Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.

Interleukin-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1-3). IL-2 is, however, not the sole T-cell growth factor, nor does it act exclusively on T cells, also promoting growth of NK cells and differentiation of B cells. A role for IL-2 in T-cell development has been postulated but remains controversial. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.     

高含固量聚苯乙烯－聚丙烯酸酯复合乳胶的合成及表征

本文采用种子乳液聚合技术，合成聚苯乙烯－聚丙烯酸酯复合乳液，用ＴＥＭ电镜观察其乳液的形态，用ＧＰＣ方法测定了乳胶聚合物的化学组成。     

Discovering Frequent Subtrees from XML Data Using Neural Networks

By rapid progress of network and storage technologies, a huge amount of electronic data such as Web pages and XML has been available on Internet. In this paper, we study a data-mining problem of discovering frequent ordered sub-trees in a large collection of XML data, where both of the patterns and the data are modeled by labeled ordered trees. We present an efficient algorithm of Ordered Subtree Miner （OSTMiner） based on two- layer neural networks with Hebb rule, that computes all ordered sub-trees appearing in a collection of XML trees with frequent above a user-specified threshold using a special structure EM-tree. In this algo- rithm, EM-tree is used as an extended merging tree to supply scheme information for efficient pruning and mining frequent sub-trees. Experiments results showed that OSTMiner has good response time and scales well.     

The Huntington's disease candidate region exhibits many different haplotypes.

Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.     

30MnNbXt钢组合匹配接头性能的研究

本文为新钢种30MnNbXt设计了一种独特的组合匹配接头,研究了底层奥氏体焊条的合金系统及填充层结构钢焊条的强度对抗裂性的影响,探讨了底层高组配、填充层低组配的组合匹配焊缝特征区的组织特点及接头的力学性能。在西德WS1.7—2.0/3.5型综采支架立柱中应用表明,组合匹配接头可使30MnNbXt钢在室温下焊接时不产生裂纹;接头在焊后状态的使用性能完全符合产品技术条件要求。     

投掷球出手速度测试仪的进一步开发

通过对仪器测速过程的进一步分析,提出了一种新的数据处理方法。此方法可消除原方法所引入的随机误差,并能得到投掷球出手速度的方向和出手高度。采用新方法后,可使仪器结构进一步简化,能降低传感器制造成本30％。     

Hydrobiologische Anstalt Plön der Max-Planck-Gesellschaft zur Förderung der Wissenschaften

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