连廊连接非对称双塔连体结构的连接参数研究

根据双塔连体结构柔性连接体系的3-DOF模型,以平稳白噪声为地震动激励,推导了塔楼位移的频响函数及功率谱密度函数,建立了结构振动能量表达式．以连廊两端的连接刚度和连接阻尼为研究参数,分别以单体塔楼结构和整体结构的振动能量最小为控制目标,采用数值分析方法探讨了连廊两端连接刚度和连接阻尼对结构振动的影响,得到了多种工况下的优化连接参数分布和在EICentro波、Taft波及人工波激励下的时程分析对比了减震效果．最后对某工程实例进行了位移反应功率谱密度分布分析和地震作用时程分析,对比了减震效果．结果表明连廊两端连接参数对底部塔楼结构动力反应具有交叉影响,塔楼结构不能同时达到最优减震效果,但可根据不同控制目标选取优化参数以取得较好减震效果．     

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing

Cancer is both a genetic and an epigenetic disease. Inactivation of tumour-suppressor genes by epigenetic changes is frequently observed in human cancers, particularly as a result of the modifications of histones and DNA methylation. It is therefore important to understand how these damaging changes might come about. By studying tumorigenesis in the Drosophila eye, here we identify two Polycomb group epigenetic silencers, Pipsqueak and Lola, that participate in this process. When coupled with overexpression of Delta, deregulation of the expression of Pipsqueak and Lola induces the formation of metastatic tumours. This phenotype depends on the histone-modifying enzymes Rpd3 (a histone deacetylase), Su(var)3-9 and E(z), as well as on the chromodomain protein Polycomb. Expression of the gene Retinoblastoma-family protein (Rbf) is downregulated in these tumours and, indeed, this downregulation is associated with DNA hypermethylation. Together, these results establish a mechanism that links the Notch-Delta pathway, epigenetic silencing pathways and cell-cycle control in the process of tumorigenesis.     

Parasite community of the golden cownose ray Rhinoptera steindachneri Evermann and Jenkins 1891 (Chondrichthyes: Myliobatidae), in Acapulco Bay,Guerrero, Mexico

The parasite community of the ray Rhinoptera steindachneri from Acapulco Bay was examined and quantified; analyses were based on the sex of the host and the date of sampling. A total of 171 specimens of R. steindachneri were examined during July–August of 2010, and May and July of 2012. Twenty-one species of parasites were found: three species of Monogenea; eight adult and one larval species of Cestoda; one larval species of Nematoda; five species of Copepoda; two species of Isopoda; and one species of Hirudinea. Cestodes had the greatest species richness (43% of the total species), followed by the copepods (24%). Two species of cestode, Glyphobothrium sp. and Rhinebothrium sp., were collected only from adult rays. At the component community level, species richness showed statistically significant variation between 13 and 16 species, which is similar to previous reports for other species of rays. The parasite component communities and infracommunities of R. steindachneri exhibited similar patterns: high species number and low numerical dominance by a particular species of parasite. The differences of body size of male vs. female rays, and a change in diet and feeding behaviour with the age of R. steindachneri, are likely important factors in the structuring of their parasite communities.     

基于模糊PI的天线伺服控制

针对天线伺服位置环路校正控制,在传统的PI控制上,加上模糊控制,实现位置环路多模态控制。在位置误差较大时,利用大比例控制,在位置误差小于一个阀值时,采用PI控制,在中间位置采用模糊控制。此种多模态控制,比单用PI控制,具有响应快,超调小,稳态误差小的优点。     

H3PNH＋H2CO类Wittig反应中四元环中间体的从头算研究

用从头算方法在ＭＰ２／６－３１Ｇ＊＊水平上优化出类Ｗｉｔｉｇ反应Ｈ３ＰＮＨ＋Ｈ２ＣＯ→Ｈ３ＰＯ＋Ｈ２ＣＮＨ中的中间稳定态、过渡态及复合态的几何构型。计算结果表明该反应是一个二步反应,在反应途径上存在一个四元环中间体。