Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors

The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.     

An Adaptive Identification and Control Scheme Using Radial Basis Function Networks

1.INTaODUCTIONThemultilayerfeedforwardneuralnetworks(MFNN)hasbeenwidelyappliedinmanyfieldssuchaspatternrecognition,nonlinearoptimization,systemidentificationandcontrol.Thesimpleback-propagation(BP)learningalgorithmisusuallyadoptedtoupdateitsweights.TheBPalgorithm,however,suffersdrawbacksofslowconvergenceandunpredictablesolutionsduringlearning.Althoughmailyapproachessuchasvariablestepsize,conjugategradient,pseudo-Newtonmethods[4]andothermethods[3,10],havebeendevelopedtoovercometheproble…     

融合LDA主题模型和支持向量机的商品个性化推荐方法

针对网络商品评论数据不能有效引导买方做出合理选择的问题,提出一种融合LDA主题模型和支持向量机的商品个性化推荐方法。首先爬取不同类型商品的用户评论数据并对其进行预处理;其次建立基于LDA的主题模型并对其特点进行量化;最后利用支持向量机实现商品个性化推荐。以智能手机商品为例进行实验分析,结果表明,所提方法能获得98%以上的分类精度。     

GROUP-BUYING ONLINE AUCTION AND OPTIMAL INVENTORY POLICY IN UNCERTAIN MARKET

In this paper we consider a group-buying online auction (GBA) model for a monopolistic manufacturer selling novel products in the uncertain market. Firstly, we introduce the bidder's dominant strategy, after which we optimize the GBA price curve and the production volume together. Finally, we compare the GBA with the traditional posted pricing mechanism and find that the GBA is highly probable to be advantageous over the posted pricing mechanism in some appropriate market environments.     

STABILITY CRITERIA FOR A CLASS OF UNCERTAINSYSTEMS WITH TIME—DELAY

Some stability criteria are obtained for a class of uncertain systems with time-delay usingLyapunov functional and analytic techniques. It is easy to check the criteria by making use of theboundedness of the uncertainties.     

A Sensitivity-Based Heuristic Search for Constrained Optimization in Complex Systems

1.INTRODUCTIONThealgorithmforconstrainedoptimizationincomplexsystemscanbedividedintotwoclasses:exactandheuristicmethods.Theexactmethods,whicharepartlysummarizedbyTitanetal.[1],havecomputationalrequiremeatsthatgrowexponentiajlywiththesizeoftheproblem.AlthoughheuristicmethodshavemodestcomputationalrequirementsandareeasytoAnplemellt,theyaregenerallyforredundancyallocation[2-4].2.S~EMENTOFProBLEM2.1NotationN:nUmberofcomponents;M:numberofconstraints;Rs:systemreliability;Rj:thereliabili…     

Analysis of Reliability for 3-State DeviceNetwork with Link-Capacities

1.INTRODUCTION2-statesystemreliabilityoftenassumesthatthesystemisrepresentedbyaprobabilisticgraphG=(V,E),withasetV~{yi,v2,'',}ofvenicesandasetE~{el,e2,'',}ofedges(orlinks,branches)containedinit.Thesystemisfunctioningifthereexistsapathfromtheinputnodetotheoutputnode.Thusthereliabilityisconsideredwithamatterofconnectivityonlyandthereliabilityanalysishasbeenprimarilyconcernedwiththeenumerationofpathesorcutsinthereferences[1-4].Butinmanyphysicalsystemsuchaspowertransmissionsystems,oilorwat…     

Research on Insurance Pricing

1.INTRODUCTIONInsurancepricingisaneternalthemeinthestudyofinsurance.Whenwedesignainsuranceproduct,wemusttogiveapricefortheproductinordertoselltheproductininsurancemarkets.Whatiscalledinsurancepricingisactuallytomakeinsurancepremiumofinsuranceproduct.Reasonablepricingofinsuranceproductisofutmostimportancefortheexistenceanddevelopmentofinsurancecompany.Ifpremiumismadetoohigh-priced,althoughinsurancecompanycanobtainhighprofitofunderweightingadcanheightencapacityofinsurancecompanyinpaymentofd…