Interaction between integrin αIIbβ3 and synthesized cyclic hexapeptide containing RGD

The RGD sequence generally exists in the extracellular matrix proteins and can be recognized by many integrin proteins. The binding ability of immobilized biotinylated cyclic hexapeptide [cyclo(-Arg-Gly-Asp-D-Phe-Lys-Gly-)] containing RGD to integrin α_αbβ₃ was tested by the methods of ELISA and SPR. Results showed that a spacer of 1.48–2.2 nm between the peptide and the biotin residue was long enough to send the RGD sequence into the binding center embccedded within α_IIbβ₃, and the equilibrium dissociation constant was 1.1 μm. The work provides an ideal model system for the research of cell adhesion on solid surfaces.     

Photo-physical Characterisation of Novel Organic Dye-doped Solid-state Laser Materials

1 Results The development of tuneable solid-state organic dye lasers is a subject of considerable interest and research activity.Compared to conventional liquid dye lasers they have the advantage of being free of solvent handling,having small size,and being easy to operate.For high-performance solid-state dye lasers highly photo-stable dyes with low quantum yield of triplet formation and low triplet-triplet absorption cross-section in the lasing wavelength region are required.For solid state dye lasers organic molecules have been incorporated in inorganic glasses (mainly sol-gel glasses),in organic polymer matrices,and into hybrid compositions of inorganic-organic hosts.Here samples of the BODIPY dye (dipyrromethene-BF2 dye) PM597 incorporated in copolymers resembling inorganic-organic hybrid matrices are characterized by optical spectroscopic methods towards their application as solid-state laser rods.The inorganic function is entered by the constituent 3-(trimethoxysilyl)propyl methacrylate (TMSPMA).The organic constituents are monomers with one polymerizable group [methyl methacrylate (MMA),or 2-hydroxyethyl methacrylate (HEMA)],two [ethylene glycol dimethacrylate (EGDMA)],three [pentaerythriol triacrylate (PETA)],and four [pentaerythriol tetraacrylate (PETRA)] polymerizable groups.The copolymers were obtained by radical bulk polymerization with 2,2'-azobis(isobutyronitrile) (AIBN) as polymerization initiator.TMSPMA and MMA were also copolymerized by "in-situ" and simultaneous hydrolysis-condensation of the methoxy groups of TMSPMA during the free radical polymerization of MMA using AIBN in order to fully approach a sol-gel inorganic glass-organic polymer hybrid solid-state dye laser material.Structural and thermo-mechanical studies (thermogravimetry,differential scanning calorimetry,and infrared spectroscopy) revealed the highest thermo-mechanical stability for high-degree inter-crossing copolymerisation [COP(TMSPMA-PETA),COP(TMSPMA-PETRA)] and hydrolysis-polymerization [COPH(MMA-TMSPMA)].Concerning the optical spectroscopy characterisation,all studied PM597 doped copolymer samples exhibited high fluorescence quantum yields (60 % to 70 %),negligibly small excited-state absorption cross-sections (5% to 10 % of ground-state absorption at 527 nm),and high photo-stability (typically up to 3 million excitation cycles before degradation after some initial fading).The laser properties of the PM597 doped copolymers were evaluated by transversal pumping with 6 ns laser pulses of 5.5 mJ energy at 532 nm.Most of the studied samples surpassed 100 000 laser shots with no or only less than 50 % of laser output power reduction.     

What is Going on in a Critical Thermosyphon?

IntroductionWell- known optical phenomena in fluids in thethermodynamic critical state are the disappearanceof the meniscus between liquid and vapour phaseand the existence of a“critical opalescence”.　 This opalescence is observed as bluish inreflected…     

Hyperbranched Organometallic Polyynes :Optical and Thermal Properties and Their Transformation into Soft Ferromagnetic Ceramics

1Introduction Organometallic polymers have emerged as a group of interesting materials due to their useful catalytic,optical, electrical, sensing, and magnetic properties inaccessible by their pure organic parents. It is therefore highly desirable to utilize this class of high performance macromolecules for the preparation of micro- and nanosized patterns by photolithographic techniques and as precursors for advanced ceramics[1].     

X70管线钢焊接接头组织及其海水腐蚀规律

对X70管线钢现场实际焊接工艺下的焊接接头,采用显微镜、电化学方法及失重法等方法和手段对母材、焊缝、热影响区进行了显微组织分析和在海水中的极化曲线、腐蚀速率的测试,研究焊接接头在模拟海水环境中的腐蚀性能。研究表明,X70管线钢焊接接头各区域组织不均匀,实验室模拟海水环境下的电化学行为、腐蚀速率存在明显差异;在海水腐蚀过程中腐蚀电位和腐蚀速率会发生变化,热影响区（HAZ）与母材及焊缝形成电偶腐蚀,接头腐蚀以点蚀为主。     

疏水缔合聚合物凝胶调剖剂在陆9K1h油藏的应用

针对油水层复杂、渗透率高、含水上升快的陆9K₁h油藏,在室内通过筛选增粘能力和抗剪切能力较强的疏水缔合聚合物作为调剖用凝胶主剂,采用酚醛类作为交联剂,研制的凝胶体系（AP-BC）表观黏度可达11×10⁴mPa·s,并具有较好的稳定性;经多孔介质剪切后凝胶成胶时间延长50%,胶体强度降低小于10%,稳定性更好,老化5个月未见脱水现象;在相同渗透性的油、水饱和的填砂管实验中,AP-BC凝胶更易封堵水层。由于陆9K₁h油藏具有底水、薄层的特点,因此采用了“垫+调+堵”多段塞深部封堵的工艺,通过逐渐提高弱凝胶的强度,促使高强度堵剂得到合理的放置,实现对高渗透大孔道的封堵作用,提高注水开发的波及效果。现场试验表明,7个井组中,对应油井在调剖后第2个月到第6个月期间见到了明显增油效果。     

气体泡压法在测试储集层孔隙结构中的应用

测试储集层岩石孔隙结构的常规方法是压汞和铸体的薄片图像分析法,气体泡压法利用流体在孔喉内流动的物理规律来测定孔隙结构特征,能较真实地反映流体通过喉道的实际情况。对比分析气体泡压法与压汞法测试结果,后者测试出的主流孔喉直径是前者的2~4倍,前者测试储集层中参与渗流的有效喉道的分布特征,且更切合工程实际需要;对岩样酸化前后以及含水敏性矿物的岩样在水化前后的有效喉道分布进行了对比分析,能够明显地表征出酸化及水化前后有效喉道分布特征的变化情况,测试结果的对比性强、价值高。气体泡压法为测试储集层孔隙结构提供一种新方法和新途径。     

考虑拟流度比的蒸汽驱前缘预测模型研究

Van Lookeren研究了拟流度比为0时的蒸汽驱前缘预测模型,提出形状因子取得最大值时的注汽参数为最优参数。而在实际油藏中,由于地层中原油黏度较大,或注汽速率较小,拟流度比往往较大,此时利用最大形状因子优化注汽参数受到限制。针对该情形,应用数学方法研究了拟流度比不为0时的蒸汽驱前缘预测模型。绘制了形状因子、拟流度比、注汽速率与前缘形状关系图版,发现增大注汽速率,可增大形状因子,从而减小拟流度比,减轻蒸汽超覆程度,提高前缘驱的波及效率。由于注汽速率受注汽压力限制,研究了注汽速率与注汽压力的协调关系,利用该关系和研究的前缘模型,对前人的注汽参数优化方法进行了改进。     

地层厚度系数法研究查干凹陷构造演化

根据沉积补偿原理,提出地层厚度系数研究构造运动的方法,并分析了其研究步骤及适用范围。依据查干凹陷下白垩统关键层位地层厚度发育特征,利用沉积厚度法研究其构造活动,指出了影响整个凹陷沉积过程中的关键时期。结果表明：查干凹陷从巴二期,经苏一至苏二下亚段沉积时期,沉积中心发生改变,显示出明显呈北西—南东向的“跷跷板”构造运动。在这一认识基础之上进一步研究了查干凹陷构造演化,认为：白垩纪以来经历了裂陷阶段、断拗转换阶段、拗陷阶段和反转阶段,为查干凹陷今后的研究奠定了基础。     

固井前置冲洗液的研究发展

冲洗液的主要作用是冲刷井壁和套管壁的虚泥饼、油浆和油膜,稀释钻井液使之保持良好的流动性能。从而提高顶替效率并改善界面亲水能力,提高第一、二界面胶结强度,提高固井质量的。所以我们要在使用前要进行合理的设计,要全面了解其种类、性能标准、体系常用组分及作用原理、设计要求以及性能评价手段、方法、标准等,这样才能很好的利用和综合发挥冲洗液的作用。