Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster

We investigated the pathophysiology of neurofibromatosis-1 (NF1) in Drosophila melanogaster by inactivation or overexpression of the NF1 gene. NF1 gene mutants had shortened life spans and increased vulnerability to heat and oxidative stress in association with reduced mitochondrial respiration and elevated reactive oxygen species (ROS) production. Flies overexpressing NF1 had increased life spans, improved reproductive fitness, increased resistance to oxidative and heat stress in association with increased mitochondrial respiration and a 60% reduction in ROS production. These phenotypic effects proved to be modulated by the adenylyl cyclase/cyclic AMP (cAMP)/protein kinase A pathway, not the Ras/Raf pathway. Treatment of wild-type D. melanogaster with cAMP analogs increased their life span, and treatment of NF1 mutants with metalloporphyrin catalytic antioxidant compounds restored their life span. Thus, neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants.     

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin. These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans.     

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.     

Low slip rates and long-term preservation of geomorphic features in Central Asia

In order to understand the dynamics of the India Asia collision zone, it is important to know the strain distribution in Central Asia, whose determination relies on the slip rates for active faults. Many previous slip-rate estimates of faults in Central Asia were based on the assumption that offset landforms are younger than the Last Glacial Maximum (approximately 20 kyr ago). In contrast, here we present surface exposure ages of 40 to 170 kyr, obtained using cosmogenic nuclide dating, for a series of terraces near a thrust at the northern margin of the Tibetan Plateau. Combined with the tectonic offset, the ages imply a long-term slip rate of only about 0.35 mm x yr(-1) for the active thrust, an order of magnitude lower than rates obtained from the assumption that the terraces formed after the Last Glacial Maximum. Our data demonstrate that the preservation potential of geomorphic features in Central Asia is higher than commonly assumed.     

Diatom floristics and succession in a peat bog near Lily Lake, Summit County, Utah

Diatoms from core samples obtained from the edge of Lily Lake, Summit County, Utah, were studied. Populations from each 15 cm of the core and niche metrics of the important species were analyzed. This study demonstrates four periods of history in the lake as mirrored by the diatom populations. The first period was mesotrophic and alkaline. This graded into an acidic, dystrophic period which in turn yielded again to a mesotrophic alkaline period. The most recent period can be characterized by a return to dystrophy.     

Environmental interaction in summer algal communities of Utah Lake

Utah Lake is a shallow eutrophic lake in central Utah. It is characterized by high nutrient and silt loads and by large algal blooms in late summer and early fall. Phytoplankton samples and environmental data were taken from June through August 1974. Phytoplankton species were identified and then quantified in a Palmer counting cell. Environmental continuum theory was employed to describe algal succession, and regression analysis was used to discover interactions between algal communities and the environment. Phytoplankton communities in June were characterized by high species diversity. As the lake environment became stressed in late summer due to higher turbidity, nutrient levels, pH, and available inorganic carbon species diversity decreased. By August, the phytoplankton flora was composed essentially of only two species, Ceratium hirundinella and Aphanizomenon flos - aquae.     

Subaerial algae of Navajo National Monument, Arizona

Samples from soils and other xeric substrates in Navajo National Monument, Navajo County, Arizona, were collected in 1978. After being moistened with deionized water for three days, these samples were analyzed for algae. Thirty algal taxa were identified. Five species of filamentous Cyanophyta comprised the majority of the biomass. Diatoms were ubiquitous in the soils although low in density. Diatom floras were very similar throughout the monument. Well-developed algal crusts were common in sites where grazing and excessive litter were absent.     

Influence of cryptogamic crusts on moisture relationships of soils in Navajo National Monument, Arizona

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New records and comprehensive list of the algal taxa of Utah Lake, Utah, USA

Utah Lake is a slightly saline ecosystem containing more than 700 algal taxa. During the past decade a total of 106 algal taxa has been found that has not previously been reported in this water. These new records are reported herein, together with a comprehensive listing of all algal taxa reported from Utah Lake to date.