Effects of some oligopeptides,consisting of aromatic amino acids,on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac)

Summary L-Phe-L-Tyr and L-Lys-L-Phe-L-Tyr showed a marked inhibitory effect (not chloride-dependent) on the excitability of an identifiable giant neurone (the TAN) of Achatina fulica Férussac, while L-Tyr-L-phe, L-Tyr-L-Tyr, L-Phe-L-Phe, L-Lys-L-Phe and Z-L-Phe-L-Tyr (Z-: carbobenzoxy) had no effect.Authors wish to thank Dr Atsuo Inoue of Daiichi Pharmaceutical Co. for his helpful advice, and Miss Hiroko Tamura for her technical assistance.     

Additive and synergistic inhibition of mammalian microsomal enzyme functions by piperonyl butoxide,safrole and other methylenedioxyphenyl derivatives

Zusammenfassung Piperonylbutoxyd, Methylendioxylanilin, Methyleugenol, Safranol und Vanillylamin bewirken eine additive Hemmung der Funktion mikrosomaler Enzyme in Mäusen, wenn sie zusammen in Dosen verabreicht werden, die einzeln inaktiv sind. Piperonylbutoxyd und Safranol induzieren synergistisch die Hemmung von Aminopyrenedemethylase-Aktivität. Es erfolgte keine synergistische Hemmung nach kombinierter Behandlung mit Pib. und hohen Dosen der strukturell verwandten, aber inaktiven Piperonylsäure.

---

---

Supported by N.I.H. Grants No. C-6516 and No. Fr-05526.

---

We thank Mrs.M. Sengupta and Mr.E. Greene for their technical assistance.