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51.
论述了辨证认识与处理好人才的“留”与“流”的关系,指出了只有做好人才管理工作,慎重地考虑人才的留用,才能使企业长期、持续、健康、稳定地发展。 相似文献
52.
强直电流伸展弧CVD硬质合金金刚石涂层工具 总被引:1,自引:0,他引:1
采用自行研制的强电流直流扩展电弧设备对酸浸和渗硼预处理的YG6刀片进行了金刚石薄膜涂层沉积,并对放于不同位置的沉积刀片表面涂层的激光Raman谱和SEM形貌进行了分析、研究。结果表明:渗硼预处理工艺优于酸浸预处理工艺;在渗硼处理的GY6刀片上,沉积的金刚石薄膜涂层具有大面积、均匀性好和质量高的特点。 相似文献
53.
Obese postmenopausal female volunteers were given timed daily oral dosages of bromocriptine, and tested for reduction of body fat stores. This dopamine agonist has been shown to reset circadian rhythms that are altered in obese animals and to reduce body fat levels in several animal models. The participants were instructed not to alter their existing exercise and eating behavior during treatment. Skinfold measurements were taken on 33 subjects as indices of body fat. The measurements (e.g., suprailiac) were reduced after six weeks by about 25%, which represents a reduction of 11.7% of the total body fat. These dramatic decreases in body fat, which are equivalent to that produced by severe caloric restriction, were accompanied by more modest reductions of body weight (2.5%), indicating a possible conservation of protein that is usually lost as a consequence of such caloric restriction. The effects of bromocriptine treatment on body fat and hyperglycemia were also examined in non-insulin dependent diabetics being treated with oral hypoglycemics (7 subjects) or insulin (7 subjects). Total body fat was reduced by 10.7% and 5.1% in diabetics on oral hypoglycemics and insulin, respectively, without any significant reductions in body weight. Hyperglycemia was reduced in most of the 15 diabetic subjects treated leading to euglycemia and even cessation of hypoglycemic drugs in 3 of the 7 subjects during 4-8 weeks of bromocriptine treatment. These findings support the hypothesis that obesity and type II diabetes may be treated effectively with bromocriptine when administered at the proper times and dosages. 相似文献
54.
Urinary excretion of glycated albumin was quantitated in genetically hyperglycemic mice (C57BL-Ks-J, db/db mice), a model for non-insulin-dependent diabetes mellitus, and compared with their non-diabetic littermates. The data indicated a preferential excretion of glycated albumin in non-diabetic mice. This phenomenon of 'editing' of glycated albumin is decreased significantly in diabetic mice. Quantitative measurements of overall excretion of glycated albumin suggested that the loss of editing in diabetic mice is due to the dilution of glycated albumin by the unmodified albumin which is excreted in large amounts in diabetic mice. Therefore, the loss of editing observed in this model resembled the one we characterized in insulin-dependent diabetic humans and a streptozotocin-diabetic rat model. 相似文献
55.
一般普通高校科研中的定位 总被引:1,自引:0,他引:1
普通高校“层次提升“不仅意味着要求学校规模和学科门类的扩大,更重要的是教学、科研质量的实质性提高.这个发展过程要求这类高校不仅要把教学改革提到高等教育改革的核心地位,更要根据社会发展的需要和自身的特点积极开展多种形式的科学研究活动,将科学研究引入教学过程,使教学与科研紧密结合、产学研结合,推动高校快速健康发展,从而达到提高教学质量和学校的学术水平目的. 相似文献
56.
微分代数控制问题的数值计算方法 总被引:3,自引:0,他引:3
费景高 《系统工程与电子技术》1992,(6)
描述许多轨道控制问题的方程通常构成非线性半显式的微分代数系统。本文提出一些数值方法来计算这些控制问题的控制规律。对于一个模型问题,本文进行了稳定性分析,并且给出了稳定性区域。文中估计了这些方法的全局误差,它们给出控制误差与计算步长的关系。 相似文献
57.
Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. 总被引:32,自引:0,他引:32
Human cytomegalovirus (HCMV, a betaherpes virus) is the cause of serious disease in immunologically compromised individuals, including those with acquired immunodeficiency syndrome. One of the compounds used in the chemotherapy of HCMV infections is the nucleoside analogue 9-(1,3-dihydroxy-2-propoxymethyl)-guanine (ganciclovir). The mechanism of action of this drug is dependent on the formation of the nucleoside triphosphate, which is a strong inhibitor of the viral DNA polymerase. Thymidine kinase, which is encoded by many of the herpesviruses, catalyses the initial phosphorylation of ganciclovir. But there is no evidence for the coding of this enzyme by HCMV, and DNA sequence analysis of the HCMV genome has shown that there is no open reading frame characteristic of a herpesvirus thymidine kinase. Here we present biochemical and immunological evidence that the HCMV UL97 open reading frame codes for a protein capable of phosphorylating ganciclovir. This protein seems to be responsible for the selectivity of ganciclovir and will be useful tool in the understanding and refinement of the antiviral activity of new selective anti-HCMV compounds. 相似文献
58.
A. F. McDonagh Y. -M. Pu D. A. Lightner 《Cellular and molecular life sciences : CMLS》1992,48(3):246-248
The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics. This sign inversion, which is completely reversed by removal of the anesthetic, reflects a pronounced conformational change of the bound ligand; probably a complete inversion of chirality. The observation suggests that association of volatile anesthetics with proteins can markedly alter the internal topography of receptor sites and potentially influence the stereoselectivity of ligand binding. 相似文献
59.
60.