A new anti-hypoxia functional agent ―a Schizophyllum commune fermented broth and its possible biochemical mechanisms

In order to overcome hypoxia induced sickness,a stable source of anti-hypoxia functional agents, Schizophyllum commune fermented broth has been developed in this study. Animal experiments were conducted to examine its anti-hypoxia activities and possible mechanisms involved. The acute hypoxic experiment showed that Schizophyllum commune fermented broth could significantly prolong the survival time of mice. The underlying mechanisms were associated with improved energy metabolism based on a study carried out in rats exposed to a low pressure chamber simulating the low pressure environment of 8 000 m altitude. It was concluded that the Schizophyllum commune fermented broth was an effective anti-hypoxia functional agent and could be greatly bene- ficial to those living and working at high altitudes,such as people who reside in the reconstruction regions of Yushu.     

Moldability Evaluation for Molded Parts Based on Fuzzy Reasoning

Moldability evaluation for molded parts,which is the basis of concurrent design,is a key design stage in injection molding design.By moldability evaluation the design problems can be found timely and an optimum plastic part design achieved.In this paper,a systematic methodology for moldability evaluation based on fuzzy logic is proposed.Firstly,fuzzy set modeling for six key design attributes of molded parts is carried out respectively.Secondly,on the basis of this,the relationship between fuzzy sets for design attributes and fuzzy sets for moldability is established by fuzzy rules that are based on domain experts‘ experience and knowledge.At last the integral moldability for molded parts is obtained through fuzzy reasoning.The neural network based fuzzy reasoning approach presented in this paper can improve fuzzy reasoning efficiency greatly,especially for system having a large number of rules and complicated membership functions.An example for moldability evaluation is given to show the feasibility of this proposed methodology.     

螺旋线对斜拉索涡激振动特性影响的试验研究

为研究不同参数的螺旋线对斜拉索涡激振动特性和气动力的影响规律,进行了针对表面无螺旋线斜拉索和缠绕不同参数螺旋线斜拉索的节段模型风洞试验,螺旋线参数包括根数、直径和缠绕间距. 结果表明：斜拉索表面缠绕1根螺旋线的涡激振动振幅远大于2根或3根螺旋线;在亚临界雷诺数区,缠绕螺旋线斜拉索的平均气动阻力系数均小于无螺旋线斜拉索,最多可减小10.9%;缠绕2根螺旋线的斜拉索平均阻力系数整体比3根螺旋线小. 斜拉索表面缠绕间距s=8D（D为斜拉索直径）的2根螺旋线时,缠绕直径d<15 mm螺旋线的斜拉索涡激振动现象明显;d ≥15 mm的螺旋线可显著降低斜拉索涡激振动响应幅值,其脉动升力系数相较于无螺旋线斜拉索有明显降低,证明缠绕大直径螺旋线对涡激振动响应控制的有效性. 螺旋线的缠绕间距对斜拉索涡激振动的影响与螺旋线直径有关,当螺旋线直径较小时,缠绕间距对涡激振动的影响并不明显;当螺旋线直径较大时,间距的大小直接影响涡激振动的抑制效果.     

Anti-TOSO antibody treatment promotes T cell activation-induced cell death （AICD） in vitro and in vivo

T cell activation-induced cell death （AICD）, that involves the induction of Fas-mediated apoptosis, is very important for the maintenance of immune homeosta- sis. TOSO was firstly described as an inhibitor of Fas- mediated apoptosis and overexpressed in chronic lymphocytic leukemia. Recently, TOSO was identified as IgM FcR. In this study, we produced anti-TOSO monoclonal antibody （mAb） that could block the binding of IgM to TOSO and found that T cell apoptosis is negatively cor- related with TOSO expression during T cell activation. Treatment of activated T cells with anti-TOSO blocking mAb promoted T cell AICD in in vitro AICD model, and treatment of xenogeneic-GVHD mice with the antibody also increased the sensitivity of activated T cells to Fas- induced apoptosis, which was accompanied by reduction of c-FLIPL expression and up-regulation of AP-1 complex. In summary, our data indicate the anti-apoptotic effect of TOSO in T cell AICD and open up new therapeutic prospects for the treatment of hematologic malignancies and immune disorders.