Molecular structure and biological function of proliferating cell nuclear antigen

Proliferating cell nuclear antigen (PCNA) is the core component of replication complex in eukaryote. As a processive factor of DNA polymerase delta, PCNA coordinates the replication process by interacting with various replication proteins. PCNA appears to play an essential role in many cell events, such as DNA damage repair, cell cycle regulation, and apoptosis, through the coordination or organization of different partners. PCNA is an essential factor in cell proliferation, and has clinical significance in tumor research. In this article we review the functional structure of PCNA, which acts as a function switch in different cell events.     

通气状况与氮素形态对水稻和旱稻生长的影响

采用营养液培养法研究通气状况与氮素形态对水、旱稻生长和养分吸收的影响。结果表明，通气与不通气相比，通气明显的增加了植物地上部和地下部的生物量；同时验证了水稻喜NH4^ 和旱稻喜NO3^-的吸收特性。叶面积测定与地上部生物量的趋势完全一致，表明这种生物量的增加与光合作用增强、光合面积增大有关。植物地上部全N、P、K含量测定显示，通气状况与氮素形态对水、旱稻生物量的影响与N、P、K营养元素的吸收没有直接关系。     

胰岛素原转化酶基因克隆及序列测定

目的研究胰岛素抵抗和胰岛素缺乏与Ⅱ型糖尿病发病机制的关系.方法Ⅱ型糖尿病普遍存在胰岛素、胰岛素原障碍,胰岛β细胞分泌出胰岛素原经胰岛素原转化酶(Prohormone convertase,PC2)去除部分肽段后形成胰岛素.结果与结论若PC降解功能异常可导致胰岛素原及其代谢产物不适当分泌引起胰岛素缺乏,研究该基因分布和表达的变化,对探讨糖尿病胰岛素抵抗的发病机制奠定基础.     

应对气候变化与军备控制的关联研究

气候变化与军备竞赛是当前人类面临的共同挑战.这两个挑战看上去是两个不同的议题,但是这二者之间却有着内在的联系.应对气候变化和推进军备控制都需要秉承人类命运共同体建设的基本哲学,在研究层面,这两个学科也存在直接的关联.本文以三个问题为例,介绍应对气候变化与军备控制这两个全球治理关键领域之间的关联研究.     

基于历史文化的GIS思政案例库建设

推进课程思政建设是国家重大战略决策.为丰富课程思政教学内容,提高地理信息科学专业人才培养质量,论文在响应党中央传承中华优秀传统文化的号召的同时,深入挖掘了GIS专业课程中所蕴含的历史文化思政资源,探索了GIS历史文化思政课程案例库的建设.以期通过实践教学把学生培养成既有过硬的专业知识,又具浓厚的家国情怀的爱国、敬业、坚...     

多目标有约束关系模糊网络图决策模型及其应用

根据多目标模糊决策理论，本文首先提出接近度概念，其次计算模糊关系矩阵并将其转化为接近度网络图。在此基础上，建立了基于网络最大流寻优的多目标有约束关系的模糊网络图决策模型。最后，应用该模型对某矿井工业广场的工程设计位置问题进行了多目标决策，效果很好。     

稀土-过渡族—Y-Hf、Y-Zr二元相图的计算

本文采用L.Kaufman的计算方法,用规则溶体模型对稀土元素钇(Y)与难溶过渡族元素锆(Zr)、铪(Hf)的二元系:钇—锆,钇—铪进行了相平衡计算。并比较了此二系的计算相图和实测相图,二者符合良好。     

Improving the solidification structure of commercially pure aluminium with electropulse acting on liquid metal

The effect of electropulse on the solidification structure of commercially pure aluminium was studied. The orthogonal array L9 was used to determine the effect of three process parameters of electropulse modification (EPM), which were pulse current intensity, pulse frequency, and treating time. For each factor, three levels were chosen to cover the experimental region. According to the experimental results, the solidification structure of commercially pure aluminium was modified from large grains with columnar crystals to finer grains with equiaxed crystals, by allowing the electropulse to act on liquid aluminium. However, the solidification structures could be refined differently at different EPM parameters. Certain EPM parameters should be selected to get the optimum solidification structure. Among the three parameters, pulse frequency was the most important factor influencing the solidification structure, the secondary factor was current intensity, and treating time was the third one. The optimum parameters were the pulse frequency of 5 Hz, the current intensity of 68 A, and the treating time of 10 s.     

高层建筑结构选型影响因素分析

现今,越来越多的高层建筑建筑伫立于城市之中,要想在建筑行业得到利益与名义的双丰收,光靠地皮的价位是远远不够的,更重要的是建筑结构选型的标新立异、材料施工的安全保障和后期服务的全面到位。下面,就高层建筑结构选型这一问题进行具体探究。     

基于Hadoop企业私有云存储平台的构建

针对企业级用户面临文件和数据量的指数级增长,现有的文件存储设施不能适应业务增长问题,提出基于Hadoop构建企业私有云存储平台,通过采用Linux集群技术、分布式文件系统和云计算框架,实现海量数据存储和高速数据处理业务。比较了私有云存储和传统存储模式,分析了私有云存储技术优势和可行性,提出企业私有云存储架构模型。分析结果表明:企业私有云存储平台适用于关键业务应用、在线事务处理,满足企业对海量数据存储、数据规模易扩展性的要求。