Predation of adult razorback sucker and bonytail by striped bass in Lake Mohave, Arizona–Nevada

We report 2 separate records from sport-fish anglers in Lake Mohave, Arizona–Nevada, that document the presence of endangered razorback sucker Xyrauchen texanus and bonytail Gila elegans in stomach contents of large (13+ kg) nonnative striped bass Morone saxatilis. These records suggest that striped bass, since their first appearance in Lake Mohave nearly 3 decades ago, may have played a role in population declines of the other 2 species. Current native-fish stocking programs at Lake Mohave continue to face significant obstacles to achieving population recoveries because all life stages of repatriated individuals, including mature adults, are vulnerable to predation.     

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).     

Cellular maintenance of nuclear protein homeostasis

The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis. Over 15 degenerative diseases are associated with the aggregation of misfolded proteins specifically in the nucleus of cells. However, how the cell safeguards the nucleus from misfolded proteins is not entirely clear. In this review, we discuss what is currently known about the cellular mechanisms that maintain protein homeostasis in the nucleus and protect the nucleus from misfolded protein accumulation and aggregation. In particular, we focus on the chaperones found to localize to the nucleus during stress, the ubiquitin–proteasome components enriched in the nucleus, the signaling systems that might be present in the nucleus to coordinate folding and degradation, and the sites of misfolded protein deposition associated with the nucleus.     

Institutionalizing Insider Action Research Initiatives in Organizations: The Role of Learning Mechanisms

Managers face increasing pressure to find ways to surface, utilize and integrate bits and pieces of relevant knowledge that reside within and outside the organizational boundaries to address emerging challenges. Grappling with this issue and based on a longitudinal study with a biopharma company, this paper offers the notion that insider action research coupled with the design and management of learning mechanism tapestry can enhance continuous organizational learning and improvement. The institutionalization of the learning mechanism tapestry provided new capability that enhanced the organization’s agility as well as a way to stabilize insider action research role and practices.     

Some comments on the initialization of exponential smoothing

It is shown that the traditional choice for the initial smoothed statistics in general exponential smoothing leads to the same forecasts as the equivalent ARIMA model, provided that one uses zero starting values for the initial shocks. In addition, an initialization which uses ‘backforecasts’ as initial smoothed statistics is considered, and its relationship to unconditional least squares is explored.     

Length of the year in pre-epicyclic planetary theory

An estimate is made of the length of the year implied in the pre-epicyclic planetary theory of the Pañcasiddhntik. It is shown that this could be the same as the year-length of the corresponding Babylonian theory.     

Dynein mutations impair autophagic clearance of aggregate-prone proteins

Mutations that affect the dynein motor machinery are sufficient to cause motor neuron disease. It is not known why there are aggregates or inclusions in affected tissues in mice with such mutations and in most forms of human motor neuron disease. Here we identify a new mechanism of inclusion formation by showing that decreased dynein function impairs autophagic clearance of aggregate-prone proteins. We show that mutations of the dynein machinery enhanced the toxicity of the mutation that causes Huntington disease in fly and mouse models. Furthermore, loss of dynein function resulted in premature aggregate formation by mutant huntingtin and increased levels of the autophagosome marker LC3-II in both cell culture and mouse models, compatible with impaired autophagosome-lysosome fusion.     

Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH

The control by Na+/H+ antiporters of sodium/proton concentration and cell volume is crucial for the viability of all cells. Adaptation to high salinity and/or extreme pH in plants and bacteria or in human heart muscles requires the action of Na+/H+ antiporters. Their activity is tightly controlled by pH. Here we present the crystal structure of pH-downregulated NhaA, the main antiporter of Escherichia coli and many enterobacteria. A negatively charged ion funnel opens to the cytoplasm and ends in the middle of the membrane at the putative ion-binding site. There, a unique assembly of two pairs of short helices connected by crossed, extended chains creates a balanced electrostatic environment. We propose that the binding of charged substrates causes an electric imbalance, inducing movements, that permit a rapid alternating-access mechanism. This ion-exchange machinery is regulated by a conformational change elicited by a pH signal perceived at the entry to the cytoplasmic funnel.     

The motion of Mars in Egyptian planetary tables

B. L. van der Waerden's thesis, that the motion of Mars in the Stobart Tables has been computed by linear methods based on the assumption of a piece-wise constant velocity, is discussed in this paper, and some further evidence presented.