silvermediated oxidative cyclization of the homopropargylamine 3 provided the aryl-substituted pyrrole 4. Combined with a cherroseleetive hydrogenation of the pyrrole ring, this rnethod has been applied to the total synthesis of the biologically active fused indolizidine alkaloids ( ± )-harmicine and ( ± )-crispine A. See Fig. 1. 相似文献
39.
Brush border sucrase and lactase activities are significantly elevated in alloxan-induced chronic diabetes and are restored to control levels after insulin treatment. Alkaline phosphatase and Mg-ATPase levels remain unchanged in diabetes, compared to a control group. Insulin treatment alone to control animals also led to enhanced activities of these enzymes. 相似文献
40.