修饰玻碳电极对多巴胺和尿酸的电化学检测（英文）

在单壁碳纳米管(SWCNT)表面修饰[Cu(sal-β-Ala)(3,5-DMP_2)]玻碳电极(GCE),该修饰电极不仅对多巴胺(DA)和尿酸(UA)具有很好的电化学催化效果,而且对它们有很强的检测能力.[Cu(sal-β-Ala)(3,5-DMP_2)]修饰电极对DA的检测线性范围为10~210 mmol/L,检测极限为7.29μmol/L;而对UA的检测线性范围为从1~86mmol/L,检测极限为1.5μmol/L.同时,利用微分脉冲伏安法(DPV)来测定DA和UA,相比之下,[Cu(sal-β-Ala)(3,5-DMP_2)]与单壁碳纳米管及修饰玻碳电极结合具有良好的灵敏度和分辨率.     

Evaluating the reliability of microsatellite genotyping from low-quality DNA templates with a polynomial distribution model

Molecular studies using trace DNA, such as from museum specimens, ancient or forensic samples and samples obtained noninvasively, often have a common problem of low quality of DNA templates. Amplification errors, such as allelic dropout and false allele, may arise during polymerase chain reaction (PCR) using such samples. A mathematical model which treats homozygotes and heterozygotes discriminately has been developed to measure sample quality and compute the confidence level of using multipletube approaches. We use plucked hair samples collected from 26 individual Sichuan snub-nosed monkeys (Rhinopithecus roxel- lana) to test the model. In this case, a confidence level of 99% can be achieved by three positive PCRs. If the sample quality is very poor and requires many PCR replicates, an alternative multiplestep genotyping method is recommended. This model enables researchers to optimize experimental protocols through pilot studies and obtain reliable genetic information using noninvasive sampling method.     

Understanding atomic-scale phase separation of liquid Fe-Cu alloy

Using liquid Fe 60 Cu 40 alloy as a model, the structure of liquid Fe-Cu alloy systems is investigated in the temperature range 1200 2200 K, covering a large metastable undercooled regime, to understand the phase separation of liquid Fe-Cu alloys on the atomic scale. The total pair distribution functions (PDFs) indicate that liquid Fe 60 Cu 40 alloy is ordered in the short range and disordered in the long range. If the atom types are ignored, the total atom number densities and PDFs demonstrate that the atoms are distributed homogenously in the liquid alloy. However, the segregation of Fe and Cu atoms is very obvious with decreasing temperature. The partial PDFs and coordination numbers show that the Cu and Fe atoms are not apt to get together on the atomic scale at low temperatures; this will lead to large fluctuations and phase separation in liquid Fe-Cu alloy.     

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.     

热处理对Cu-Al-Mn形状记忆合金阻尼能力的影响

高阻尼材料在控制噪音弱化机械振动稳定材料结构等方面具有极高研究价值。Cu-Al-Mn形状记忆合金是一种重要的高阻尼材料。采用内耗技术系统地研究了Cu-11.33Al-5.71Mn(wt.%)形状记忆合金的基本阻尼行为,通过不同方式的热处理,改变材料中的缺陷状态,进一步研究材料阻尼行为的变化,以获得材料微观组织和阻尼特征之间的关系,为深入了解该合金的阻尼机制奠定基础。在室温～270℃的内耗温度谱中,98℃附近出现了一个典型相变内耗峰。随着保温时长的增加,阻尼先增加后逐渐下降。分析认为,时效时长增加,淬火空位浓度降低,空位对相界面移动的阻碍作用减弱,阻尼增加;时效20 min,空位浓度达到动态平衡,随后马氏体数量逐渐减少,相界面移动减少,阻尼降低。因此了解热处理与材料微观结构的变化关系对于优化材料组织与阻尼性能是具有价值的。     

Existence of Equilibrium of Multiperiod Plan-Market Economy with the Stock Market

1　IntroductionWilliamA.ByrdhasstudiedtheexistenceofequilibriuminasimplemodelwithdistinctiveChineseeconomy(seeByrd,1989).Industrialgoodsaresubjecttomultipleallocationmechanism,includingvariousadministrativechannels,termedplanningsystemandcom-modityma...     

Protein Residue Contact Prediction Based on Deep Learning and Massive Statistical Features from Multi-Sequence Alignment

Sequence-based protein tertiary structure prediction is of fundamental importance because the function of a protein ultimately depends on its 3 D structure.An accurate residue-residue contact map is one of the essential elements for current ab initio prediction protocols of 3 D structure prediction.Recently,with the combination of deep learning and direct coupling techniques,the performance of residue contact prediction has achieved significant progress.However,a considerable number of current D...     

Radon-Nikodym theorem in signed Loeb space

This paper gives the Radon-Nikodym theorem in signed Loeb space under 1-saturated nonstandard model. First,the nonstandard characterization of absolute continuity is discussed,on which Radon-Nikodym theorem in signed Loeb space is obtained. Then,some facts about a finite signed Loeb measure and its variation are shown.     

Amplitudes, rates, periodicities and causes of temperature variations in the past 2485 years and future trends over the central-eastern Tibetan Plateau

Amplitudes, rates, periodicities, causes and future trends of temperature variations based on tree rings for the past 2485 years on the central-eastern Tibetan Plateau were analyzed. The results showed that extreme climatic events on the Plateau, such as the Medieval Warm Period, Little Ice Age and 20th Century Warming appeared synchronously with those in other places worldwide. The largest amplitude and rate of temperature change occurred during the Eastern Jin Event (343-425 AD), and not in the late 20th century. There were significant cycles of 1324 a, 800 a, 199 a, 110 a and 2-3 a in the 2485-year temperature series. The 1324 a, 800 a, 199 a and 110 a cycles are associated with solar activity, which greatly affects the Earth surface temperature. The long-term trends (>1000 a) of temperature were controlled by the millennium-scale cycle, and amplitudes were dominated by multi-century cycles. Moreover, cold intervals corresponded to sunspot minimums. The prediction indicated that the temperature will decrease in the future until to 2068 AD and then increase again.