Simulating FAS-induced apoptosis by using P systems

In contrast to differential equations, P systems are an unconventional model of computation which takes into consideration the discrete character of the quantity of components and the inherent randomness that exists in biological phenomena. The key feature of P systems is their compartmentalised structure which represents the heterogeneity of the structural organisation of the cells, and where one can take into account the role played by membranes in the functioning of the system, for example signalling at the cell surface, selective uptake of substances from the media, diffusion across different compartments, etc. We show here that P systems can be a reliable tool for Systems Biology and could even outperform in some cases the current simulation techniques based on differential equations. We will also use a strategy based on the well known Gillespie algorithm but running on more than one compartment called Multi-compartmental Gillespie Algorithm.     

Genetic background of phenotypic variation

A noteworthy feature of the living world is its bewildering variability. A key issue in several biological disciplines is the achievement of an understanding of the hereditary basis of this variability. Two opposing, but not necessarily irreconcilable conceptions attempt to explain the underlying mechanism. The gene function paradigm postulates that phenotypic variance is generated by the polymorphism in the coding sequences of genes. However, comparisons of a great number of homologous gene and protein sequences have revealed that they predominantly remained functionally conserved even across distantly related phylogenic taxa. Alternatively, the gene regulation paradigm assumes that differences in the cis-regulatory region of genes do account for phenotype variation within species. An extension of this latter concept is that phenotypic variability is generated by the polymorphism in the overall gene expression profiles of gene networks. In other words, the activity of a particular gene is a system property determined both by the cis-regulatory sequences of the given genes and by the other genes of a gene network, whose expressions vary among individuals, too. Novel proponents of gene function paradigm claim that functional genetic variance within the coding sequences of regulatory genes is critical for the generation of morphological polymorphism. Note, however, that these developmental genes play direct regulatory roles in the control of gene expression.     

┱?例杨金彪;福建省南平市第

鸨?114尼美舒利致肝功能损伤1例陈瑶;李岚;厦门市妇幼保健院药剂科,上海儿童医学中心药剂科 厦门361000,上海200000尼美舒利;;肝功能损害0海峡药学Strait Pharmaceutical Journal118-119R725.9E06938E;E069_38陈瑶;114-115门诊药房实行专科药师制度的必要性陈成辉;何丽芳;     

Self-Dual Hadamard Bent Sequences

A new notion of bent sequence related to Hadamard matrices was introduced recently,motivated by a security application(Solé, et al., 2021). The authors study the self-dual class in length at most 196. The authors use three competing methods of generation: Exhaustion, Linear Algebra and Gr?bner bases. Regular Hadamard matrices and Bush-type Hadamard matrices provide many examples. The authors conjecture that if v is an even perfect square, a self-dual bent sequence of length v always exists. The ...     

RSS拓补结构机座的动态优化

以燃气轮机透平端RSS(旋转对称支承板)机座为研究背景,通过用D’Alembert原理建立了RSS机座的拓补优化域和等价边界条件,从而实现了用均匀化方法的RSS机座拓扑结构优化,得到了旋转对称的弧形支承板拓扑结构的机座.然后,结合原来RSS机座的机构特征在ANSYS workbench中建立了RSS拓补结构光滑有限元模型,并进行了工作条件下的模态分析,以前三阶模态振型中轴承座的振型作为当量静载荷加载到原模型对比计算,验证边界条件的正确性.以RSS机座弧形支承板的四个关键尺寸为设计变量,以机座的变形量和应力为目标函数,进行了随频率变化的动态优化设计.通过优化改变了RSS拓补结构的动态特性,使固有频率远离了工作频率.     

Microstructural evaluation and nanohardness of an AlCoCuCrFeNiTi high-entropy alloy

An AlCoCuCrFeNiTi high-entropy alloy(HEA) was prepared by mechanical alloying and sintering to study the effect of Ti addition to the widely studied AlCoCuCrFeNi system. The structural and microstructural characteristics were investigated by X-ray diffraction(XRD), scanning electron microscopy(SEM), and transmission electron microscopy(TEM). The formation of four micrometric phases was detected: a Cu-rich phase with a face-centered cubic(fcc) structure, a body-centered cubic(bcc) solid solution with Cu-rich plate-like precipitates(fcc), an ordered bcc phase, and a tetragonal structure. The XRD patterns corroborate the presence of a mixture of bcc-, fcc-, and tetragonal-structured phases. The Vickers hardness of the alloy under study was more than twice that of the AlCoCuCrFeNi alloy. Nanoindentation tests were performed to evaluate the mechanical response of the individual phases to elucidate the relationship between chemical composition, crystal structure, and mechanical performance of the multiphase microstructure of the AlCoCuCrFeNiTi HEA.     

高层建筑形状及布局对城市街区 行人风环境影响研究

基于风洞试验和计算流体动力学方法(Computational Fluids Dynamics,CFD)研究高层建筑形状及布局对城市街区行人风环境的影响.采用最大风速比和归一化加速面积比,定量研究五种高层建筑形状及四类建筑布局对城市街区行人风环境的影响,确定全风向下的最优建筑形状以及布局,结合CFD数值模拟获得的全域流场信息,揭示建筑形状和布局对于城市街区行人风环境的影响机理.结果表明:在保持建筑高度和街区容积率一致的情况下,高层建筑群周边最大风速比不会随着建筑形状和建筑布局的改变而发生明显变化.但建筑形状和建筑布局会改变建筑群周边高风速区域的面积大小,全风向下的最优建筑形状和布局分别是Y字形和错列式布局,而最不利形状和布局分别是H字形和围合式布局.不同布局下的方形、H字形及X字形高层建筑群的最不利风向均位于斜风向,而十字形及Y字形则为正风向.高层建筑群在行人高度处的风加速现象主要是由狭管效应和角部分离效应造成的.     

基于动态燃料成本双层优化的 燃煤发电企业管控模型

为使燃煤发电企业降低燃料成本,实现燃料科学管控,提出一种综合考虑发电可靠性和生产经济性的燃料成本双层优化模型,上层为电煤采购库存混合整数规划模型,下层为混煤掺烧非线性优化模型,双层模型交替迭代协调优化,实现燃料管控动态决策.针对优化模型高维多约束情况,提出一种混沌映射初始化和高斯变异结合的改进灰狼优化算法.以某燃煤电厂模拟运营进行算例验证分析,结果表明,所提模型可以降低燃煤电厂7.80％的燃煤成本,证明了所提模型与求解算法的有效性和可行性.     

FOXM1688-748结构域相互作用蛋白的鉴定

为了鉴定转录因子FOXM1转录激活结构域(C-端第688位到748位氨基酸序列)的互作蛋白,以FOXM1的cDNA为模板,采用聚合酶链式反应(Polymerase Chain Reaction,PCR)方法扩增获得其转录激活结构域序列,克隆进入原核表达载体pGEX-4T2;利用大肠杆菌原核表达获得融合谷胱甘肽S-转移酶(Glutathione S-Transferase,GST)标签的重组蛋白GST-FOXM1688-748;通过GST-pulldown结合质谱方法鉴定FOXM1688-748的互作蛋白,成功构建了原核表达质粒pGEX-4T2-FOXM1688-748,获得了原核表达的重组蛋白GST-FOXM1688-748.将质谱鉴定获得的互作蛋白进行分析和归类,预示一些互作蛋白可以参与激活FOXM1的转录活性,如RPN2、MISP、MCM7蛋白,一些互作蛋白可以参与调控FOXM1蛋白的稳定性,如USP9Y、CUL4A、HSPB1、BAG2蛋白.FOXM1蛋白的转录激活结构域与许多不同功能的蛋白发生相互作用,暗示该结构域具有重要的分子生物学作用,期望为以FOXM1为靶点的临床药物研发提供实验依据.     

功能梯度仿生头盔防护性能与头部损伤分析

为了提高摩托车头盔防护性能降低头部损伤风险,本文引入功能梯度仿生泡沫结构替代传统头盔的均匀密度泡沫衬垫.通过头盔耦合生物力学头部有限元模型,获取撞击过程中头部质心加速度、生物力学响应和头盔结构响应,综合分析不同密度梯度方案对头盔防护能力的影响.结果表明,功能梯度泡沫结构在中高速冲击下有更明显的优势.相比传统头盔吸能缓冲层的均匀泡沫密度方案和新型头盔的正/负密度梯度方案,最大密度为80 kg/m3的负密度梯度泡沫设计方案可以更有效改善头盔结构碰撞响应并降低碰撞过程中头部损伤,且随着密度差的增大,负密度梯度头盔的防护性能得到了进一步提高.