基于ANN的报高率确定规则产生模型

根据人工神经网络和投标报价报高率确定决策的特征 ,将人工神经网络应用于工程项目的报高率确定决策领域 ,利用人工神经网络得出确定报高率的规则 ,建立更加接近于人类思维模式的投标报价报高率确定决策模型 ,并在此基础上建立报高率确定决策事例库 ,以辅助投标商更好地进行投标报价决策     

不确定环境下基于实物期权的IT项目风险与价值综合评估方法

将模糊风险评估与实物期权方法进行综合,提出了基于模糊理论的实物期权风险评估方法,从风险来源出发考虑对于IT项目价值的影响,用模糊理论表达和推理期望收益的不确定性,对波动率参数进行估计,以解决期权模型假设难以满足,应用起来比较复杂的问题.并通过某核电站供应商管理信息系统的案例对该评估方法进行了说明.     

Investigation of coupled cobalt–silver nanoparticle system by plan view TEM

We present a transmission electron microscopy (TEM) investigation of a coupled cobalt and silver nanoparticle system. A plan view in situ lift-out method for preparing samples for TEM using the focused ion beam (FIB) microscope was used. This technique is used to prepare high quality TEM samples with site specificity in a short time and with a high success rate. We demonstrate the ability of the plan view sample preparation technique to provide information about an ordered system of nanoparticles which could not be observed using standard FIB cross sectioning of the sample. High resolution TEM and energy dispersive X-ray spectroscopy mapping of both cross sectional and plan view samples are presented, clearly showing the significant benefit of plan view TEM analysis for certain samples     

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Approximately 10% of cases are familial (FALS), typically with a dominant inheritance mode. Despite numerous advances in recent years, nearly 50% of FALS cases have unknown genetic aetiology. Here we show that mutations within the profilin 1 (PFN1) gene can cause FALS. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Exome sequencing of two large ALS families showed different mutations within the PFN1 gene. Further sequence analysis identified 4 mutations in 7 out of 274 FALS cases. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. PFN1 mutants also display decreased bound actin levels and can inhibit axon outgrowth. Furthermore, primary motor neurons expressing mutant PFN1 display smaller growth cones with a reduced F/G-actin ratio. These observations further document that cytoskeletal pathway alterations contribute to ALS pathogenesis.     

实体店及其网上商店产品的动态定价及订货策略

以实体店和网上商店两种销售模式通常共用一个订货渠道来满足顾客的不同需求为背景,分析了拥有实体店和网上商店公司的最优订货策略、最优的价格调整次数问题,并推导出了不同时期的最优定价策略.然后,利用数值算例分析了价格调整次数未知与已知两种情况下的最优决策.最后,指出了未来可能的几个研究方向.     

一中生代哺乳动物齿列的新奇特征

哺乳动物的颊齿分前臼齿和臼齿.两组牙齿形态有差别,但各组内牙齿形态一般由前向后渐变.本文报道新发现的一中生代对齿兽类哺乳动物,其前臼齿与臼齿在形态与功能上有过渡,但臼齿本身从前向后分3个区段,形态不连续.这一齿列特征在现生哺乳动物和其它化石类群中从无记录.这一现象     

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

Arterial tortuosity syndrome (ATS) is an autosomal recessive disorder characterized by tortuosity, elongation, stenosis and aneurysm formation in the major arteries owing to disruption of elastic fibers in the medial layer of the arterial wall. Previously, we used homozygosity mapping to map a candidate locus in a 4.1-Mb region on chromosome 20q13.1 (ref. 2). Here, we narrowed the candidate region to 1.2 Mb containing seven genes. Mutations in one of these genes, SLC2A10, encoding the facilitative glucose transporter GLUT10, were identified in six ATS families. GLUT10 deficiency is associated with upregulation of the TGFbeta pathway in the arterial wall, a finding also observed in Loeys-Dietz syndrome, in which aortic aneurysms associate with arterial tortuosity. The identification of a glucose transporter gene responsible for altered arterial morphogenesis is notable in light of the previously suggested link between GLUT10 and type 2 diabetes. Our data could provide new insight on the mechanisms causing microangiopathic changes associated with diabetes and suggest that therapeutic compounds intervening with TGFbeta signaling represent a new treatment strategy.     

基于随机游走成交价格的连续竞价市场交易策略

随机游走市场中的证券价格变动是不可预测的,如何在这样的市场中设计交易策略是一个难点问题。本文在MATLAB平台上构建了一个满足随机游走的人工连续竞价市场,提出了一个"盯准最优价格"(Eye-On-Best,简称EOB)交易策略。通过不同类型供需曲线下的位置替换重复仿真实验,比较了EOB策略和"约束型零信息"(简称ZI-C)策略的收益差异。研究表明,EOB策略获得的收益总体上优于ZI-C策略,且其收益受市场力的影响。研究结论为交易者在满足随机游走的证券市场如何进行报价提供决策依据。     

软件工程技术及其对数据库设计的作用

本文对软件生存周期各阶段的软件工程技术进行分析,并结合数据库设计实践,阐明软件工程技术对数据库设计的作用.