Expression of human clotting factor Ⅸ mediated by recom- binant lentiviral vector in cultured cells and hemophilia B mice

Hemophilia B, a serious bleeding disorder, is an inherited X chromosome-linked disease for the deficiency or inactivity of human clotting factor Ⅸ (hFⅨ). Though factor substitution therapy has greatly improved the lives of hemophiliac patients, there are still limitations to the current treatment, which have triggered interest in alternative treatments by gene therapy[1]. Based on preclinical studies in rabbits[2], our lab had first initiated an ex vivo gene therapy clinical trial whereby a…     

爱若琴弦

66岁的她静静地站着。“这是我在这个世界里的最后一天了,等到今天过去,我会永远的离开这个世界。”她这样想着,并留恋地看着自己的影子、自己亲手一砖一瓦建起来的城邦和曾经每天陪着自己练功的那150个女仆。“不要再想了,都已经决定了的事。”她勉强地给自己一个笑容。“直的决定了吗?”他问。     

Carbon sequestration within millet phytoliths from dry-farming of crops in China

Phytoliths are noncrystalline minerals that form inside cells and cell walls of different parts of plants. Organic carbon in living cells can be occluded in phytoliths during plant growth. It has been documented that the occluded carbon within phytoliths is an important long-term terrestrial carbon reservoir that has a major role in the global carbon cycle. Common millet and foxtail millet have become typical dry-farming crops in China since the Neolithic Age. The study of carbon conservation within phytoliths in these crops could provide insights into anthropogenic influences on the carbon cycle. In this study, we analyzed the carbon content in phytoliths of common millet and foxtail millet. The results indicated that (1) common millet and foxtail millet contained 0.136% ± 0.070% and 0.129% ± 0.085% phytolith-occluded carbon (PhytOC) on a dry mass basis, respectively; (2) based on the mean annual production of common millet and foxtail millet in the last 10 years, the phytolith occluded carbon accumulation rate of common millet and foxtail millet was approximately 0.023 ± 0.015 and 0.020 ± 0.010 t CO 2 ha 1 a 1 , respectively; (3) assuming a similar phytolith occluded carbon accumulation rate as for common millet (the highest accumulation rate was 0.038 t CO 2 ha 1 a 1 ), this could result in the sequestration of 2.37 × 10 6 t CO 2 per year for the 62.4 × 10 6 ha dry-farming crops in China. Although there was a decline in the annual production rate and planting area of foxtail millet during 1949 to 2008, the total phytolith carbon sequestration rate was 7×10 6 t CO 2 within the 60-year period. However, phytolith occluded carbon has not yet been fully considered as a global carbon sink. Also, this carbon fraction is probably one of the best candidates for the missing carbon sink.     

一类解析函数的Fekete-Szeg不等式

引入了一个新的解析函数类Bθ(λ,α,ρ),讨论了此函数类的Fekete-Szeg不等式,得到了准确的结果,推广了相关结果.     

关于Bazilevi(c)函数的一个子类的Fekete-Szeg(o)不等式

研究了正规化解析函数H的子类B(λ,α,A,B,σ)的Fekete-Szeg(o)不等式,对于任意的f(z)=z+a2,+a3z3+…∈B(λ,α,A,B,σ)及任意的复参数u,应用解析函数的基本不等式和分析技巧,得到了M1(α,λ,A,B)的精确上界.     

某类与In算子有关的解析函数的Fekete-Szeg¨(o)不等式

令Inf(z)＝[z/(1－z)λ＋1](－1)*f(z)＝z＋zk＋1(n∈N0＝0,1,2,…).引入了一个与算子In有关的解析函数类H(α,n;A,B),利用函数的极值和单调性,讨论了此函数类的2(2)不等式(μ为复数),推广了一些已有的结果.     

关于非-Bazilevicˇ函数的几个Fekete-Szeg不等式

引入一个解析函数类N(α,μ,A,B),利用函数的极值和单调性,讨论此函数类的|a₃－μa²₂|不等式(μ为复数),推广了一些已有的结果.     

异丁基硼酸的超声辐射合成

在超声条件下,以卤代烃、金属镁粉、硼酸酯为原料合成了异丁基硼酸.反应的最佳条件为:以碘及二溴乙烷做催化剂,超声波功率为175 W,反应时间为15 min,反应温度为40℃.     

基于差分GPS的局部区域无人车路径跟踪算法

为确保无人车在弯曲度变化较大的路径上运行的平稳性及速度变化的连续性,基于差分GPS定位导航系统,综合考虑前视距离、速度和弯曲度之间的关系,提出了一种改进的Pure Pursuit算法。首先,通过差分GPS对局部区域内的路径信息进行采集,基于NMEA协议对GPS接收机输出数据进行坐标转换;其次,结合车辆运动学自行车模型与Pure Pursuit改进算法进行路径跟踪。试验结果表明,无人车以30 km/h的最高车速与5 km/h的最低车速跟踪既定路径时,最大横向跟踪偏差相比既有算法降低55. 4%,平均横向跟踪误差相比既有算法降低23. 98%,达到了较好的跟踪效果。