The Huntington's disease candidate region exhibits many different haplotypes.

Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.     

Hydrobiologische Anstalt Plön der Max-Planck-Gesellschaft zur Förderung der Wissenschaften

Ohne Zusammenfassung     

Réactions cytologiques à l'introduction pulmonaire expérimentale de particules de silicium métalloïdique

Summary By means of intratracheal injection, particles of metalloid silicium about five microns in size are introduced into the lungs of guinea pigs, and the secondary parenchymatous reactions are studied from 10 minutes to 105 days. In the dust cells, the silicium is progressively broken up into very small particles of less than 1 micron in size. The cells do not show degeneration or mummification as the ordinary silica cells (Mavrogordato) do.     

概化理论在语言测试新进展中的应用

概化理论是一种发展较晚但功能全面的现代测试理论，能有效地设计、分析和评估测试项目。直到上个世纪八九十年代，Robert Brennan等人开发了GENOVA等一系列应用软件后，概化理论才在心理和教育测量领域的研究中逐渐受到重视，此后，运用概化理论研究实际问题的项目也逐渐多了起来。概化理论与项目反应理论属于不同的理论范畴，它们的基本假设也有很大的差别。     

La structure de certaines terminaisons nerveuses montre des variations cycliques

Summary All sensory endings of the trigeminal nerve in the dura mater of the rat are formed by a small swelling, from which continues themetaterminal apparatus, fine filaments at the limit of visibility. Periodically the fine granules at the extremity of the filaments swell, whereas the fibrils themselves disappear, leaving a small, round, argentophil mass. Later the filaments reappear, then redeposit their debris, which persists for a time.Thus the metaterminal apparatus manifests cyclic variations, which recall the transitory existence of collaterals observed duringin vivo orin vitro development of nerve fibres.