Galileo and the problem of concentric circles

In 1892, Eliakim Hastings Moore accepted the task of building a mathematics department at the University of Chicago. Working in close conjuction with the other original department members, Oskar Bolza and Heinrich Maschke, Moore established a stimulating mathematical environment not only at the University of Chicago, but also in the Midwest region and in the United States in general. In 1893, he helped organize an international congress of mathematicians. He followed this in 1896 with the organization of the Midwest Section of the New York City-based American Mathematical Society. He became the first editor-in-chief of the Society's Transactions in 1899, and rose to the presidency of the Society in 1901.     

Sir William Hamilton (1730–1803): His work and influence in geology

In the formative period of London's scientific instrument industry membership of a guild was a necessary step towards owning a business in the City. Through the guilds' formal system of apprenticeship, boys received first-class training in a skilled trade, and learned essential marketing and managerial techniques. By analysing the guilds' records of apprenticeship and subsequent guild life it is possible to determine chains of masters and apprentices by which the knowledge passed from generation to generation. At the same time, dates can be established for the training and subsequent working life of many known makers. The chains of knowledge reveal new and often important masters who were previously unknown because, by chance, their instruments or advertisements have not survived to the present day. Two guilds have been used to illustrate the chains: Broderers' Company and Joiners' Company.     

Galileo and the problem of infinity

During the period before the Greek revolution of 1821, and especially during the years between 1750 and 1821, there were two ways in which European scientific thought was propagated in Greece. The first is traditional. It comes from ancient Greece and, through Byzantium, reaches the period before the Greek revolution. It makes known the thought of Aristotle, Democrititus, and others on ‘natural philosophy’. The second way comes from Europe. The Greek scholars of the period before the Greek revolution, and especially at the end of the eighteenth century, tried to bring to and propagate in Greece the spirit ofthe European Enlightenment, They tried to make known to the Greek people the scientific achievements of Newton, Descartes, Lavoisier, and Laplace. Scientific knowledge is an important weapon against superstition, and Greek students had to learn about science to become free persons in an independent Greek state.     

Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy

Cyclase-associated proteins are highly conserved proteins that have a role in the regulation of actin dynamics. Higher eukaryotes have two isoforms, CAP1 and CAP2. To study the in vivo function of CAP2, we generated mice in which the CAP2 gene was inactivated by a gene-trap approach. Mutant mice showed a decrease in body weight and had a decreased survival rate. Further, they developed a severe cardiac defect marked by dilated cardiomyopathy (DCM) associated with drastic reduction in basal heart rate and prolongations in atrial and ventricular conduction times. Moreover, CAP2-deficient myofibrils exhibited reduced cooperativity of calcium-regulated force development. At the microscopic level, we observed disarrayed sarcomeres with development of fibrosis. We analyzed CAP2’s role in actin assembly and found that it sequesters G-actin and efficiently fragments filaments. This activity resides completely in its WASP homology domain. Thus CAP2 is an essential component of the myocardial sarcomere and is essential for physiological functioning of the cardiac system, and a deficiency leads to DCM and various cardiac defects.