Chromosomal effects of adeno-associated virus vector integration.

Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).     

高校领导干部代际转移中作风建设的若干思考

本文针对高校领导干部代际转移中作风建设的实际,论述了加强新一代高校领导干部作风建设的基本要点,并据以提出抓好这项工作的三种途径.     

大学扩招与质量问题刍议

为了进一步实施科教兴国战略,提高全民族的整体素质,尽快培养大批适应现代化需要的高素质的劳动者和各类专门人才,1999年6月,党中央、国务院作出了扩大高等学校招生规模的重大决策,高等教育以前所未有的规模和速度发展.……     

Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.

During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is accomplished through spontaneous folding to a thermodynamically stable and active native state. However, in the extracellular bacterial alpha-lytic protease (alphaLP) these two processes have become decoupled. The native state of alphaLP is thermodynamically unstable, and when denatured, requires millennia (t1/2 approximately 1,800 years) to refold. Folding is made possible by an attached folding catalyst, the pro-region, which is degraded on completion of folding, leaving alphaLP trapped in its native state by a large kinetic unfolding barrier (t1/2 approximately 1.2 years). alphaLP faces two very different folding landscapes: one in the presence of the pro-region controlling folding, and one in its absence restricting unfolding. Here we demonstrate that this separation of folding and unfolding pathways has removed constraints placed on the folding of thermodynamically stable proteins, and allowed the evolution of a native state having markedly reduced dynamic fluctuations. This, in turn, has led to a significant extension of the functional lifetime of alphaLP by the optimal suppression of proteolytic sensitivity.     

TV跟踪系统光电轴一致性研究

本文论述复合制导系统 ＴＶ光电设备光电轴一致性问题，并给出新的处理方法。研究结果表明：本方法具有较高的精度与应用价值。     

教育投资成本与收益的因素分析

高等教育投资的成本与收益是学校管理者、政府部门、学生和家长以及研究人员等有关各方都非常关心的重要信息.研究其影响因素对于探讨降低成本、提高收益的途径具有重要的意义.而其影响因素是多方面的,这里就几个主要方面进行了分析.     

高校合理布局与推进地区协调发展和城镇化

高等教育的合理布局直接关系到人力资源的开发、配置和有效利用.20世纪90年代,我国高等教育经过深化改革和管理体制的调整,得到大发展的机遇.目前,中央和各省、市、自治区教育行政部门都在考虑高等教育的发展、结构调整及合理布局问题.本报告试图从高等院校的合理布局出发,借鉴国外高等教育的布局及特点,根据我国的实际情况,提出建议,以更好地推动国家及各地区建设事业的协调发展,促进城镇化战略的实施. 　　……     

Comparative study of the karyotypes of two Egyptian species of bats,Taphozous perforatus andTaphozous nudiventris (Chiroptera: Mammalia)

A detailed karyotypic analysis of two Egyptian species of bats,Taphozous perforatus andTaphozous nudiventris, was made on the basis of conventional data and G-band patterns. No detectable karyotypic difference was found between the two species (2n=42, F.N. 64). By comparison of G-band patterns, some differences between the two species were seen in the corresponding autosomal pairs. These results are reported for the first time in Egypt.     

芦岭矿采空区煤炭自燃发火与开采技术关系的试验研究

采用了包括多点热电偶测定采空区遗煤温度、应用六氟化硫气体示踪和测定漏风压差等综合技术手段研究分析了漏风分布规律。结果发现,遗煤温度变化受漏风温度和漏风强度影响较大;停采线漏风的量及漏风时间受主要进、回风道的布置以及采掘接替安排的影响。由于采用无煤柱开采技术,三个相邻阶段的采空区之间连通,存在漏风,最后又从开采技术上提出了防火措施。     

高原鼠兔体重生长动态数学模型之再探讨

本文用麦夸算法构造高原鼠兔体重生长的Logistic和Compertz曲线模型,其结果表明:Logistic曲线比Gompertz曲线更优化,Logistic模型比逻辑斯谛-指要饱和模型的精确度更高.