Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Inflammatory substances released by mast cells induce and maintain the allergic response. Mast cell differentiation and activation are regulated, respectively, by stem cell factor (SCF; also known as Kit ligand) and by allergen in complex with allergen-specific immunoglobulin E (IgE). Activated SCF receptors and high-affinity receptors for IgE (FcvarepsilonRI) engage phosphoinositide 3-kinases (PI(3)Ks) to generate intracellular lipid second messenger signals. Here, we report that genetic or pharmacological inactivation of the p110delta isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen-IgE-induced degranulation and cytokine release. Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies.     

动物保护科学

保护观赏动物以及供研究和农业用的动物健康,也有益于人类。     

敏捷后勤系统的分布式仿真体系结构

针对敏捷后勤分布式仿真系统的构造需求,分析了仿真体系结构及系统描述方法的研究现状。应用主体信念-目标-意图(belief-desire-intention,BDI)的Petri网建模方法建立了描述敏捷后勤系统智能和分布特性的Petri网模型。在此基础上,提出了基于高层体系结构(high level architecture,HLA)的敏捷后勤系统分布式仿真体系结构,给出了该类系统的仿真策略。该仿真体系结构将集中式仿真和分布式仿真相结合,较好地反映了敏捷后勤系统的智能性、层次性、分布性、自治性、交互性、动态性等特性。