CSE/H2S通路缺失影响小鼠肝脏胆固醇和脂肪酸代谢（英文）

肝脂质代谢异常导致过度肝脂肪沉积和脂肪变性是脂肪肝发展的关键环节.胱硫脒-伽马-裂解酶(CSE)是在肝脏中催化硫化氢(H2S)生成的酶之一.本研究的目的是研究CSE/H2S在调控肝脏胆固醇和脂肪酸代谢中的作用.用高脂饮食(HFD)喂食野生型(WT)和CSE敲除(KO)小鼠后,对小鼠肝形态学和生物化学变化进行了分析.与WT小鼠不同,HFD喂食显著增加CSE-KO小鼠的血浆和肝脏胆固醇水平以及肝和胆囊的大小.这些CSE-KO小鼠呈现典型的脂肪肝组织学和生物化学变化以及肝功能损害.血浆和肝脏甘油三酯水平也比HFD喂养WT小鼠显著降低.核受体转录因子LXRα以及它的靶基因,CYP7A1,在对照组和HFD组CSE-KO小鼠肝脏中的表达都低于相应WT小鼠的水平.这些异常阻碍胆固醇分解成胆汁并导致胆固醇蓄积在肝脏和胆囊.由于CSE/H2S通路缺失造成对HFD诱导的脂肪肝的高易感性,肝脏CSE/H2S通路可能是治疗脂肪肝损伤的一个新的靶向.     

Magnetoelectric Bi_(3.15)Nd_(0.85)Ti_3O_(12)–NiFe_2O_4 bilayer films derived by a SOL–GEL method

Magnetoelectric Bi3.15Nd0.85Ti3O12–NiFe2O4(BNT–NFO) bilayer films were deposited on Pt/Ti/SiO2/Si(100) substrates by a simple SOL–GEL method and spin-coating process with different growth sequences of BNT and NFO yielding the following layered structures: BNT/NFO/substrate(BNS) and NFO/BNT/substrate(NBS). Such heterostructures present simultaneously strong ferroelectric and ferromagnetic responses,as well as magnetoelectric effects at room temperature. BNS thinfilms showed larger ME voltage coefficient than NBS films, revealing that the layer sequences have a significant in fluence on the magnetoelectric coupling behavior of these bilayer structures, which may be caused by a interfacial effect.     

Non-Uniform APSK Optimization for BICM Systems

Traditional Amplitude Phase Shift Keying(APSK) consists of rings with points uniformly spaced. By giving up this uniform-spacing feature, we propose an APSK optimization method based on the uniform APSK with Gray labeling(Gray-APSK). The aim of the optimization is to maximize the Generalized Mutual Information(GMI)of Bit-Interleaved Coded Modulation(BICM) for the targeted code rate and channel. We show that our optimized non-uniform APSK could offer further performance gain compared with the conventional uniform Gray-APSK and considerably outperforms the traditional quadrature amplitude modulation at the targeted SNR and channel.     

搞好农田水利建设 促进农民增产增收

微山县以农业为主，农业用水占85％，由于大部分是土渠，灌溉水的利用率较低，节水潜力巨大。要大力推广渠道防渗技术，降低灌溉成本，节水，节地，省电，确保增产增收。只有这样农民才能真正得到实惠，为全面建设小康社会奠定竖实的基础。     

第（3）类ψ－压缩映对的一个新的公共不动点定理

证明了第（3）类ψ－压缩映射对的一个新的公共不点定理，推广文献[1-3]中的相关结果。     

等电聚焦电泳法分离鉴定生漆中同工酶

从中国湖北建始和利川毛坝生漆中提取粗漆酶，应用等电聚焦电泳（IEF）技术分离鉴定同工酶。实验结果表明，除了含有能催化多胺或多酚的氧化酶（漆酶）外，还有酯酶和过氧化酶。氧化酶同工酶建始漆共有18条带、毛坝漆有15条带；酯酶同工酶建始漆有20条带、毛坝漆有18条带；过氧化酶建始漆有18条带、毛坝漆只有6条带。并测定了各酶带的等电点。     

THE SHEAR-THINNING PHENOMENON OF BAGASSE KRAFT BLACK LIQUOR FLUID

INTRODUCTIONKraft black liquor composition is very complicated. Generally, it is a complex and multiphase fluid, which consists of organic and inorganic components. The total solids content in black liquors has a great effect on its fluidity and deformation. To the wood black liquor, there have already been detailed researches on their flow properties and many theoretic or practical results have been concluded in the literatures [1-8]. But to non-wood black liquor, the previous researches…     

Blind source separation of ship-radiated noise based on generalized Gaussian model

1 .INTRODUCTIONBlind source separation (BSS) in signal processinghas received considerable attention from many re-searchers .It is a fundamental problem in signalprocessing with a large number of extremely di-verse applications such as multi-user communica-tions ,speech signal processing, array processingand medical signal processing including ECG,MEGand EEG. The general goal of blind sourceseparation (BSS) is to separate the statistically in-dependent , unknown source signals from t…     

一种抗裁剪和旋转的盲水印嵌入新方法

在满足提取水印完整性的前提下，提出了一种可抗相应角度裁剪和旋转攻击的水印嵌入新方法，它以掩饰图像中心为对称点，将图像按一定角度要求划分成均等的若干块，其中每一块均可通过给定角度倍数的旋转与参考块重合。通过对水印的裁剪和旋转攻击方法的分析，给出将对称思想与多次嵌入方法相结合的解决方案，分析并证明了它对如上的角度裁剪和旋转攻击具有鲁棒性。具体介绍了实现不印时的嵌入策略，并讨论了嵌入量和鲁棒性之间的关系。本文提出的新方法，其特点是不依赖于工作域的选择，同时也与具体水印嵌入算法无关。试验结果表明它对于抵抗相应攻击具有有效性。     

A Novel Immune System Model and Its Application to Network Intrusion Detection

Based on analyzing the techniques and architecture of existing network Intrusion Detection System (IDS), and probing into the fundament of Immune System (IS), a novel immune model is presented and applied to network IDS, which is helpful to design an effective IDS. Besides, this paper suggests a scheme to represent the self profile of network. And an automated self profile extraction algorithm is provided to extract self profile from packets. The experimental results prove validity of the scheme and algorithm, which is the foundation of the immune model.